SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2p6t TRANSCRIPTIONAL
REGULATOR, LRP/ASNC
FAMILY
(Neisseria
meningitidis) 		4 / 8 THR A 115
ASP A 116
PHE A 120
ASN A 118
 None
 1.05A 1lhvA-2p6tA:
undetectable		 1lhvA-2p6tA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 2p6t TRANSCRIPTIONAL
REGULATOR, LRP/ASNC
FAMILY
(Neisseria
meningitidis) 		3 / 3 ALA A  88
VAL A  90
TRP A  93
 None
 0.87A 1nt5A-2p6tA:
undetectable		 1nt5A-2p6tA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 2p6t TRANSCRIPTIONAL
REGULATOR, LRP/ASNC
FAMILY
(Neisseria
meningitidis) 		3 / 3 ALA A  88
VAL A  90
TRP A  93
 None
 0.87A 1nt5B-2p6tA:
undetectable		 1nt5B-2p6tA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2p6t TRANSCRIPTIONAL
REGULATOR, LRP/ASNC
FAMILY
(Neisseria
meningitidis) 		5 / 10 THR A 106
PHE A  86
LEU A 128
VAL A 124
PHE A 120
 None
 1.48A 1q23E-2p6tA:
undetectable		 1q23E-2p6tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2p6t TRANSCRIPTIONAL
REGULATOR, LRP/ASNC
FAMILY
(Neisseria
meningitidis) 		5 / 11 THR A 106
PHE A  86
LEU A 128
VAL A 124
PHE A 120
 None
 1.36A 1q23G-2p6tA:
undetectable		 1q23G-2p6tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2p6t TRANSCRIPTIONAL
REGULATOR, LRP/ASNC
FAMILY
(Neisseria
meningitidis) 		5 / 10 ILE A  72
ALA A  70
ALA A 112
GLN A  69
VAL A 134
 None
 1.11A 3falA-2p6tA:
undetectable		 3falA-2p6tA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2p6t TRANSCRIPTIONAL
REGULATOR, LRP/ASNC
FAMILY
(Neisseria
meningitidis) 		5 / 12 ILE A  76
ALA A 101
PHE A  86
ILE A  72
LEU A 128
 None
LEU  A1160 ( 4.7A)
None
None
None
 1.19A 4rgcA-2p6tA:
undetectable		 4rgcA-2p6tA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2p6t TRANSCRIPTIONAL
REGULATOR, LRP/ASNC
FAMILY
(Neisseria
meningitidis) 		4 / 8 ASP A  10
ILE A  13
ARG A  42
ASN A  25
 None
 1.25A 6hisA-2p6tA:
undetectable
6hisB-2p6tA:
undetectable		 6hisA-2p6tA:
22.73
6hisB-2p6tA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2p6t TRANSCRIPTIONAL
REGULATOR, LRP/ASNC
FAMILY
(Neisseria
meningitidis) 		4 / 8 ASP A  10
ILE A  13
ARG A  42
ASN A  25
 None
 1.25A 6hisB-2p6tA:
undetectable
6hisC-2p6tA:
undetectable		 6hisB-2p6tA:
22.73
6hisC-2p6tA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2p6t TRANSCRIPTIONAL
REGULATOR, LRP/ASNC
FAMILY
(Neisseria
meningitidis) 		4 / 8 ASP A  10
ILE A  13
ARG A  42
ASN A  25
 None
 1.23A 6hisC-2p6tA:
undetectable
6hisD-2p6tA:
undetectable		 6hisC-2p6tA:
22.73
6hisD-2p6tA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2p6t TRANSCRIPTIONAL
REGULATOR, LRP/ASNC
FAMILY
(Neisseria
meningitidis) 		4 / 8 ASN A  25
ASP A  10
ILE A  13
ARG A  42
 None
 1.23A 6hisA-2p6tA:
undetectable
6hisE-2p6tA:
undetectable		 6hisA-2p6tA:
22.73
6hisE-2p6tA:
22.73