SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		5 / 11 THR X 384
THR X 448
VAL X 467
VAL X 409
VAL X 389
 None
 1.22A 1akdA-2p5zX:
undetectable		 1akdA-2p5zX:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		5 / 10 LEU X  37
GLY X 323
TRP X 183
GLY X 205
TYR X 200
 None
 1.25A 1ruaH-2p5zX:
undetectable
1ruaL-2p5zX:
undetectable		 1ruaH-2p5zX:
18.99
1ruaL-2p5zX:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		4 / 8 SER X  98
SER X  96
GLN X  46
LYS X  52
 None
 1.11A 2cmlB-2p5zX:
undetectable		 2cmlB-2p5zX:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		5 / 12 PRO X 364
VAL X 341
GLN X 314
THR X 359
PHE X 360
 None
 1.23A 2v95A-2p5zX:
undetectable		 2v95A-2p5zX:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		3 / 3 ILE X 197
PHE X 150
HIS X 141
 None
 0.73A 3h0aA-2p5zX:
undetectable		 3h0aA-2p5zX:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		4 / 8 GLU X  35
TYR X  43
LEU X 108
PHE X  41
 None
 1.13A 3rqwC-2p5zX:
undetectable
3rqwD-2p5zX:
undetectable		 3rqwC-2p5zX:
21.12
3rqwD-2p5zX:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		4 / 8 GLU X  35
TYR X  43
LEU X 108
PHE X  41
 None
 1.14A 3rqwF-2p5zX:
undetectable
3rqwJ-2p5zX:
undetectable		 3rqwF-2p5zX:
21.12
3rqwJ-2p5zX:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		4 / 7 VAL X 173
LEU X 170
LEU X 115
ILE X 197
 None
 0.90A 3u5kB-2p5zX:
undetectable		 3u5kB-2p5zX:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		4 / 5 VAL X 173
LEU X 170
LEU X 115
ILE X 197
 None
 0.95A 4a9jC-2p5zX:
undetectable		 4a9jC-2p5zX:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		5 / 12 ARG X 372
PRO X 373
THR X  39
GLN X  36
LEU X 342
 None
 1.39A 4abzA-2p5zX:
undetectable		 4abzA-2p5zX:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		4 / 6 THR X 344
ARG X  83
ILE X 326
LEU X 311
 None
 0.91A 4ac9C-2p5zX:
2.4		 4ac9C-2p5zX:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		4 / 6 THR X 344
ARG X  83
ILE X 326
LEU X 311
 None
 0.92A 4acbC-2p5zX:
2.4		 4acbC-2p5zX:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		4 / 8 LEU X 358
ILE X 326
VAL X 328
GLY X 313
 None
 0.76A 4eq4B-2p5zX:
undetectable		 4eq4B-2p5zX:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		4 / 7 ARG X 159
PRO X 373
SER X  38
VAL X 180
 None
 1.48A 4kmmA-2p5zX:
undetectable		 4kmmA-2p5zX:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		3 / 3 ARG X 368
LEU X 305
GLU X 302
 None
 0.64A 4l3gF-2p5zX:
undetectable		 4l3gF-2p5zX:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		4 / 7 VAL X 228
ILE X 326
ILE X 343
ALA X 362
 None
 0.80A 4lv9A-2p5zX:
undetectable		 4lv9A-2p5zX:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		5 / 8 VAL X 173
LEU X 170
LEU X 115
ASP X 147
ILE X 197
 None
 1.23A 4lzrA-2p5zX:
undetectable		 4lzrA-2p5zX:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		4 / 6 GLU X  35
TYR X  43
LEU X 108
PHE X  41
 None
 1.33A 4twdF-2p5zX:
0.5
4twdG-2p5zX:
undetectable		 4twdF-2p5zX:
20.33
4twdG-2p5zX:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		5 / 10 ASN X 458
ALA X 122
ILE X 132
LEU X 176
TYR X 124
 None
 1.22A 4xj7A-2p5zX:
undetectable
4xj7B-2p5zX:
undetectable		 4xj7A-2p5zX:
22.18
4xj7B-2p5zX:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		5 / 11 PHE X 150
GLY X 181
VAL X 133
LEU X 115
PHE X 184
 None
 1.06A 4zmeA-2p5zX:
undetectable		 4zmeA-2p5zX:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		4 / 8 ARG X  42
TYR X  43
ASP X  63
GLY X  64
 None
 0.85A 5nooD-2p5zX:
undetectable		 5nooD-2p5zX:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 2p5z TYPE VI SECRETION
SYSTEM COMPONENT
(Escherichia
coli) 		3 / 3 TYR X 356
HIS X  15
PHE X  31
 None
 0.95A 6esmA-2p5zX:
undetectable		 6esmA-2p5zX:
12.02