SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p87'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 6 LEU A2156
TRP A2199
PHE A2120
VAL A2141
 None
 1.12A 1ibgH-2p87A:
undetectable		 1ibgH-2p87A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 8 ASP A2185
LEU A2181
HIS A2172
SER A2210
 None
 1.10A 2q0iA-2p87A:
undetectable		 2q0iA-2p87A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 7 PRO A2267
VAL A2289
SER A2268
PRO A2142
 None
 0.99A 2v2gA-2p87A:
undetectable
2v2gB-2p87A:
undetectable		 2v2gA-2p87A:
18.06
2v2gB-2p87A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 7 PRO A2142
PRO A2267
VAL A2289
SER A2268
 None
 1.02A 2v2gA-2p87A:
undetectable
2v2gB-2p87A:
undetectable		 2v2gA-2p87A:
18.06
2v2gB-2p87A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 7 PRO A2267
VAL A2289
SER A2268
PRO A2142
 None
 0.99A 2v2gC-2p87A:
undetectable
2v2gD-2p87A:
undetectable		 2v2gC-2p87A:
18.06
2v2gD-2p87A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 7 PRO A2142
PRO A2267
VAL A2289
SER A2268
 None
 1.04A 2v2gC-2p87A:
undetectable
2v2gD-2p87A:
undetectable		 2v2gC-2p87A:
18.06
2v2gD-2p87A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 8 PRO A2267
VAL A2289
SER A2268
PRO A2142
 None
 0.97A 2v32A-2p87A:
undetectable
2v32B-2p87A:
undetectable		 2v32A-2p87A:
18.06
2v32B-2p87A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 8 PRO A2142
PRO A2267
VAL A2289
SER A2268
 None
 1.00A 2v32A-2p87A:
undetectable
2v32B-2p87A:
undetectable		 2v32A-2p87A:
18.06
2v32B-2p87A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 8 PRO A2267
VAL A2289
SER A2268
PRO A2142
 None
 1.00A 2v32C-2p87A:
undetectable
2v32D-2p87A:
undetectable		 2v32C-2p87A:
18.06
2v32D-2p87A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		5 / 8 VAL A2141
PRO A2142
PRO A2267
VAL A2289
SER A2268
 None
 1.15A 2v32C-2p87A:
undetectable
2v32D-2p87A:
undetectable		 2v32C-2p87A:
18.06
2v32D-2p87A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 8 PRO A2267
VAL A2289
SER A2268
PRO A2142
 None
 0.95A 2v41C-2p87A:
undetectable
2v41D-2p87A:
undetectable		 2v41C-2p87A:
18.06
2v41D-2p87A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 7 PRO A2267
VAL A2289
SER A2268
PRO A2142
 None
 0.93A 2v41E-2p87A:
undetectable
2v41F-2p87A:
undetectable		 2v41E-2p87A:
18.06
2v41F-2p87A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 7 PRO A2142
PRO A2267
VAL A2289
SER A2268
 None
 0.98A 2v41E-2p87A:
undetectable
2v41F-2p87A:
undetectable		 2v41E-2p87A:
18.06
2v41F-2p87A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 8 PRO A2142
PRO A2267
VAL A2289
SER A2268
 None
 0.95A 2v41G-2p87A:
undetectable
2v41H-2p87A:
undetectable		 2v41G-2p87A:
18.06
2v41H-2p87A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		3 / 3 PHE A2107
CYH A2209
PHE A2211
 None
 0.99A 3cr5X-2p87A:
undetectable		 3cr5X-2p87A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		3 / 3 ASN A2275
HIS A2302
VAL A2271
 None
 0.88A 3elzB-2p87A:
undetectable		 3elzB-2p87A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		5 / 12 ALA A2220
LEU A2181
PRO A2225
SER A2226
THR A2219
 None
 1.12A 3nrrB-2p87A:
undetectable		 3nrrB-2p87A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 7 HIS A2299
ASP A2301
HIS A2302
VAL A2266
 None
 1.04A 4hvrA-2p87A:
undetectable		 4hvrA-2p87A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 6 ASP A2185
TYR A2221
HIS A2172
THR A2173
 None
 1.39A 4paeA-2p87A:
undetectable		 4paeA-2p87A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA613_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 4 ASP A2200
LYS A2203
THR A2204
PRO A2167
 None
 1.39A 5jwaA-2p87A:
0.0		 5jwaA-2p87A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 2p87 PRE-MRNA-SPLICING
FACTOR PRP8
(Caenorhabditis
elegans) 		4 / 7 GLY A2231
SER A2226
GLY A2227
VAL A2186
 None
 0.94A 6ekzA-2p87A:
undetectable		 6ekzA-2p87A:
16.60