SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p82'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		5 / 11 LEU A  79
TYR A  57
PRO A 261
TRP A  75
PRO A 148
 None
 1.46A 1klmA-2p82A:
undetectable		 1klmA-2p82A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		3 / 3 ASP A  98
ASP A  48
LYS A 103
 None
 0.95A 1lqtB-2p82A:
undetectable		 1lqtB-2p82A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		3 / 3 ASP A  98
ASP A  48
LYS A 103
 None
 0.93A 1lquB-2p82A:
undetectable		 1lquB-2p82A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		4 / 4 VAL A 318
ALA A 256
LEU A 275
PHE A 267
 None
 0.77A 1q97B-2p82A:
undetectable		 1q97B-2p82A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		4 / 6 VAL A 177
THR A 176
LEU A 351
ARG A 347
 None
 0.94A 1s8fB-2p82A:
undetectable		 1s8fB-2p82A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		4 / 6 GLN A  83
PHE A  55
ILE A 128
PHE A 300
 None
 1.19A 4fgkA-2p82A:
undetectable		 4fgkA-2p82A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		4 / 6 ALA A 319
GLY A 147
ILE A 226
VAL A 154
 None
 0.79A 4r21A-2p82A:
undetectable		 4r21A-2p82A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		4 / 7 HIS A 281
PRO A 280
ASP A 279
PHE A 277
 None
 1.31A 5a1iA-2p82A:
undetectable		 5a1iA-2p82A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		4 / 4 CYH A 247
PHE A 244
ILE A 226
GLY A 255
 None
 1.37A 5hesB-2p82A:
0.1		 5hesB-2p82A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		3 / 3 CYH A 124
LYS A 122
HIS A 129
 None
 0.99A 5js5A-2p82A:
undetectable		 5js5A-2p82A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		4 / 5 ALA A 256
VAL A 318
PHE A 248
ILE A 236
 None
 0.93A 5of1A-2p82A:
undetectable		 5of1A-2p82A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		4 / 5 ALA A 256
VAL A 318
PHE A 248
ILE A 236
 None
 1.05A 5of1B-2p82A:
undetectable		 5of1B-2p82A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		3 / 3 SER A  43
LYS A  44
SER A  47
 None
 0.67A 6az3P-2p82A:
undetectable		 6az3P-2p82A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		3 / 3 ILE A  91
ASN A 165
CYH A 125
 None
 0.88A 6bp4A-2p82A:
undetectable		 6bp4A-2p82A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		4 / 5 THR A 299
ARG A  58
THR A 294
GLN A 112
 None
 1.10A 6ectA-2p82A:
undetectable		 6ectA-2p82A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		4 / 5 THR A 299
ARG A  58
THR A 294
GLN A 112
 None
 1.21A 6ecxA-2p82A:
undetectable		 6ecxA-2p82A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens) 		4 / 7 HIS A 281
PRO A 280
ASP A 279
PHE A 277
 None
 1.31A 6g6rA-2p82A:
undetectable		 6g6rA-2p82A:
21.50