SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p6n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	2p6n	ATP-DEPENDENT RNA HELICASE DDX41 (Homo sapiens)	5 / 9	LEU A 545 VAL A 559 VAL A 412 TYR A 414 LEU A 566	None	1.21A	1ikvA-2p6nA: undetectable	1ikvA-2p6nA: 15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FAK_A_SAMA201_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H)	2p6n	ATP-DEPENDENT RNA HELICASE DDX41 (Homo sapiens)	5 / 10	LEU A 436 ILE A 505 ILE A 501 PHE A 438 THR A 533	None	0.98A	4fakA-2p6nA: undetectable	4fakA-2p6nA: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2p6n	ATP-DEPENDENT RNA HELICASE DDX41 (Homo sapiens)	5 / 10	LEU A 545 VAL A 559 VAL A 412 TYR A 414 LEU A 566	None	1.27A	6bsgA-2p6nA: undetectable	6bsgA-2p6nA: 19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2p6n	ATP-DEPENDENT RNA HELICASE DDX41 (Homo sapiens)	5 / 10	LEU A 545 VAL A 559 VAL A 412 TYR A 414 LEU A 566	None	1.27A	6bsjA-2p6nA: undetectable	6bsjA-2p6nA: 19.64

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1IKV_A_EFZA2000_1","POL POLYPROTEIN","2p6n","ATP-DEPENDENT RNA HELICASE DDX41","Homo sapiens",5,"LEU A 545;VAL A 559;VAL A 412;TYR A 414;LEU A 566","None","1.21A","1ikvA-2p6nA:undetectable","1ikvA-2p6nA:15.90"],["4FAK_A_SAMA201_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H","2p6n","ATP-DEPENDENT RNA HELICASE DDX41","Homo sapiens",5,"LEU A 436;ILE A 505;ILE A 501;PHE A 438;THR A 533","None","0.98A","4fakA-2p6nA:undetectable","4fakA-2p6nA:22.86"],["6BSG_A_EFZA601_1","REVERSE TRANSCRIPTASE P66 SUBUNIT","2p6n","ATP-DEPENDENT RNA HELICASE DDX41","Homo sapiens",5,"LEU A 545;VAL A 559;VAL A 412;TYR A 414;LEU A 566","None","1.27A","6bsgA-2p6nA:undetectable","6bsgA-2p6nA:19.64"],["6BSJ_A_EFZA601_1","REVERSE TRANSCRIPTASE P66 SUBUNIT","2p6n","ATP-DEPENDENT RNA HELICASE DDX41","Homo sapiens",5,"LEU A 545;VAL A 559;VAL A 412;TYR A 414;LEU A 566","None","1.27A","6bsjA-2p6nA:undetectable","6bsjA-2p6nA:19.64"]]