SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p6d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 2p6d DIPHTHINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 10 ALA A 181
VAL A 203
VAL A 205
ILE A 237
VAL A 238
 None
 1.08A 2nnjA-2p6dA:
undetectable		 2nnjA-2p6dA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 2p6d DIPHTHINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A 205
ILE A 116
LEU A 163
SER A  37
THR A 123
 None
SAH  A 301 (-3.8A)
None
SAH  A 301 (-3.0A)
None
 1.13A 2w3vA-2p6dA:
undetectable		 2w3vA-2p6dA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2p6d DIPHTHINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 9 MET A 182
ALA A 178
VAL A 203
ILE A 152
PHE A 197
 None
 1.49A 3fl9D-2p6dA:
undetectable		 3fl9D-2p6dA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 2p6d DIPHTHINE SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A  33
HIS A  94
THR A  36
 None
 0.74A 3hkuA-2p6dA:
undetectable		 3hkuA-2p6dA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 2p6d DIPHTHINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A   6
LEU A  83
THR A  17
ILE A  16
 None
 0.74A 3p50A-2p6dA:
undetectable		 3p50A-2p6dA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 2p6d DIPHTHINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A   6
LEU A  83
THR A  17
ILE A  16
 None
 0.74A 3p50B-2p6dA:
undetectable		 3p50B-2p6dA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 2p6d DIPHTHINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A   6
LEU A  83
THR A  17
ILE A  16
 None
 0.75A 3p50C-2p6dA:
undetectable		 3p50C-2p6dA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 2p6d DIPHTHINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A   6
LEU A  83
THR A  17
ILE A  16
 None
 0.74A 3p50D-2p6dA:
undetectable		 3p50D-2p6dA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 2p6d DIPHTHINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A   6
LEU A  83
THR A  17
ILE A  16
 None
 0.75A 3p50E-2p6dA:
undetectable		 3p50E-2p6dA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2p6d DIPHTHINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A 121
VAL A 245
GLU A 246
TYR A 249
 None
 0.70A 4fgzA-2p6dA:
undetectable		 4fgzA-2p6dA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 2p6d DIPHTHINE SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 258
LEU A 261
GLU A 259
 None
 0.72A 4l3gF-2p6dA:
undetectable		 4l3gF-2p6dA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p6d DIPHTHINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 9 GLU A  96
LEU A   3
LEU A  72
ILE A  70
 None
 0.95A 4xtaA-2p6dA:
undetectable		 4xtaA-2p6dA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2p6d DIPHTHINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 5 TYR A 220
LEU A 242
PRO A 239
LEU A 261
 None
 1.29A 5eshA-2p6dA:
undetectable		 5eshA-2p6dA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2p6d DIPHTHINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  86
VAL A  90
SER A 115
PHE A 165
ALA A 209
 SAH  A 301 ( 3.7A)
SAH  A 301 (-4.0A)
SAH  A 301 (-2.7A)
SAH  A 301 (-4.8A)
SAH  A 301 (-3.6A)
 1.01A 5n0oA-2p6dA:
6.7		 5n0oA-2p6dA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 2p6d DIPHTHINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 5 ALA A  32
VAL A  30
PHE A  34
ILE A  51
 None
 0.97A 5of1A-2p6dA:
undetectable		 5of1A-2p6dA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 2p6d DIPHTHINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 5 ALA A  32
VAL A  30
PHE A  34
ILE A  51
 None
 1.04A 5of1B-2p6dA:
undetectable		 5of1B-2p6dA:
16.73