SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p68'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aquifex
aeolicus) 		4 / 6 ALA A  30
TRP A 136
ARG A 138
LEU A  27
 None
 1.16A 1gahA-2p68A:
undetectable		 1gahA-2p68A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aquifex
aeolicus) 		5 / 8 THR A 120
GLY A 119
GLY A 163
PHE A 167
LEU A 164
 None
 1.37A 1jhvA-2p68A:
2.5		 1jhvA-2p68A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aquifex
aeolicus) 		5 / 9 THR A 120
GLY A 119
GLY A 163
PHE A 167
LEU A 164
 None
 1.35A 1jhyA-2p68A:
2.3		 1jhyA-2p68A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aquifex
aeolicus) 		5 / 9 THR A 120
GLY A 119
GLY A 163
PHE A 167
LEU A 164
 None
 1.32A 1l4nA-2p68A:
2.4		 1l4nA-2p68A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aquifex
aeolicus) 		3 / 3 ARG A  43
VAL A  34
GLY A  56
 None
 0.55A 2avvE-2p68A:
undetectable		 2avvE-2p68A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aquifex
aeolicus) 		6 / 12 GLN A 209
TYR A 157
ILE A 190
GLY A 188
ILE A 210
GLY A 216
 None
 1.04A 3bwcA-2p68A:
5.0		 3bwcA-2p68A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aquifex
aeolicus) 		4 / 6 GLU A 111
ASP A 108
ASP A  98
LYS A  99
 None
 1.23A 3pocB-2p68A:
undetectable		 3pocB-2p68A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aquifex
aeolicus) 		4 / 5 SER A 144
ILE A  19
TYR A 157
GLY A 188
 None
 1.02A 3uboB-2p68A:
6.5		 3uboB-2p68A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aquifex
aeolicus) 		5 / 11 ILE A  23
ILE A  19
GLY A  18
VAL A 243
GLY A 216
 None
 1.07A 4ac9B-2p68A:
6.0
4ac9C-2p68A:
3.7		 4ac9B-2p68A:
21.96
4ac9C-2p68A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aquifex
aeolicus) 		5 / 12 LEU A 232
ALA A 233
LEU A 226
ILE A  88
LEU A  27
 None
 1.14A 4j24D-2p68A:
undetectable		 4j24D-2p68A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aquifex
aeolicus) 		4 / 8 PRO A 187
VAL A 221
VAL A 146
GLY A 147
 None
 0.87A 4mk4A-2p68A:
3.1		 4mk4A-2p68A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aquifex
aeolicus) 		4 / 8 SER A 144
VAL A 145
VAL A 152
GLY A 153
 None
 0.69A 4mk4A-2p68A:
3.1		 4mk4A-2p68A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aquifex
aeolicus) 		3 / 3 ARG A  17
THR A 192
ASP A 193
 None
 0.93A 5g5gA-2p68A:
undetectable
5g5gB-2p68A:
undetectable		 5g5gA-2p68A:
24.52
5g5gB-2p68A:
20.18