SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p67'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2p67 LAO/AO TRANSPORT
SYSTEM KINASE
(Escherichia
coli) 		5 / 12 ILE A 246
LEU A  71
SER A 173
ILE A 172
ILE A 249
 None
 0.99A 1dhiA-2p67A:
3.3		 1dhiA-2p67A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2p67 LAO/AO TRANSPORT
SYSTEM KINASE
(Escherichia
coli) 		5 / 12 ILE A 246
LEU A  71
SER A 173
ILE A 172
ILE A 249
 None
 1.02A 1draA-2p67A:
3.1		 1draA-2p67A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2p67 LAO/AO TRANSPORT
SYSTEM KINASE
(Escherichia
coli) 		4 / 4 LEU A 196
VAL A 198
ILE A 197
TRP A 231
 None
 1.19A 1s9qB-2p67A:
undetectable		 1s9qB-2p67A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2p67 LAO/AO TRANSPORT
SYSTEM KINASE
(Escherichia
coli) 		4 / 8 THR A 154
VAL A 164
VAL A 122
VAL A  90
 None
 0.93A 1t86A-2p67A:
undetectable		 1t86A-2p67A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 2p67 LAO/AO TRANSPORT
SYSTEM KINASE
(Escherichia
coli) 		5 / 12 ILE A 246
LEU A 196
VAL A 198
GLU A 248
LEU A 236
 None
 1.30A 2bxfB-2p67A:
undetectable		 2bxfB-2p67A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2p67 LAO/AO TRANSPORT
SYSTEM KINASE
(Escherichia
coli) 		5 / 12 ILE A 246
LEU A  71
SER A 173
ILE A 172
ILE A 249
 None
 1.02A 2drcA-2p67A:
3.3		 2drcA-2p67A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 2p67 LAO/AO TRANSPORT
SYSTEM KINASE
(Escherichia
coli) 		5 / 9 LEU A  57
VAL A  87
ILE A 246
VAL A 149
ILE A 151
 None
 1.01A 2o4pB-2p67A:
undetectable		 2o4pB-2p67A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 2p67 LAO/AO TRANSPORT
SYSTEM KINASE
(Escherichia
coli) 		5 / 10 ILE A 254
PHE A  74
LEU A  83
VAL A  85
LEU A  78
 None
 1.31A 2w98A-2p67A:
undetectable		 2w98A-2p67A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2p67 LAO/AO TRANSPORT
SYSTEM KINASE
(Escherichia
coli) 		4 / 7 THR A  60
VAL A 152
THR A 154
VAL A  90
 None
 0.51A 3em0B-2p67A:
undetectable		 3em0B-2p67A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2p67 LAO/AO TRANSPORT
SYSTEM KINASE
(Escherichia
coli) 		5 / 12 GLU A  72
ASN A 109
ASP A 247
ILE A 246
GLY A  75
 None
 1.19A 3ps9A-2p67A:
undetectable		 3ps9A-2p67A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 2p67 LAO/AO TRANSPORT
SYSTEM KINASE
(Escherichia
coli) 		5 / 10 ILE A 246
LEU A  77
VAL A 149
ILE A 172
LEU A  57
 None
 0.82A 5ienB-2p67A:
undetectable		 5ienB-2p67A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 2p67 LAO/AO TRANSPORT
SYSTEM KINASE
(Escherichia
coli) 		4 / 7 LEU A  22
LEU A  14
ALA A 144
THR A  54
 None
 0.84A 6a7jA-2p67A:
undetectable		 6a7jA-2p67A:
14.73