SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p6h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2p6h HYPOTHETICAL PROTEIN
(Aeropyrum
pernix) 		4 / 4 ASN A  90
SER A  96
ALA A  47
VAL A 117
 None
 0.97A 4x1kC-2p6hA:
undetectable		 4x1kC-2p6hA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2p6h HYPOTHETICAL PROTEIN
(Aeropyrum
pernix) 		5 / 12 ILE A  93
GLY A  89
HIS A  87
ALA A  49
VAL A  16
 None
 1.14A 5n0oA-2p6hA:
undetectable		 5n0oA-2p6hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2p6h HYPOTHETICAL PROTEIN
(Aeropyrum
pernix) 		6 / 12 ILE A  93
GLY A  89
HIS A  87
ALA A  47
ALA A  49
VAL A  16
 None
 1.23A 5n0oB-2p6hA:
undetectable		 5n0oB-2p6hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2p6h HYPOTHETICAL PROTEIN
(Aeropyrum
pernix) 		5 / 12 ILE A  93
GLY A  89
HIS A  87
ALA A  49
VAL A  16
 None
 1.15A 5n0rA-2p6hA:
undetectable		 5n0rA-2p6hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2p6h HYPOTHETICAL PROTEIN
(Aeropyrum
pernix) 		6 / 12 ILE A  93
GLY A  89
HIS A  87
ALA A  47
ALA A  49
VAL A  16
 None
 1.25A 5n0tB-2p6hA:
undetectable		 5n0tB-2p6hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2p6h HYPOTHETICAL PROTEIN
(Aeropyrum
pernix) 		5 / 12 ILE A  93
GLY A  89
HIS A  87
ALA A  49
VAL A  16
 None
 1.20A 5n0xB-2p6hA:
undetectable		 5n0xB-2p6hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2p6h HYPOTHETICAL PROTEIN
(Aeropyrum
pernix) 		4 / 4 ASN A  90
SER A  96
ALA A  47
VAL A 117
 None
 0.99A 5nm5A-2p6hA:
undetectable		 5nm5A-2p6hA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2p6h HYPOTHETICAL PROTEIN
(Aeropyrum
pernix) 		3 / 3 THR A  10
GLU A 118
HIS A  43
 None
None
SO4  A 501 (-4.4A)
 0.92A 5xioA-2p6hA:
undetectable		 5xioA-2p6hA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2p6h HYPOTHETICAL PROTEIN
(Aeropyrum
pernix) 		3 / 3 THR A  10
GLU A 118
HIS A  43
 None
None
SO4  A 501 (-4.4A)
 0.87A 5xiqB-2p6hA:
undetectable		 5xiqB-2p6hA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2p6h HYPOTHETICAL PROTEIN
(Aeropyrum
pernix) 		3 / 3 THR A  10
GLU A 118
HIS A  43
 None
None
SO4  A 501 (-4.4A)
 0.92A 5xiqD-2p6hA:
undetectable		 5xiqD-2p6hA:
14.75