SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p6p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		3 / 3 TRP A 136
ARG A 190
THR A 135
 GOL  A1005 ( 3.7A)
None
None
 0.97A 1df7A-2p6pA:
undetectable		 1df7A-2p6pA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		5 / 12 LEU A  20
LEU A  17
HIS A 382
LEU A 169
ILE A 171
 None
 1.37A 1fmlA-2p6pA:
2.5		 1fmlA-2p6pA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 6 SER A  95
ALA A  92
THR A  54
ASN A  36
 None
 1.14A 1yvpB-2p6pA:
3.7		 1yvpB-2p6pA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		5 / 11 PHE A  15
ALA A  18
ALA A  21
LEU A  48
VAL A  43
 None
 0.93A 2bxeB-2p6pA:
undetectable		 2bxeB-2p6pA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 6 ILE A  62
ARG A  59
PRO A 252
SER A 217
 None
 1.34A 2qd3B-2p6pA:
4.4		 2qd3B-2p6pA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 6 LEU A 293
LEU A 296
ILE A 173
ARG A 190
 None
 1.00A 2rlfA-2p6pA:
undetectable
2rlfB-2p6pA:
undetectable		 2rlfA-2p6pA:
9.80
2rlfB-2p6pA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 7 THR A 271
PRO A 272
VAL A 275
GLU A 201
 None
 1.03A 2v2gA-2p6pA:
undetectable
2v2gB-2p6pA:
undetectable		 2v2gA-2p6pA:
20.36
2v2gB-2p6pA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 7 THR A 271
PRO A 272
VAL A 275
GLU A 201
 None
 1.05A 2v2gA-2p6pA:
undetectable
2v2gB-2p6pA:
undetectable		 2v2gA-2p6pA:
20.36
2v2gB-2p6pA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 7 THR A 271
PRO A 272
VAL A 275
GLU A 201
 None
 1.04A 2v2gC-2p6pA:
undetectable
2v2gD-2p6pA:
undetectable		 2v2gC-2p6pA:
20.36
2v2gD-2p6pA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 7 THR A 271
PRO A 272
VAL A 275
GLU A 201
 None
 1.03A 2v2gC-2p6pA:
undetectable
2v2gD-2p6pA:
undetectable		 2v2gC-2p6pA:
20.36
2v2gD-2p6pA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 8 THR A 271
PRO A 272
VAL A 275
GLU A 201
 None
 0.93A 2v41C-2p6pA:
undetectable
2v41D-2p6pA:
undetectable		 2v41C-2p6pA:
20.36
2v41D-2p6pA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 7 THR A 271
PRO A 272
VAL A 275
GLU A 201
 None
 1.00A 2v41E-2p6pA:
undetectable
2v41F-2p6pA:
undetectable		 2v41E-2p6pA:
20.36
2v41F-2p6pA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 7 THR A 271
PRO A 272
VAL A 275
GLU A 201
 None
 1.00A 2v41E-2p6pA:
undetectable
2v41F-2p6pA:
undetectable		 2v41E-2p6pA:
20.36
2v41F-2p6pA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		5 / 12 ALA A   7
ALA A  21
THR A  22
VAL A  46
GLY A  45
 None
 1.12A 2ve3B-2p6pA:
undetectable		 2ve3B-2p6pA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		5 / 12 ALA A 124
PRO A 165
THR A 115
LEU A 122
TYR A 118
 None
 1.18A 2zifB-2p6pA:
2.9		 2zifB-2p6pA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		5 / 12 VAL A 192
LEU A  17
MET A  39
MET A  33
LEU A  48
 None
 1.44A 3h52D-2p6pA:
undetectable		 3h52D-2p6pA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 6 TYR A 226
GLY A 289
HIS A 285
SER A 291
 None
GOL  A1005 ( 3.1A)
None
None
 1.08A 3tj7A-2p6pA:
undetectable
3tj7B-2p6pA:
undetectable		 3tj7A-2p6pA:
16.36
3tj7B-2p6pA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 6 TYR A 226
GLY A 289
HIS A 285
SER A 291
 None
GOL  A1005 ( 3.1A)
None
None
 1.04A 3tj7C-2p6pA:
undetectable
3tj7D-2p6pA:
undetectable		 3tj7C-2p6pA:
16.36
3tj7D-2p6pA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 6 HIS A 285
SER A 291
TYR A 226
GLY A 289
 None
None
None
GOL  A1005 ( 3.1A)
 1.05A 3tj7C-2p6pA:
undetectable
3tj7D-2p6pA:
undetectable		 3tj7C-2p6pA:
16.36
3tj7D-2p6pA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		5 / 12 TYR A 226
VAL A 221
ALA A 222
PHE A  15
SER A 225
 None
None
None
None
GOL  A1005 ( 2.7A)
 1.18A 4mm4A-2p6pA:
undetectable		 4mm4A-2p6pA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		5 / 12 TYR A 226
VAL A 221
ALA A 222
PHE A  15
SER A 225
 None
None
None
None
GOL  A1005 ( 2.7A)
 1.16A 4mm4B-2p6pA:
undetectable		 4mm4B-2p6pA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		3 / 3 ASP A 137
ARG A 317
PRO A 314
 GOL  A1005 ( 4.6A)
None
None
 0.94A 4wanC-2p6pA:
undetectable		 4wanC-2p6pA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		3 / 3 SER A 195
ALA A 193
VAL A 192
 None
 0.32A 4x20C-2p6pA:
4.9		 4x20C-2p6pA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 5 GLU A 262
ASP A 231
VAL A 255
ALA A 258
 None
 1.12A 5dl9A-2p6pA:
undetectable		 5dl9A-2p6pA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 6 PHE A   5
VAL A 112
MET A 189
ILE A 171
 None
 1.29A 5iwuA-2p6pA:
undetectable		 5iwuA-2p6pA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		5 / 12 ALA A 120
SER A  95
MET A  99
PHE A   5
GLY A 113
 None
 1.12A 5jglA-2p6pA:
5.2		 5jglA-2p6pA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 5 PRO A 306
ALA A 287
ALA A 315
LEU A 303
 None
 0.78A 5jncD-2p6pA:
undetectable		 5jncD-2p6pA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		5 / 12 VAL A   6
LEU A 152
LEU A 122
ALA A 120
LEU A 164
 None
 0.98A 6b0cD-2p6pA:
5.8		 6b0cD-2p6pA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		5 / 10 PHE A  88
ALA A   8
GLU A 224
GLY A   9
ILE A  62
 None
 1.22A 6bniA-2p6pA:
undetectable		 6bniA-2p6pA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 5 LEU A 122
THR A  53
PRO A 108
ARG A 107
 None
 1.39A 6ew0B-2p6pA:
1.6		 6ew0B-2p6pA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 5 LEU A 122
THR A  53
PRO A 108
ARG A 107
 None
 1.39A 6ew0D-2p6pA:
undetectable		 6ew0D-2p6pA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 5 LEU A 122
THR A  53
PRO A 108
ARG A 107
 None
 1.39A 6ew0H-2p6pA:
1.6		 6ew0H-2p6pA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 2p6p GLYCOSYL TRANSFERASE
(Streptomyces
fradiae) 		4 / 5 LEU A 122
THR A  53
PRO A 108
ARG A 107
 None
 1.39A 6ew0I-2p6pA:
1.3		 6ew0I-2p6pA:
12.60