SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2p8t HYPOTHETICAL PROTEIN
PH0730
(Pyrococcus
horikoshii) 		4 / 6 PHE A 120
THR A  16
VAL A  17
LEU A  21
 None
 1.02A 2e1qA-2p8tA:
undetectable		 2e1qA-2p8tA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2p8t HYPOTHETICAL PROTEIN
PH0730
(Pyrococcus
horikoshii) 		4 / 6 PHE A 120
THR A  16
VAL A  17
LEU A  21
 None
 0.97A 2e1qC-2p8tA:
2.3		 2e1qC-2p8tA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 2p8t HYPOTHETICAL PROTEIN
PH0730
(Pyrococcus
horikoshii) 		4 / 5 VAL A 101
TYR A 158
VAL A 130
ASP A 160
 None
 1.34A 2x45A-2p8tA:
undetectable		 2x45A-2p8tA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 2p8t HYPOTHETICAL PROTEIN
PH0730
(Pyrococcus
horikoshii) 		4 / 5 VAL A 101
TYR A 158
VAL A 130
ASP A 160
 None
 1.26A 2x45C-2p8tA:
undetectable		 2x45C-2p8tA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 2p8t HYPOTHETICAL PROTEIN
PH0730
(Pyrococcus
horikoshii) 		4 / 8 PRO A 172
ILE A  98
SER A  91
GLY A  89
 None
 0.94A 3lslA-2p8tA:
undetectable
3lslD-2p8tA:
undetectable		 3lslA-2p8tA:
24.90
3lslD-2p8tA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2p8t HYPOTHETICAL PROTEIN
PH0730
(Pyrococcus
horikoshii) 		4 / 7 PHE A 120
THR A  16
VAL A  17
LEU A  21
 None
 1.01A 3uniA-2p8tA:
undetectable		 3uniA-2p8tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 2p8t HYPOTHETICAL PROTEIN
PH0730
(Pyrococcus
horikoshii) 		5 / 12 LEU A  50
LEU A  27
GLY A  32
SER A  37
LEU A  40
 None
 1.14A 4zbrA-2p8tA:
undetectable		 4zbrA-2p8tA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_A_ASCA502_0
(OS09G0567300 PROTEIN)		 2p8t HYPOTHETICAL PROTEIN
PH0730
(Pyrococcus
horikoshii) 		4 / 5 GLU A  86
PRO A  87
ARG A  77
ARG A  39
 None
 1.22A 5jcnA-2p8tA:
undetectable		 5jcnA-2p8tA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 2p8t HYPOTHETICAL PROTEIN
PH0730
(Pyrococcus
horikoshii) 		4 / 6 GLU A  86
PRO A  87
ARG A  77
ARG A  39
 None
 1.24A 5jcnB-2p8tA:
undetectable		 5jcnB-2p8tA:
19.56