SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p7v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 2p7v RNA POLYMERASE SIGMA
FACTOR RPOD
(Escherichia
coli) 		5 / 9 LEU B 573
LEU B 559
ILE B 590
VAL B 582
PHE B 580
 None
 1.24A 1gx8A-2p7vB:
undetectable		 1gx8A-2p7vB:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2p7v REGULATOR OF SIGMA D
(Escherichia
coli) 		3 / 3 ARG A 137
VAL A  25
TRP A  22
 None
 0.91A 1qw6A-2p7vA:
undetectable		 1qw6A-2p7vA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2p7v REGULATOR OF SIGMA D
(Escherichia
coli) 		3 / 3 ARG A 137
VAL A  25
TRP A  22
 None
 0.79A 1qwcA-2p7vA:
undetectable		 1qwcA-2p7vA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2p7v REGULATOR OF SIGMA D
(Escherichia
coli) 		3 / 3 ARG A 137
VAL A  25
TRP A  22
 None
 0.86A 1vagA-2p7vA:
undetectable		 1vagA-2p7vA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 2p7v REGULATOR OF SIGMA D
(Escherichia
coli) 		4 / 4 LEU A  61
SER A  60
TYR A  64
LEU A  65
 None
 1.32A 1xz3A-2p7vA:
3.2		 1xz3A-2p7vA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2p7v REGULATOR OF SIGMA D
(Escherichia
coli) 		3 / 3 ARG A 137
VAL A  25
TRP A  22
 None
 0.89A 1zviA-2p7vA:
2.0		 1zviA-2p7vA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 2p7v REGULATOR OF SIGMA D
(Escherichia
coli) 		4 / 7 LEU A  61
ALA A 133
GLY A 131
PHE A  57
 None
 0.94A 2wq5A-2p7vA:
undetectable		 2wq5A-2p7vA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 2p7v REGULATOR OF SIGMA D
(Escherichia
coli) 		4 / 7 TYR A  34
TYR A  33
PHE A 123
TYR A 120
 None
 1.35A 3ku9B-2p7vA:
undetectable		 3ku9B-2p7vA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 2p7v REGULATOR OF SIGMA D
(Escherichia
coli) 		5 / 10 ILE A 103
SER A  60
TYR A  33
ILE A 130
ALA A 133
 None
 1.22A 3u6tA-2p7vA:
undetectable		 3u6tA-2p7vA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2p7v REGULATOR OF SIGMA D
(Escherichia
coli) 		3 / 3 ARG A 137
VAL A  25
TRP A  22
 None
 0.73A 5fvoA-2p7vA:
undetectable		 5fvoA-2p7vA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2p7v REGULATOR OF SIGMA D
(Escherichia
coli) 		3 / 3 ARG A  75
ILE A  72
SER A  71
 None
 0.84A 5zw2A-2p7vA:
undetectable		 5zw2A-2p7vA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 2p7v RNA POLYMERASE SIGMA
FACTOR RPOD
(Escherichia
coli) 		4 / 6 GLU B 555
GLU B 591
ALA B 594
LYS B 593
 None
 0.95A 6an0A-2p7vB:
undetectable		 6an0A-2p7vB:
9.86