SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		3 / 3 LYS A 243
ASP A 114
ASP A  60
 OCS  A 242 (-3.0A)
None
MG  A 306 (-2.5A)
 0.99A 2br4D-2p8eA:
undetectable		 2br4D-2p8eA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		4 / 7 ALA A 201
GLY A 203
VAL A  67
ASP A  60
 None
None
None
MG  A 306 (-2.5A)
 0.84A 2uyqA-2p8eA:
undetectable		 2uyqA-2p8eA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		5 / 12 GLY A  17
LEU A  22
LEU A  26
SER A  54
GLY A  45
 None
 0.95A 3g2oA-2p8eA:
undetectable		 3g2oA-2p8eA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		5 / 12 GLY A  17
LEU A  22
LEU A  26
SER A  54
GLY A  45
 None
 0.82A 3g2oB-2p8eA:
undetectable		 3g2oB-2p8eA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		5 / 10 TRP A 274
THR A 278
ILE A 245
ILE A 290
SER A  27
 None
None
OCS  A 242 ( 4.1A)
None
None
 1.41A 3kpbD-2p8eA:
undetectable		 3kpbD-2p8eA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		5 / 12 SER A 130
ASP A 204
ASP A 128
MET A 117
ILE A 113
 None
 1.28A 3lpsA-2p8eA:
undetectable		 3lpsA-2p8eA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		4 / 5 ARG A  33
ASP A  60
ASP A 243
ASP A 151
 None
MG  A 306 (-2.5A)
MG  A 306 (-2.9A)
None
 1.27A 3naiA-2p8eA:
undetectable		 3naiA-2p8eA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		4 / 5 ARG A  33
ASP A  60
ASP A 243
ASP A 151
 None
MG  A 306 (-2.5A)
MG  A 306 (-2.9A)
None
 1.18A 3naiC-2p8eA:
undetectable		 3naiC-2p8eA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		5 / 12 PHE A 110
GLY A 136
ILE A 106
VAL A 226
PHE A  55
 None
 1.17A 4a6dA-2p8eA:
undetectable		 4a6dA-2p8eA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		4 / 5 HIS A 169
SER A 199
SER A 221
VAL A 220
 None
 1.36A 4a99D-2p8eA:
undetectable		 4a99D-2p8eA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		4 / 7 TYR A  70
HIS A  74
ILE A 113
TYR A 116
 None
 1.14A 4g5jA-2p8eA:
undetectable		 4g5jA-2p8eA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		5 / 10 VAL A  58
TYR A  59
GLY A 150
GLY A 136
ASP A  38
 None
None
None
None
OCS  A 242 ( 2.7A)
 1.43A 4mmcA-2p8eA:
undetectable		 4mmcA-2p8eA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		5 / 11 SER A 130
ASP A 204
ASP A 128
MET A 117
ILE A 113
 None
 1.38A 4urnB-2p8eA:
undetectable		 4urnB-2p8eA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		5 / 11 SER A 130
ASP A 204
ASP A 128
MET A 117
ILE A 113
 None
 1.41A 4urnC-2p8eA:
undetectable		 4urnC-2p8eA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		5 / 11 ASN A 148
SER A 199
GLU A 176
GLU A 225
THR A 133
 None
 1.35A 4xt7A-2p8eA:
undetectable		 4xt7A-2p8eA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		3 / 3 LEU A 268
LEU A 262
ARG A 153
 None
 0.63A 5hnzB-2p8eA:
undetectable		 5hnzB-2p8eA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens) 		4 / 7 ASP A 128
GLY A  61
SER A 130
GLY A 131
 None
 0.85A 6ekzA-2p8eA:
undetectable		 6ekzA-2p8eA:
15.38