SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p76'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		5 / 10 PHE A 237
ARG A 241
GLY A 253
GLY A 251
ALA A 249
 None
 1.01A 2ej3B-2p76A:
undetectable		 2ej3B-2p76A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		3 / 3 GLU A 169
HIS A  59
GLU A  87
 NA  A 401 ( 3.0A)
GOL  A 501 (-3.8A)
NA  A 401 ( 3.1A)
 0.53A 2x45B-2p76A:
undetectable		 2x45B-2p76A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		3 / 3 GLU A 169
HIS A  59
GLU A  87
 NA  A 401 ( 3.0A)
GOL  A 501 (-3.8A)
NA  A 401 ( 3.1A)
 0.57A 2x45C-2p76A:
undetectable		 2x45C-2p76A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		4 / 8 PHE A 297
GLY A 295
VAL A 293
LEU A 288
 GOL  A 501 (-4.2A)
None
None
None
 1.11A 3bgdB-2p76A:
undetectable		 3bgdB-2p76A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		3 / 3 SER A 172
ASP A 174
ASP A 210
 None
 0.88A 3iv6A-2p76A:
undetectable		 3iv6A-2p76A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		4 / 4 ASP A 255
ASP A 258
GLY A 253
THR A 264
 None
 1.22A 3tl9B-2p76A:
undetectable		 3tl9B-2p76A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		4 / 7 LEU A 228
LYS A 171
TYR A 167
LEU A 213
 GOL  A 501 ( 4.3A)
None
None
None
 1.13A 4b3qA-2p76A:
undetectable		 4b3qA-2p76A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GCP_A_AICA401_1
(OUTER MEMBRANE
PROTEIN F)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		5 / 9 TYR A  65
GLY A  64
PHE A 300
ASP A 302
SER A  84
 None
 1.18A 4gcpA-2p76A:
0.0		 4gcpA-2p76A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GCP_B_AICB401_1
(OUTER MEMBRANE
PROTEIN F)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		5 / 9 TYR A  65
GLY A  64
PHE A 300
ASP A 302
SER A  84
 None
 1.19A 4gcpB-2p76A:
0.0		 4gcpB-2p76A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		4 / 7 TYR A 166
ILE A 156
LEU A  90
TYR A 176
 None
 0.89A 4iqqA-2p76A:
undetectable		 4iqqA-2p76A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		4 / 8 TYR A 166
ILE A 156
LEU A  90
TYR A 176
 None
 0.80A 4iqqD-2p76A:
undetectable		 4iqqD-2p76A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		3 / 3 ARG A  60
HIS A  69
SER A  63
 None
 0.47A 4mjwA-2p76A:
undetectable
4mjwB-2p76A:
undetectable		 4mjwA-2p76A:
19.21
4mjwB-2p76A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		3 / 3 SER A  63
ARG A  60
HIS A  69
 None
 0.46A 4mjwA-2p76A:
undetectable
4mjwB-2p76A:
undetectable		 4mjwA-2p76A:
19.21
4mjwB-2p76A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		4 / 5 TYR A 167
LEU A 153
GLU A 169
VAL A 175
 None
None
NA  A 401 ( 3.0A)
None
 1.21A 4nkvA-2p76A:
undetectable		 4nkvA-2p76A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		4 / 5 TYR A 167
LEU A 183
GLU A 169
VAL A 175
 None
None
NA  A 401 ( 3.0A)
None
 1.30A 4nkvA-2p76A:
undetectable		 4nkvA-2p76A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		3 / 3 GLU A  68
THR A 278
HIS A  59
 None
None
GOL  A 501 (-3.8A)
 0.82A 4q15A-2p76A:
undetectable		 4q15A-2p76A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		3 / 3 GLU A  68
THR A 278
HIS A  59
 None
None
GOL  A 501 (-3.8A)
 0.82A 4q15B-2p76A:
undetectable		 4q15B-2p76A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		3 / 3 GLU A  68
THR A 278
HIS A  59
 None
None
GOL  A 501 (-3.8A)
 0.75A 4ydqB-2p76A:
undetectable		 4ydqB-2p76A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		5 / 12 TYR A  74
GLY A  61
HIS A  59
SER A  63
TYR A 145
 None
None
GOL  A 501 (-3.8A)
None
None
 1.17A 5n0oA-2p76A:
undetectable		 5n0oA-2p76A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		4 / 8 TYR A 166
ILE A 156
LEU A  90
TYR A 176
 None
 0.84A 5nooD-2p76A:
undetectable		 5nooD-2p76A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Staphylococcus
aureus) 		4 / 6 LEU A 213
TYR A 277
ASP A  89
GLU A 169
 None
GOL  A 501 ( 4.2A)
NA  A 401 (-2.6A)
NA  A 401 ( 3.0A)
 1.13A 6djzC-2p76A:
undetectable		 6djzC-2p76A:
20.72