SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 11 LEU A 408
ALA A 354
MET A 344
GLN A 340
ARG A 415
 None
 1.35A 1iiuA-2p8uA:
undetectable		 1iiuA-2p8uA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ASP A 282
LEU A 275
LEU A 279
 None
 0.68A 1ikeA-2p8uA:
undetectable		 1ikeA-2p8uA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 408
ALA A 354
MET A 344
GLN A 340
ARG A 415
 None
 1.35A 1kt4A-2p8uA:
undetectable		 1kt4A-2p8uA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ALA A 185
LEU A 179
LEU A 386
LEU A 357
 None
 0.97A 1mt1D-2p8uA:
0.4
1mt1E-2p8uA:
undetectable		 1mt1D-2p8uA:
13.22
1mt1E-2p8uA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ASP A 282
LEU A 275
LEU A 279
 None
 0.70A 1np1B-2p8uA:
undetectable		 1np1B-2p8uA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 GLY A 132
TYR A 375
SER A 374
VAL A 156
ALA A 135
 None
None
SCY  A 129 ( 4.2A)
None
None
 1.38A 2avdA-2p8uA:
undetectable		 2avdA-2p8uA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 6 THR A 389
VAL A 388
LEU A 187
ALA A 397
 None
 1.04A 2e1qA-2p8uA:
undetectable		 2e1qA-2p8uA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 6 THR A 389
VAL A 388
LEU A 187
ALA A 397
 None
 0.97A 2e1qC-2p8uA:
undetectable		 2e1qC-2p8uA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 11 THR A 126
THR A 125
SER A 377
GLY A 376
ALA A 380
 None
None
SCY  A 129 ( 3.6A)
SCY  A 129 ( 3.5A)
None
 0.87A 2f162-2p8uA:
undetectable		 2f162-2p8uA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 11 THR A 126
THR A 125
SER A 377
GLY A 376
ALA A 380
 None
None
SCY  A 129 ( 3.6A)
SCY  A 129 ( 3.5A)
None
 0.87A 2f16N-2p8uA:
undetectable		 2f16N-2p8uA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		3 / 3 VAL A  73
VAL A 155
ASP A 119
 None
 0.55A 2fumD-2p8uA:
undetectable		 2fumD-2p8uA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 GLY A 371
SER A 334
MET A 278
LEU A 229
LEU A 226
 None
 1.09A 2hw2A-2p8uA:
undetectable		 2hw2A-2p8uA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		3 / 3 LEU A  82
TYR A 152
GLY A 150
 None
 0.57A 2ocuA-2p8uA:
undetectable		 2ocuA-2p8uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ALA A 134
GLY A 132
GLY A 131
GLY A 158
ASP A 159
 None
None
SCY  A 129 ( 4.9A)
None
None
 0.90A 2pkmA-2p8uA:
undetectable		 2pkmA-2p8uA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		3 / 3 LEU A 455
ASN A  66
ARG A 464
 None
 0.90A 2qhfA-2p8uA:
undetectable		 2qhfA-2p8uA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 7 TRP A 244
GLY A 371
MET A 261
GLY A 192
PHE A 253
 None
 1.30A 2qwxA-2p8uA:
undetectable
2qwxB-2p8uA:
undetectable		 2qwxA-2p8uA:
20.13
2qwxB-2p8uA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 8 PHE A 189
LEU A 179
VAL A 372
LEU A 386
 None
 0.88A 2zujA-2p8uA:
undetectable		 2zujA-2p8uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 THR A 126
THR A 125
SER A 377
GLY A 376
ALA A 380
 None
None
SCY  A 129 ( 3.6A)
SCY  A 129 ( 3.5A)
None
 0.85A 3mg02-2p8uA:
undetectable
3mg0V-2p8uA:
undetectable		 3mg02-2p8uA:
18.10
3mg0V-2p8uA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 11 THR A 126
THR A 125
SER A 377
GLY A 376
ALA A 380
 None
None
SCY  A 129 ( 3.6A)
SCY  A 129 ( 3.5A)
None
 0.86A 3mg0N-2p8uA:
undetectable		 3mg0N-2p8uA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 GLY A 131
ARG A 231
SER A 374
PHE A 373
ALA A 228
 SCY  A 129 ( 4.9A)
None
SCY  A 129 ( 4.2A)
None
None
 1.20A 3sueB-2p8uA:
undetectable		 3sueB-2p8uA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 5 ASN A 127
ALA A 128
TYR A 375
ALA A 381
 None
SCY  A 129 ( 2.9A)
None
None
 1.29A 3twpD-2p8uA:
undetectable		 3twpD-2p8uA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 9 GLY A 158
ALA A 176
GLY A 351
LEU A  76
VAL A  72
 None
 0.96A 3u7sB-2p8uA:
undetectable		 3u7sB-2p8uA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 7 THR A 389
VAL A 388
LEU A 187
ALA A 397
 None
 1.00A 3uniA-2p8uA:
undetectable		 3uniA-2p8uA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 PHE A 327
HIS A 264
LEU A 383
LEU A 255
MET A 278
 None
SCY  A 129 ( 3.7A)
None
None
None
 1.36A 3vn2A-2p8uA:
undetectable		 3vn2A-2p8uA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 6 VAL A 136
LEU A 179
ILE A  19
VAL A 349
 None
 0.93A 4a9kA-2p8uA:
undetectable		 4a9kA-2p8uA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 7 GLU A 121
ASN A 141
ILE A 143
TRP A 142
 None
 1.13A 4ii8A-2p8uA:
undetectable		 4ii8A-2p8uA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 8 VAL A 156
LEU A 108
ASP A  64
ILE A  65
 None
 0.86A 4lzrA-2p8uA:
undetectable		 4lzrA-2p8uA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A  68
VAL A 162
ARG A 430
GLY A  57
VAL A 337
 None
 1.00A 4y8wC-2p8uA:
undetectable		 4y8wC-2p8uA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 7 THR A 402
LEU A 357
LEU A 365
THR A 389
 None
 0.85A 4z90A-2p8uA:
undetectable
4z90B-2p8uA:
undetectable
4z90C-2p8uA:
undetectable
4z90D-2p8uA:
undetectable
4z90E-2p8uA:
undetectable		 4z90A-2p8uA:
20.87
4z90B-2p8uA:
20.87
4z90C-2p8uA:
20.87
4z90D-2p8uA:
20.87
4z90E-2p8uA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 7 GLY A 172
GLY A 342
SER A 338
PHE A  58
 None
 0.69A 5ergB-2p8uA:
undetectable		 5ergB-2p8uA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 THR A 126
THR A 125
SER A 377
GLY A 376
ALA A 380
 None
None
SCY  A 129 ( 3.6A)
SCY  A 129 ( 3.5A)
None
 0.83A 5l5zV-2p8uA:
undetectable
5l5zb-2p8uA:
undetectable		 5l5zV-2p8uA:
17.88
5l5zb-2p8uA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 THR A 126
THR A 125
SER A 377
GLY A 376
ALA A 380
 None
None
SCY  A 129 ( 3.6A)
SCY  A 129 ( 3.5A)
None
 0.83A 5l5zH-2p8uA:
undetectable
5l5zN-2p8uA:
undetectable		 5l5zH-2p8uA:
17.88
5l5zN-2p8uA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ILE A 181
GLY A 182
LEU A  22
LEU A 357
LEU A 187
 None
 0.98A 5nfjA-2p8uA:
undetectable		 5nfjA-2p8uA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 MET A  56
GLY A  57
SER A 347
TYR A 345
GLN A  53
 None
None
None
SCY  A 129 ( 4.2A)
None
 1.39A 5ttfC-2p8uA:
undetectable		 5ttfC-2p8uA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 MET A  56
GLY A  57
SER A 347
TYR A 345
GLN A  53
 None
None
None
SCY  A 129 ( 4.2A)
None
 1.41A 5v9iD-2p8uA:
undetectable		 5v9iD-2p8uA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 VAL A 337
ASP A  40
PHE A 423
PRO A  27
GLY A 175
 None
 1.24A 6gnfA-2p8uA:
undetectable		 6gnfA-2p8uA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 GLY A 173
GLY A 172
GLY A  93
HIS A 264
PRO A 214
 None
None
None
SCY  A 129 ( 3.7A)
None
 1.06A 6gngB-2p8uA:
undetectable		 6gngB-2p8uA:
22.81