SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p91'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aquifex
aeolicus) 		5 / 11 ALA A 180
LEU A 181
SER A 106
ILE A 107
ALA A 108
 None
 1.06A 1ha2A-2p91A:
undetectable		 1ha2A-2p91A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aquifex
aeolicus) 		5 / 11 LEU A 141
THR A 142
THR A  27
ILE A  26
ILE A 102
 None
 1.14A 1pkvA-2p91A:
undetectable
1pkvB-2p91A:
undetectable		 1pkvA-2p91A:
16.32
1pkvB-2p91A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aquifex
aeolicus) 		5 / 11 ILE A 102
LEU A 141
THR A 142
THR A  27
ILE A  26
 None
 1.16A 1pkvA-2p91A:
undetectable
1pkvB-2p91A:
undetectable		 1pkvA-2p91A:
16.32
1pkvB-2p91A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aquifex
aeolicus) 		5 / 12 GLU A  20
GLY A  47
ARG A  45
ALA A  48
ALA A  24
 None
 1.26A 2br4B-2p91A:
5.2		 2br4B-2p91A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aquifex
aeolicus) 		5 / 9 LEU A 100
LEU A 146
LEU A 148
LEU A 141
ILE A 103
 None
 0.90A 2f7aB-2p91A:
undetectable		 2f7aB-2p91A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aquifex
aeolicus) 		5 / 12 GLY A  28
ALA A 211
ALA A  55
PHE A  52
ILE A  35
 None
 1.09A 3jb1A-2p91A:
4.2		 3jb1A-2p91A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aquifex
aeolicus) 		3 / 3 ARG A 152
ASP A 250
ASP A 101
 None
 0.87A 3jb2A-2p91A:
3.6		 3jb2A-2p91A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aquifex
aeolicus) 		5 / 12 LEU A 159
THR A  27
ALA A  36
ILE A 237
ILE A  39
 None
 1.00A 3ut5B-2p91A:
7.2		 3ut5B-2p91A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aquifex
aeolicus) 		3 / 3 TYR A 136
ASP A  83
ASP A  79
 None
 0.87A 4a6eA-2p91A:
5.2		 4a6eA-2p91A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aquifex
aeolicus) 		4 / 6 VAL A 240
SER A 106
ALA A 212
PHE A 218
 None
 1.12A 4nedA-2p91A:
undetectable		 4nedA-2p91A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aquifex
aeolicus) 		5 / 12 LEU A 146
ARG A 143
ILE A 156
LEU A 188
ALA A 140
 None
 1.08A 4o1zB-2p91A:
undetectable		 4o1zB-2p91A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aquifex
aeolicus) 		5 / 12 GLU A  84
LEU A 148
LEU A 100
ARG A  23
ALA A  51
 None
 1.04A 4wcxC-2p91A:
2.3		 4wcxC-2p91A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aquifex
aeolicus) 		4 / 7 GLY A 241
VAL A 157
ILE A 102
VAL A 104
 None
 0.78A 5ik1A-2p91A:
undetectable		 5ik1A-2p91A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aquifex
aeolicus) 		5 / 12 LEU A 159
THR A  27
ALA A  36
ILE A 237
ILE A  39
 None
 0.90A 5itzB-2p91A:
7.4		 5itzB-2p91A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aquifex
aeolicus) 		5 / 12 LEU A 159
THR A  27
ALA A  36
ILE A 237
ILE A  39
 None
 0.91A 5xiwB-2p91A:
7.2		 5xiwB-2p91A:
13.68