SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p88'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		4 / 4 VAL A 319
ALA A 310
LEU A 343
PHE A 311
 None
 0.94A 1q97B-2p88A:
undetectable		 1q97B-2p88A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		4 / 8 GLU A 218
THR A 322
ILE A  21
TYR A  23
 MG  A 501 (-3.1A)
None
None
None
 1.13A 1qvtA-2p88A:
undetectable		 1qvtA-2p88A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		5 / 8 GLY A  48
GLY A  46
ALA A 102
LEU A 349
ILE A 274
 None
 1.09A 1yajC-2p88A:
undetectable		 1yajC-2p88A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		5 / 10 ILE A 175
ALA A 177
ASN A 213
ALA A 146
ILE A 217
 None
 1.13A 2aclC-2p88A:
undetectable		 2aclC-2p88A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		5 / 12 ASN A 333
ILE A  33
LEU A 361
ALA A 302
ASP A 356
 None
 1.30A 2iyfB-2p88A:
undetectable		 2iyfB-2p88A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		5 / 12 MET A 229
PRO A 220
ALA A 277
LEU A 280
ALA A 281
 None
 1.11A 2jjpA-2p88A:
undetectable		 2jjpA-2p88A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		5 / 9 GLY A  48
THR A  98
ALA A  99
LEU A  70
THR A  65
 None
 1.06A 2npnA-2p88A:
undetectable		 2npnA-2p88A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		5 / 12 LEU A 122
ILE A 103
LEU A  66
ILE A  32
VAL A 301
 None
 1.08A 2ygnA-2p88A:
undetectable		 2ygnA-2p88A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		3 / 3 SER A  31
GLY A  48
SER A 299
 None
 0.66A 3loqA-2p88A:
3.7		 3loqA-2p88A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		3 / 3 VAL A 136
VAL A 297
SER A 295
 None
 0.75A 3n8xB-2p88A:
undetectable		 3n8xB-2p88A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		5 / 12 GLY A  48
ALA A 302
SER A 295
ASP A  51
ALA A  50
 None
 1.19A 3nmuA-2p88A:
undetectable
3nmuF-2p88A:
3.7		 3nmuA-2p88A:
21.45
3nmuF-2p88A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		4 / 6 GLU A  37
LYS A  35
TYR A  45
ASP A 109
 None
 1.40A 3pocB-2p88A:
5.8		 3pocB-2p88A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		5 / 12 GLY A 294
GLY A 323
VAL A 133
ALA A 302
PHE A 327
 None
 1.26A 3qowA-2p88A:
undetectable		 3qowA-2p88A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		4 / 7 ILE A  85
LEU A  74
LEU A  66
HIS A  86
 None
 0.92A 3r9vA-2p88A:
undetectable
3r9vB-2p88A:
undetectable		 3r9vA-2p88A:
21.21
3r9vB-2p88A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		4 / 6 LEU A  13
PRO A 324
GLU A  47
SER A 300
 None
 1.37A 3vlnA-2p88A:
undetectable		 3vlnA-2p88A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		5 / 9 ASP A 109
ILE A 110
GLY A  44
THR A  38
GLY A  41
 None
 1.16A 4acaB-2p88A:
3.1
4acaC-2p88A:
3.4		 4acaB-2p88A:
21.59
4acaC-2p88A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		4 / 4 LEU A 268
ILE A 123
GLY A 273
PHE A 108
 None
 1.00A 4dc3A-2p88A:
undetectable		 4dc3A-2p88A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		5 / 12 PHE A 131
LEU A 321
GLY A 294
ASN A 265
ALA A 302
 None
 1.23A 4eb4B-2p88A:
undetectable		 4eb4B-2p88A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		4 / 7 LEU A 115
ILE A   3
THR A  38
MET A  36
 None
 1.28A 5ljcA-2p88A:
undetectable		 5ljcA-2p88A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		5 / 12 GLY A  24
GLN A 194
ASP A 224
VAL A  54
ASP A  52
 None
 1.44A 6bxlA-2p88A:
0.6		 6bxlA-2p88A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bacillus
cereus) 		3 / 3 TRP A 216
ILE A 214
ASP A 215
 None
 0.69A 6i0y7-2p88A:
undetectable		 6i0y7-2p88A:
6.52