SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A  30
ILE A  53
ASP A  78
ARG A  80
GLY A  96
 GOL  A 213 ( 3.7A)
GOL  A 213 (-4.0A)
None
None
None
 0.63A 2qe6A-2p8jA:
14.4		 2qe6A-2p8jA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A  30
GLY A  32
ILE A  53
ASP A  78
ARG A  80
 GOL  A 213 ( 3.7A)
None
GOL  A 213 (-4.0A)
None
None
 0.81A 2qe6B-2p8jA:
14.4		 2qe6B-2p8jA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A  30
ILE A  53
ASP A  78
ARG A  80
GLY A  96
 GOL  A 213 ( 3.7A)
GOL  A 213 (-4.0A)
None
None
None
 0.57A 2qe6B-2p8jA:
14.4		 2qe6B-2p8jA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 6 GLY A  30
ILE A  51
GLU A  52
ILE A  53
 GOL  A 213 ( 3.7A)
None
GOL  A 213 (-3.6A)
GOL  A 213 (-4.0A)
 0.50A 3a7eA-2p8jA:
11.6		 3a7eA-2p8jA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 11 GLY A  30
GLY A  32
ILE A  51
GLU A  52
ASP A  78
 GOL  A 213 ( 3.7A)
None
None
GOL  A 213 (-3.6A)
None
 0.75A 3dxyA-2p8jA:
5.4		 3dxyA-2p8jA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		3 / 3 MET A  89
CYH A  29
PRO A  83
 None
 0.79A 3h52C-2p8jA:
undetectable		 3h52C-2p8jA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 7 PHE A 169
GLU A 164
VAL A 160
VAL A 196
 None
 1.32A 3jx6A-2p8jA:
undetectable
3jx6B-2p8jA:
2.6		 3jx6A-2p8jA:
21.95
3jx6B-2p8jA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A  30
ILE A  51
GLN A  57
ILE A  79
HIS A 100
 GOL  A 213 ( 3.7A)
None
None
GOL  A 213 ( 4.6A)
None
 0.99A 4ax8A-2p8jA:
14.9		 4ax8A-2p8jA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		3 / 3 GLN A 148
ASP A 132
GLN A 193
 None
 0.89A 4aztA-2p8jA:
13.2		 4aztA-2p8jA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A  30
GLY A  32
ILE A  53
ASP A  78
ILE A  79
 GOL  A 213 ( 3.7A)
None
GOL  A 213 (-4.0A)
None
GOL  A 213 ( 4.6A)
 0.88A 4iv0B-2p8jA:
16.1		 4iv0B-2p8jA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 9 ASP A  55
ALA A  61
GLY A  77
SER A  54
GLY A  32
 None
 1.33A 4mmbA-2p8jA:
undetectable		 4mmbA-2p8jA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 9 ILE A 113
THR A  97
ASP A  28
ILE A  79
 None
GOL  A 213 ( 4.0A)
None
GOL  A 213 ( 4.6A)
 1.04A 5lg3I-2p8jA:
undetectable		 5lg3I-2p8jA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ILE A  74
GLY A  50
VAL A  26
VAL A  92
ALA A  61
 GOL  A 212 (-3.8A)
None
None
None
None
 1.07A 5n0oA-2p8jA:
undetectable		 5n0oA-2p8jA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ILE A  74
GLY A  50
VAL A  26
VAL A  92
ALA A  61
 GOL  A 212 (-3.8A)
None
None
None
None
 1.05A 5n0rA-2p8jA:
undetectable		 5n0rA-2p8jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ILE A  74
GLY A  50
VAL A  26
VAL A  92
ALA A  61
 GOL  A 212 (-3.8A)
None
None
None
None
 1.07A 5n0tA-2p8jA:
undetectable		 5n0tA-2p8jA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ILE A  74
GLY A  50
VAL A  26
VAL A  92
ALA A  61
 GOL  A 212 (-3.8A)
None
None
None
None
 1.07A 5n0wA-2p8jA:
undetectable		 5n0wA-2p8jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ILE A  74
GLY A  50
VAL A  26
VAL A  92
ALA A  61
 GOL  A 212 (-3.8A)
None
None
None
None
 1.08A 5n0wB-2p8jA:
undetectable		 5n0wB-2p8jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ILE A  74
GLY A  50
VAL A  26
VAL A  92
ALA A  61
 GOL  A 212 (-3.8A)
None
None
None
None
 1.06A 5n4iA-2p8jA:
undetectable		 5n4iA-2p8jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		6 / 12 ILE A 125
ALA A 200
ALA A 123
LEU A 117
ILE A  79
CYH A  29
 None
None
None
None
GOL  A 213 ( 4.6A)
None
 1.35A 6a60D-2p8jA:
undetectable		 6a60D-2p8jA:
13.55