SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 1c9sA-2p5uA:
undetectable
1c9sK-2p5uA:
undetectable		 1c9sA-2p5uA:
12.68
1c9sK-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.44A 1c9sA-2p5uA:
undetectable
1c9sB-2p5uA:
undetectable		 1c9sA-2p5uA:
12.68
1c9sB-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.40A 1c9sC-2p5uA:
undetectable
1c9sD-2p5uA:
undetectable		 1c9sC-2p5uA:
12.68
1c9sD-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.43A 1c9sD-2p5uA:
undetectable
1c9sE-2p5uA:
undetectable		 1c9sD-2p5uA:
12.68
1c9sE-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 1c9sE-2p5uA:
undetectable
1c9sF-2p5uA:
undetectable		 1c9sE-2p5uA:
12.68
1c9sF-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 1c9sF-2p5uA:
undetectable
1c9sG-2p5uA:
undetectable		 1c9sF-2p5uA:
12.68
1c9sG-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.43A 1c9sG-2p5uA:
undetectable
1c9sH-2p5uA:
undetectable		 1c9sG-2p5uA:
12.68
1c9sH-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.44A 1c9sH-2p5uA:
undetectable
1c9sI-2p5uA:
undetectable		 1c9sH-2p5uA:
12.68
1c9sI-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 1c9sJ-2p5uA:
undetectable
1c9sK-2p5uA:
undetectable		 1c9sJ-2p5uA:
12.68
1c9sK-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.47A 1c9sL-2p5uA:
undetectable
1c9sM-2p5uA:
undetectable		 1c9sL-2p5uA:
12.68
1c9sM-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.48A 1c9sM-2p5uA:
undetectable
1c9sN-2p5uA:
undetectable		 1c9sM-2p5uA:
12.68
1c9sN-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.48A 1c9sO-2p5uA:
undetectable
1c9sP-2p5uA:
undetectable		 1c9sO-2p5uA:
12.68
1c9sP-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.46A 1c9sS-2p5uA:
undetectable
1c9sT-2p5uA:
undetectable		 1c9sS-2p5uA:
12.68
1c9sT-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		4 / 5 GLY A 299
LEU A 302
THR A 303
VAL A 294
 None
 1.08A 1ekjF-2p5uA:
undetectable
1ekjG-2p5uA:
2.2		 1ekjF-2p5uA:
19.62
1ekjG-2p5uA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 1gtfA-2p5uA:
undetectable
1gtfK-2p5uA:
undetectable		 1gtfA-2p5uA:
12.68
1gtfK-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.43A 1gtfA-2p5uA:
undetectable
1gtfB-2p5uA:
undetectable		 1gtfA-2p5uA:
12.68
1gtfB-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 1gtfB-2p5uA:
undetectable
1gtfC-2p5uA:
undetectable		 1gtfB-2p5uA:
12.68
1gtfC-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.44A 1gtfE-2p5uA:
undetectable
1gtfF-2p5uA:
undetectable		 1gtfE-2p5uA:
12.68
1gtfF-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 1gtfF-2p5uA:
undetectable
1gtfG-2p5uA:
undetectable		 1gtfF-2p5uA:
12.68
1gtfG-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 1gtfG-2p5uA:
undetectable
1gtfH-2p5uA:
undetectable		 1gtfG-2p5uA:
12.68
1gtfH-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.43A 1gtfI-2p5uA:
undetectable
1gtfJ-2p5uA:
undetectable		 1gtfI-2p5uA:
12.68
1gtfJ-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.48A 1gtfO-2p5uA:
undetectable
1gtfP-2p5uA:
undetectable		 1gtfO-2p5uA:
12.68
1gtfP-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 8 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.40A 1gtnA-2p5uA:
undetectable
1gtnB-2p5uA:
undetectable		 1gtnA-2p5uA:
12.68
1gtnB-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.49A 1gtnR-2p5uA:
undetectable
1gtnS-2p5uA:
undetectable		 1gtnR-2p5uA:
12.68
1gtnS-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		4 / 5 TYR A 217
TYR A 174
ILE A 300
GLY A 245
 None
 1.11A 1kifA-2p5uA:
4.8		 1kifA-2p5uA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		4 / 5 TYR A 217
TYR A 174
ILE A 300
GLY A 245
 None
 1.11A 1kifB-2p5uA:
4.8		 1kifB-2p5uA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		4 / 5 TYR A 217
TYR A 174
ILE A 300
GLY A 245
 None
 1.11A 1kifC-2p5uA:
3.2		 1kifC-2p5uA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		4 / 5 TYR A 217
TYR A 174
ILE A 300
GLY A 245
 None
 1.11A 1kifD-2p5uA:
4.9		 1kifD-2p5uA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		4 / 5 TYR A 217
TYR A 174
ILE A 300
GLY A 245
 None
 1.11A 1kifE-2p5uA:
4.9		 1kifE-2p5uA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		4 / 5 TYR A 217
TYR A 174
ILE A 300
GLY A 245
 None
 1.11A 1kifF-2p5uA:
3.1		 1kifF-2p5uA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		4 / 5 TYR A 217
TYR A 174
ILE A 300
GLY A 245
 None
 1.11A 1kifG-2p5uA:
5.2		 1kifG-2p5uA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		4 / 5 TYR A 217
TYR A 174
ILE A 300
GLY A 245
 None
 1.11A 1kifH-2p5uA:
4.9		 1kifH-2p5uA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 12 SER A 146
GLY A  96
ASP A  51
ASN A  32
LEU A  88
 None
None
NAD  A1118 (-3.0A)
NAD  A1118 (-3.1A)
None
 1.32A 1lhuA-2p5uA:
undetectable		 1lhuA-2p5uA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		4 / 7 ASN A  93
HIS A  72
PHE A 114
TYR A 143
 None
None
None
NAD  A1118 (-4.4A)
 1.28A 1tdnA-2p5uA:
2.8		 1tdnA-2p5uA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		6 / 11 GLY A   7
ALA A   9
ASP A  31
ASP A  51
ALA A  74
VAL A  92
 NAD  A1118 (-3.4A)
NAD  A1118 (-4.1A)
NAD  A1118 (-2.7A)
NAD  A1118 (-3.0A)
NAD  A1118 (-3.5A)
NAD  A1118 ( 4.7A)
 0.42A 1uayA-2p5uA:
17.8		 1uayA-2p5uA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		6 / 10 GLY A   7
ALA A   9
ASP A  31
ASP A  51
ALA A  74
VAL A  92
 NAD  A1118 (-3.4A)
NAD  A1118 (-4.1A)
NAD  A1118 (-2.7A)
NAD  A1118 (-3.0A)
NAD  A1118 (-3.5A)
NAD  A1118 ( 4.7A)
 0.45A 1uayB-2p5uA:
17.6		 1uayB-2p5uA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.44A 1utdA-2p5uA:
undetectable
1utdB-2p5uA:
undetectable		 1utdA-2p5uA:
12.68
1utdB-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 8 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.43A 1utdB-2p5uA:
undetectable
1utdC-2p5uA:
undetectable		 1utdB-2p5uA:
12.68
1utdC-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_C_TRPC81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.46A 1utdC-2p5uA:
undetectable
1utdD-2p5uA:
undetectable		 1utdC-2p5uA:
12.68
1utdD-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 1utdD-2p5uA:
undetectable
1utdE-2p5uA:
undetectable		 1utdD-2p5uA:
12.68
1utdE-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 8 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.43A 1utdF-2p5uA:
undetectable
1utdG-2p5uA:
undetectable		 1utdF-2p5uA:
12.68
1utdG-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_G_TRPG81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.44A 1utdG-2p5uA:
undetectable
1utdH-2p5uA:
undetectable		 1utdG-2p5uA:
12.68
1utdH-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 8 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.44A 1utdJ-2p5uA:
undetectable
1utdK-2p5uA:
undetectable		 1utdJ-2p5uA:
12.68
1utdK-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.44A 1utdA-2p5uA:
undetectable
1utdK-2p5uA:
undetectable		 1utdA-2p5uA:
12.68
1utdK-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_N_TRPN81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.47A 1utdN-2p5uA:
undetectable
1utdO-2p5uA:
undetectable		 1utdN-2p5uA:
12.68
1utdO-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		4 / 5 TYR A 217
TYR A 174
ILE A 300
GLY A 245
 None
 1.14A 1ve9A-2p5uA:
5.3		 1ve9A-2p5uA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		4 / 8 PHE A  62
THR A   6
LEU A  52
GLY A  97
 None
None
NAD  A1118 (-4.0A)
None
 0.85A 2a1oA-2p5uA:
undetectable		 2a1oA-2p5uA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		4 / 5 TYR A 217
TYR A 174
ILE A 300
GLY A 245
 None
 1.04A 2du8J-2p5uA:
5.1		 2du8J-2p5uA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 7 ALA A  74
GLY A   8
ASP A  51
LEU A  52
ARG A  53
 NAD  A1118 (-3.5A)
None
NAD  A1118 (-3.0A)
NAD  A1118 (-4.0A)
None
 1.31A 2uyqA-2p5uA:
4.6		 2uyqA-2p5uA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 7 GLY A   8
ASP A  31
ASP A  51
LEU A  52
ARG A  53
 None
NAD  A1118 (-2.7A)
NAD  A1118 (-3.0A)
NAD  A1118 (-4.0A)
None
 1.12A 2uyqA-2p5uA:
4.6		 2uyqA-2p5uA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 11 GLY A 171
GLY A 241
ARG A 215
ALA A 184
GLU A 183
 None
None
None
NAD  A1118 (-3.2A)
None
 1.09A 3g88A-2p5uA:
4.0		 3g88A-2p5uA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 11 GLY A 171
GLY A 241
ARG A 215
ALA A 184
GLU A 183
 None
None
None
NAD  A1118 (-3.2A)
None
 1.11A 3g88B-2p5uA:
4.2		 3g88B-2p5uA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 171
GLY A 241
ARG A 215
ALA A 184
GLU A 183
 None
None
None
NAD  A1118 (-3.2A)
None
 1.08A 3g8bA-2p5uA:
4.0		 3g8bA-2p5uA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 175
GLY A 299
ALA A 188
GLY A 185
ILE A 300
 None
 0.96A 3ku1A-2p5uA:
5.0		 3ku1A-2p5uA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 175
GLY A 299
ALA A 188
GLY A 185
ILE A 300
 None
 0.94A 3ku1C-2p5uA:
5.1		 3ku1C-2p5uA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 12 GLY A   7
ILE A  16
ASP A  31
ASP A  51
LEU A  52
 NAD  A1118 (-3.4A)
None
NAD  A1118 (-2.7A)
NAD  A1118 (-3.0A)
NAD  A1118 (-4.0A)
 1.11A 3q87B-2p5uA:
5.6		 3q87B-2p5uA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 12 ASP A  51
ARG A  53
ALA A 144
THR A 117
ALA A  77
 NAD  A1118 (-3.0A)
None
None
NAD  A1118 ( 4.7A)
NAD  A1118 (-3.4A)
 1.32A 3ua1A-2p5uA:
undetectable		 3ua1A-2p5uA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		3 / 3 ARG A  66
GLU A  64
PHE A  48
 None
 0.80A 4kszA-2p5uA:
undetectable		 4kszA-2p5uA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 ALA A  74
THR A   6
GLY A  97
GLY A  96
ASP A  51
 NAD  A1118 (-3.5A)
None
None
None
NAD  A1118 (-3.0A)
 0.98A 4qvmK-2p5uA:
undetectable
4qvmL-2p5uA:
undetectable		 4qvmK-2p5uA:
22.47
4qvmL-2p5uA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 ALA A  74
THR A   6
GLY A  97
GLY A  96
ASP A  51
 NAD  A1118 (-3.5A)
None
None
None
NAD  A1118 (-3.0A)
 0.98A 4qvmY-2p5uA:
undetectable
4qvmZ-2p5uA:
undetectable		 4qvmY-2p5uA:
22.47
4qvmZ-2p5uA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 ALA A  74
THR A   6
GLY A  97
GLY A  96
ASP A  51
 NAD  A1118 (-3.5A)
None
None
None
NAD  A1118 (-3.0A)
 1.01A 4qvpK-2p5uA:
undetectable
4qvpL-2p5uA:
undetectable		 4qvpK-2p5uA:
22.47
4qvpL-2p5uA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 ALA A  74
THR A   6
GLY A  97
GLY A  96
ASP A  51
 NAD  A1118 (-3.5A)
None
None
None
NAD  A1118 (-3.0A)
 1.01A 4qvpY-2p5uA:
undetectable
4qvpZ-2p5uA:
undetectable		 4qvpY-2p5uA:
22.47
4qvpZ-2p5uA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		3 / 3 ARG A 138
THR A 134
TRP A 135
 None
 1.10A 4ug5A-2p5uA:
undetectable		 4ug5A-2p5uA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 11 LEU A   4
ASP A  31
ALA A  28
VAL A  17
ILE A  12
 None
NAD  A1118 (-2.7A)
None
None
NAD  A1118 (-3.8A)
 1.38A 4uuuA-2p5uA:
undetectable
4uuuB-2p5uA:
undetectable		 4uuuA-2p5uA:
20.07
4uuuB-2p5uA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		3 / 3 VAL A 113
PHE A 232
ARG A  23
 None
 0.95A 4xr4B-2p5uA:
8.3		 4xr4B-2p5uA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 11 ALA A  74
THR A   6
GLY A  97
GLY A  96
ASP A  51
 NAD  A1118 (-3.5A)
None
None
None
NAD  A1118 (-3.0A)
 1.01A 5bxnK-2p5uA:
undetectable
5bxnL-2p5uA:
undetectable		 5bxnK-2p5uA:
22.47
5bxnL-2p5uA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		4 / 5 GLU A 183
ASP A 274
VAL A 186
ALA A 184
 None
None
None
NAD  A1118 (-3.2A)
 1.47A 5dl9A-2p5uA:
undetectable		 5dl9A-2p5uA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eeuA-2p5uA:
undetectable
5eeuB-2p5uA:
undetectable		 5eeuA-2p5uA:
12.68
5eeuB-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eeuB-2p5uA:
undetectable
5eeuC-2p5uA:
undetectable		 5eeuB-2p5uA:
12.68
5eeuC-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eeuC-2p5uA:
undetectable
5eeuD-2p5uA:
undetectable		 5eeuC-2p5uA:
12.68
5eeuD-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.39A 5eeuD-2p5uA:
undetectable
5eeuE-2p5uA:
undetectable		 5eeuD-2p5uA:
12.68
5eeuE-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eeuE-2p5uA:
undetectable
5eeuF-2p5uA:
undetectable		 5eeuE-2p5uA:
12.68
5eeuF-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.46A 5eeuG-2p5uA:
undetectable
5eeuH-2p5uA:
undetectable		 5eeuG-2p5uA:
12.68
5eeuH-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eeuH-2p5uA:
undetectable
5eeuI-2p5uA:
undetectable		 5eeuH-2p5uA:
12.68
5eeuI-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 5eeuA-2p5uA:
undetectable
5eeuK-2p5uA:
undetectable		 5eeuA-2p5uA:
12.68
5eeuK-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eevB-2p5uA:
undetectable
5eevC-2p5uA:
undetectable		 5eevB-2p5uA:
12.68
5eevC-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eevC-2p5uA:
undetectable
5eevD-2p5uA:
undetectable		 5eevC-2p5uA:
12.68
5eevD-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.39A 5eevD-2p5uA:
undetectable
5eevE-2p5uA:
undetectable		 5eevD-2p5uA:
12.68
5eevE-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eevE-2p5uA:
undetectable
5eevF-2p5uA:
undetectable		 5eevE-2p5uA:
12.68
5eevF-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.46A 5eevG-2p5uA:
undetectable
5eevH-2p5uA:
undetectable		 5eevG-2p5uA:
12.68
5eevH-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eevH-2p5uA:
undetectable
5eevI-2p5uA:
undetectable		 5eevH-2p5uA:
12.68
5eevI-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 5eevA-2p5uA:
undetectable
5eevK-2p5uA:
undetectable		 5eevA-2p5uA:
12.68
5eevK-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eewB-2p5uA:
undetectable
5eewC-2p5uA:
undetectable		 5eewB-2p5uA:
12.68
5eewC-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eewC-2p5uA:
undetectable
5eewD-2p5uA:
undetectable		 5eewC-2p5uA:
12.68
5eewD-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.39A 5eewD-2p5uA:
undetectable
5eewE-2p5uA:
undetectable		 5eewD-2p5uA:
12.68
5eewE-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eewE-2p5uA:
undetectable
5eewF-2p5uA:
undetectable		 5eewE-2p5uA:
12.68
5eewF-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.46A 5eewG-2p5uA:
undetectable
5eewH-2p5uA:
undetectable		 5eewG-2p5uA:
12.68
5eewH-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 5eewA-2p5uA:
undetectable
5eewK-2p5uA:
undetectable		 5eewA-2p5uA:
12.68
5eewK-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eexB-2p5uA:
undetectable
5eexC-2p5uA:
undetectable		 5eexB-2p5uA:
12.68
5eexC-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eexC-2p5uA:
undetectable
5eexD-2p5uA:
undetectable		 5eexC-2p5uA:
12.68
5eexD-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.39A 5eexD-2p5uA:
undetectable
5eexE-2p5uA:
undetectable		 5eexD-2p5uA:
12.68
5eexE-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eexE-2p5uA:
undetectable
5eexF-2p5uA:
undetectable		 5eexE-2p5uA:
12.68
5eexF-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.47A 5eexG-2p5uA:
undetectable
5eexH-2p5uA:
undetectable		 5eexG-2p5uA:
12.68
5eexH-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 5eexA-2p5uA:
undetectable
5eexK-2p5uA:
undetectable		 5eexA-2p5uA:
12.68
5eexK-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.48A 5eexQ-2p5uA:
undetectable
5eexR-2p5uA:
undetectable		 5eexQ-2p5uA:
12.68
5eexR-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eeyB-2p5uA:
undetectable
5eeyC-2p5uA:
undetectable		 5eeyB-2p5uA:
12.68
5eeyC-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eeyC-2p5uA:
undetectable
5eeyD-2p5uA:
undetectable		 5eeyC-2p5uA:
12.68
5eeyD-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.39A 5eeyD-2p5uA:
undetectable
5eeyE-2p5uA:
undetectable		 5eeyD-2p5uA:
12.68
5eeyE-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eeyE-2p5uA:
undetectable
5eeyF-2p5uA:
undetectable		 5eeyE-2p5uA:
12.68
5eeyF-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.46A 5eeyG-2p5uA:
undetectable
5eeyH-2p5uA:
undetectable		 5eeyG-2p5uA:
12.68
5eeyH-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eeyH-2p5uA:
undetectable
5eeyI-2p5uA:
undetectable		 5eeyH-2p5uA:
12.68
5eeyI-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 5eeyA-2p5uA:
undetectable
5eeyK-2p5uA:
undetectable		 5eeyA-2p5uA:
12.68
5eeyK-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.48A 5eeyQ-2p5uA:
undetectable
5eeyR-2p5uA:
undetectable		 5eeyQ-2p5uA:
12.68
5eeyR-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 5eezB-2p5uA:
undetectable
5eezC-2p5uA:
undetectable		 5eezB-2p5uA:
12.68
5eezC-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eezC-2p5uA:
undetectable
5eezD-2p5uA:
undetectable		 5eezC-2p5uA:
12.68
5eezD-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.39A 5eezD-2p5uA:
undetectable
5eezE-2p5uA:
undetectable		 5eezD-2p5uA:
12.68
5eezE-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eezE-2p5uA:
undetectable
5eezF-2p5uA:
undetectable		 5eezE-2p5uA:
12.68
5eezF-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.47A 5eezG-2p5uA:
undetectable
5eezH-2p5uA:
undetectable		 5eezG-2p5uA:
12.68
5eezH-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5eezH-2p5uA:
undetectable
5eezI-2p5uA:
undetectable		 5eezH-2p5uA:
12.68
5eezI-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.43A 5eezJ-2p5uA:
undetectable
5eezK-2p5uA:
undetectable		 5eezJ-2p5uA:
12.68
5eezK-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 5eezA-2p5uA:
undetectable
5eezK-2p5uA:
undetectable		 5eezA-2p5uA:
12.68
5eezK-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.48A 5eezQ-2p5uA:
undetectable
5eezR-2p5uA:
undetectable		 5eezQ-2p5uA:
12.68
5eezR-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 5ef0B-2p5uA:
undetectable
5ef0C-2p5uA:
undetectable		 5ef0B-2p5uA:
12.68
5ef0C-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5ef0C-2p5uA:
undetectable
5ef0D-2p5uA:
undetectable		 5ef0C-2p5uA:
12.68
5ef0D-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.39A 5ef0D-2p5uA:
undetectable
5ef0E-2p5uA:
undetectable		 5ef0D-2p5uA:
12.68
5ef0E-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5ef0E-2p5uA:
undetectable
5ef0F-2p5uA:
undetectable		 5ef0E-2p5uA:
12.68
5ef0F-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5ef0H-2p5uA:
undetectable
5ef0I-2p5uA:
undetectable		 5ef0H-2p5uA:
12.68
5ef0I-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.43A 5ef0J-2p5uA:
undetectable
5ef0K-2p5uA:
undetectable		 5ef0J-2p5uA:
12.68
5ef0K-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 5ef0A-2p5uA:
undetectable
5ef0K-2p5uA:
undetectable		 5ef0A-2p5uA:
12.68
5ef0K-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.48A 5ef0Q-2p5uA:
undetectable
5ef0R-2p5uA:
undetectable		 5ef0Q-2p5uA:
12.68
5ef0R-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5ef1B-2p5uA:
undetectable
5ef1C-2p5uA:
undetectable		 5ef1B-2p5uA:
12.68
5ef1C-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5ef1C-2p5uA:
undetectable
5ef1D-2p5uA:
undetectable		 5ef1C-2p5uA:
12.68
5ef1D-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.39A 5ef1D-2p5uA:
undetectable
5ef1E-2p5uA:
undetectable		 5ef1D-2p5uA:
12.68
5ef1E-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5ef1E-2p5uA:
undetectable
5ef1F-2p5uA:
undetectable		 5ef1E-2p5uA:
12.68
5ef1F-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5ef1H-2p5uA:
undetectable
5ef1I-2p5uA:
undetectable		 5ef1H-2p5uA:
12.68
5ef1I-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.43A 5ef1J-2p5uA:
undetectable
5ef1K-2p5uA:
undetectable		 5ef1J-2p5uA:
12.68
5ef1K-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 5ef1A-2p5uA:
undetectable
5ef1K-2p5uA:
undetectable		 5ef1A-2p5uA:
12.68
5ef1K-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.48A 5ef1Q-2p5uA:
undetectable
5ef1R-2p5uA:
undetectable		 5ef1Q-2p5uA:
12.68
5ef1R-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5ef2B-2p5uA:
undetectable
5ef2C-2p5uA:
undetectable		 5ef2B-2p5uA:
12.68
5ef2C-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5ef2C-2p5uA:
undetectable
5ef2D-2p5uA:
undetectable		 5ef2C-2p5uA:
12.68
5ef2D-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.39A 5ef2D-2p5uA:
undetectable
5ef2E-2p5uA:
undetectable		 5ef2D-2p5uA:
12.68
5ef2E-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5ef2E-2p5uA:
undetectable
5ef2F-2p5uA:
undetectable		 5ef2E-2p5uA:
12.68
5ef2F-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5ef2H-2p5uA:
undetectable
5ef2I-2p5uA:
undetectable		 5ef2H-2p5uA:
12.68
5ef2I-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.43A 5ef2J-2p5uA:
undetectable
5ef2K-2p5uA:
undetectable		 5ef2J-2p5uA:
12.68
5ef2K-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 5ef2A-2p5uA:
undetectable
5ef2K-2p5uA:
undetectable		 5ef2A-2p5uA:
12.68
5ef2K-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.48A 5ef2Q-2p5uA:
undetectable
5ef2R-2p5uA:
undetectable		 5ef2Q-2p5uA:
12.68
5ef2R-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 5ef3B-2p5uA:
undetectable
5ef3C-2p5uA:
undetectable		 5ef3B-2p5uA:
12.68
5ef3C-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5ef3C-2p5uA:
undetectable
5ef3D-2p5uA:
undetectable		 5ef3C-2p5uA:
12.68
5ef3D-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.39A 5ef3D-2p5uA:
undetectable
5ef3E-2p5uA:
undetectable		 5ef3D-2p5uA:
12.68
5ef3E-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5ef3E-2p5uA:
undetectable
5ef3F-2p5uA:
undetectable		 5ef3E-2p5uA:
12.68
5ef3F-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.42A 5ef3H-2p5uA:
undetectable
5ef3I-2p5uA:
undetectable		 5ef3H-2p5uA:
12.68
5ef3I-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.43A 5ef3J-2p5uA:
undetectable
5ef3K-2p5uA:
undetectable		 5ef3J-2p5uA:
12.68
5ef3K-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.41A 5ef3A-2p5uA:
undetectable
5ef3K-2p5uA:
undetectable		 5ef3A-2p5uA:
12.68
5ef3K-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.48A 5ef3Q-2p5uA:
undetectable
5ef3R-2p5uA:
undetectable		 5ef3Q-2p5uA:
12.68
5ef3R-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		3 / 3 ARG A 138
THR A 134
TRP A 135
 None
 1.11A 5g6cA-2p5uA:
undetectable		 5g6cA-2p5uA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 11 GLY A 171
ALA A 120
TYR A 143
LEU A 275
GLU A 183
 None
None
NAD  A1118 (-4.4A)
None
None
 1.17A 5hw4B-2p5uA:
undetectable		 5hw4B-2p5uA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 171
ALA A 120
TYR A 143
LEU A 275
GLU A 183
 None
None
NAD  A1118 (-4.4A)
None
None
 1.20A 5hw4C-2p5uA:
1.2		 5hw4C-2p5uA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 11 ALA A  74
THR A   6
GLY A  97
GLY A  96
ASP A  51
 NAD  A1118 (-3.5A)
None
None
None
NAD  A1118 (-3.0A)
 0.99A 5lf3K-2p5uA:
undetectable
5lf3L-2p5uA:
undetectable		 5lf3K-2p5uA:
24.58
5lf3L-2p5uA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 11 ALA A  74
THR A   6
GLY A  97
GLY A  96
ASP A  51
 NAD  A1118 (-3.5A)
None
None
None
NAD  A1118 (-3.0A)
 0.98A 5lf3Y-2p5uA:
undetectable
5lf3Z-2p5uA:
undetectable		 5lf3Y-2p5uA:
24.58
5lf3Z-2p5uA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		4 / 7 ARG A  60
PHE A  62
LEU A 100
SER A  71
 None
 1.14A 5uxcA-2p5uA:
undetectable		 5uxcA-2p5uA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 2p5u UDP-GLUCOSE
4-EPIMERASE
(Thermus
thermophilus) 		5 / 10 VAL A 166
GLY A 236
ALA A 230
LEU A 168
ASN A 239
 None
 0.89A 5x6yB-2p5uA:
2.3		 5x6yB-2p5uA:
17.56