SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN
(Homo
sapiens) 		5 / 12 PHE A 204
HIS A 129
LEU A  10
LEU A 211
TYR A 212
 None
 1.31A 1fm6X-2p5xA:
undetectable		 1fm6X-2p5xA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN
(Homo
sapiens) 		5 / 11 GLY A 175
GLY A 174
VAL A 121
LEU A 114
LEU A 185
 None
 0.80A 1mx1A-2p5xA:
undetectable		 1mx1A-2p5xA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 175
GLY A 174
VAL A 121
LEU A 114
LEU A 185
 None
 0.90A 1mx1D-2p5xA:
undetectable		 1mx1D-2p5xA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN
(Homo
sapiens) 		3 / 3 LEU A  33
PHE A  35
ARG A  23
 None
 0.81A 1xdkB-2p5xA:
undetectable		 1xdkB-2p5xA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN
(Homo
sapiens) 		3 / 3 LEU A  33
PHE A  35
ARG A  23
 None
 0.82A 1xdkF-2p5xA:
undetectable		 1xdkF-2p5xA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN
(Homo
sapiens) 		4 / 5 PRO A  39
VAL A  37
THR A 123
GLY A 198
 None
 1.17A 3elzB-2p5xA:
1.1		 3elzB-2p5xA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN
(Homo
sapiens) 		4 / 5 CYH A 205
LEU A  33
LEU A  17
LEU A  10
 None
 1.16A 4n09D-2p5xA:
undetectable		 4n09D-2p5xA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN
(Homo
sapiens) 		5 / 11 ARG A 113
LEU A 114
ARG A 117
LEU A 160
LEU A  98
 None
 1.43A 4or0A-2p5xA:
2.5		 4or0A-2p5xA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN
(Homo
sapiens) 		3 / 3 ILE A  27
ASP A 192
ARG A  23
 None
 0.79A 4pstA-2p5xA:
undetectable		 4pstA-2p5xA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN
(Homo
sapiens) 		5 / 8 THR A 123
ILE A 127
VAL A  37
LEU A  17
PHE A 204
 None
 1.43A 4r38B-2p5xA:
1.7		 4r38B-2p5xA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN
(Homo
sapiens) 		5 / 12 PHE A 204
HIS A 129
LEU A  10
LEU A 211
TYR A 212
 None
 1.29A 5y2oA-2p5xA:
undetectable		 5y2oA-2p5xA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  35
ILE A  85
VAL A 125
SER A  19
VAL A  37
 None
None
None
PO4  A 301 (-2.3A)
None
 0.91A 6ap6A-2p5xA:
undetectable		 6ap6A-2p5xA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  35
ILE A  85
VAL A 125
SER A  19
VAL A  37
 None
None
None
PO4  A 301 (-2.3A)
None
 0.91A 6ap6B-2p5xA:
undetectable		 6ap6B-2p5xA:
21.00