SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 493
PHE A 494
LEU A 513
ILE A 607
LEU A 500
 None
 1.30A 1lhuA-2p6rA:
undetectable		 1lhuA-2p6rA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 4 VAL A 295
ALA A 300
LEU A 306
PHE A 301
 None
 1.12A 1q97B-2p6rA:
undetectable		 1q97B-2p6rA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 489
LEU A 462
TRP A 465
GLY A 493
 None
 0.87A 1rmtC-2p6rA:
undetectable		 1rmtC-2p6rA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 5 LYS A  53
PHE A  38
LEU A  45
LEU A  96
 None
 1.43A 1skxA-2p6rA:
undetectable		 1skxA-2p6rA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 7 LEU A 505
VAL A 616
VAL A 611
ILE A 607
 None
 0.89A 1t87B-2p6rA:
undetectable		 1t87B-2p6rA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		5 / 9 GLY A 509
ALA A 510
SER A 506
LEU A 505
LEU A 500
 None
 1.32A 1y7iA-2p6rA:
undetectable		 1y7iA-2p6rA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		5 / 8 LEU A  72
ILE A 118
GLU A 106
LEU A 128
ILE A 129
 None
 1.32A 2azxA-2p6rA:
undetectable		 2azxA-2p6rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		5 / 11 LEU A 128
ILE A 129
VAL A 139
LEU A  72
SER A 101
 None
 1.23A 2bxeA-2p6rA:
undetectable		 2bxeA-2p6rA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		3 / 3 TRP A  91
ALA A  60
VAL A  62
 None
 0.83A 2izqA-2p6rA:
undetectable
2izqB-2p6rA:
undetectable		 2izqA-2p6rA:
2.21
2izqB-2p6rA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 6 LEU A 634
LEU A 631
ILE A 653
ARG A 654
 None
 1.13A 2rlfB-2p6rA:
undetectable
2rlfC-2p6rA:
undetectable		 2rlfB-2p6rA:
6.01
2rlfC-2p6rA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 5 SER A 288
LEU A 590
GLY A 588
CYH A 580
 None
 0.96A 3aiaA-2p6rA:
2.7
3aiaB-2p6rA:
2.7		 3aiaA-2p6rA:
15.67
3aiaB-2p6rA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 295
GLY A 298
ALA A 299
SER A 263
LEU A 262
 None
 1.02A 3hs6A-2p6rA:
undetectable		 3hs6A-2p6rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 4 PRO A 476
THR A 477
GLY A 493
THR A 492
 None
 0.97A 3ib1A-2p6rA:
undetectable		 3ib1A-2p6rA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 618
ASP A 507
GLY A 626
ARG A 636
ILE A 571
 None
 1.28A 3k13A-2p6rA:
undetectable		 3k13A-2p6rA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		3 / 3 ALA A  60
VAL A  62
TRP A  91
 None
 0.78A 3l8lA-2p6rA:
undetectable
3l8lB-2p6rA:
undetectable		 3l8lA-2p6rA:
2.21
3l8lB-2p6rA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		3 / 3 ALA A  60
VAL A  62
TRP A  91
 None
 0.83A 3l8lC-2p6rA:
undetectable
3l8lD-2p6rA:
undetectable		 3l8lC-2p6rA:
2.21
3l8lD-2p6rA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 8 ASN A 602
GLU A 609
GLU A 610
LEU A 486
 None
 0.95A 3rqwC-2p6rA:
undetectable
3rqwD-2p6rA:
undetectable		 3rqwC-2p6rA:
19.01
3rqwD-2p6rA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 609
GLU A 610
LEU A 486
ASN A 602
 None
 0.95A 3rqwF-2p6rA:
2.0
3rqwJ-2p6rA:
undetectable		 3rqwF-2p6rA:
19.01
3rqwJ-2p6rA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 8 ILE A 514
LEU A 511
ILE A 593
GLY A 626
 None
 0.82A 4hb6A-2p6rA:
undetectable		 4hb6A-2p6rA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 8 ILE A 514
LEU A 511
ILE A 593
GLY A 626
 None
 0.83A 4hb8A-2p6rA:
undetectable		 4hb8A-2p6rA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		3 / 3 GLY A 410
GLU A 412
THR A 413
 None
 0.59A 4kouA-2p6rA:
undetectable		 4kouA-2p6rA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 5 VAL A 459
LEU A 434
ILE A 423
LEU A 420
 None
 0.82A 4mghA-2p6rA:
undetectable		 4mghA-2p6rA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 8 SER A 544
HIS A 512
ILE A 495
GLU A 560
 None
 1.28A 4ms4A-2p6rA:
2.9		 4ms4A-2p6rA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 8 LEU A 505
LEU A 500
VAL A 499
ILE A 495
 None
 0.87A 4oj4A-2p6rA:
undetectable		 4oj4A-2p6rA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		5 / 12 ASN A 283
ASP A 316
ILE A 279
SER A 288
ARG A 312
 None
 1.34A 4uroA-2p6rA:
undetectable		 4uroA-2p6rA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 5 ALA A 267
ARG A 296
ALA A 299
GLU A 293
 None
 1.38A 5a06C-2p6rA:
undetectable
5a06D-2p6rA:
undetectable		 5a06C-2p6rA:
19.74
5a06D-2p6rA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 4 ALA A 333
PRO A  76
LEU A 150
HIS A 148
 None
 1.19A 5eskA-2p6rA:
1.4		 5eskA-2p6rA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		4 / 5 ILE A 637
LEU A 669
LYS A 665
HIS A 662
 None
 1.16A 5jmnB-2p6rA:
undetectable		 5jmnB-2p6rA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  45
VAL A 163
THR A 164
ALA A 189
LEU A 192
 None
 0.82A 5kpcA-2p6rA:
3.5		 5kpcA-2p6rA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 340
PRO A  48
TYR A 363
ALA A 370
GLY A 371
 None
 1.27A 5tzoA-2p6rA:
undetectable		 5tzoA-2p6rA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 340
PRO A  48
TYR A 363
ALA A 370
GLY A 371
 None
 1.25A 5tzoC-2p6rA:
undetectable		 5tzoC-2p6rA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2p6r AFUHEL308 HELICASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 291
GLU A 315
VAL A 314
GLU A 282
ARG A 312
 None
 1.40A 5xipD-2p6rA:
undetectable		 5xipD-2p6rA:
21.70