SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p9n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		3 / 3 ALA C  76
VAL C  78
TRP C 104
 None
 0.75A 1av2C-2p9nC:
undetectable
1av2D-2p9nC:
undetectable		 1av2C-2p9nC:
3.52
1av2D-2p9nC:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		3 / 3 ALA C 249
VAL C 208
TRP C 219
 None
 0.75A 1gmkA-2p9nC:
undetectable
1gmkB-2p9nC:
undetectable		 1gmkA-2p9nC:
3.52
1gmkB-2p9nC:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		3 / 3 ALA C 249
VAL C 208
TRP C 219
 None
 0.76A 1gmkC-2p9nC:
undetectable
1gmkD-2p9nC:
undetectable		 1gmkC-2p9nC:
3.52
1gmkD-2p9nC:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		5 / 10 LEU C 335
SER C 336
THR C 347
THR C 251
SER C 333
 None
 1.48A 1rqpB-2p9nC:
undetectable		 1rqpB-2p9nC:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		5 / 12 GLY C 207
HIS C 206
ALA C 260
HIS C 222
ALA C 261
 None
 0.95A 1utdL-2p9nC:
undetectable
1utdM-2p9nC:
undetectable		 1utdL-2p9nC:
11.08
1utdM-2p9nC:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		3 / 3 ALA C  76
VAL C  78
TRP C 104
 None
 0.68A 1w5uC-2p9nC:
undetectable
1w5uD-2p9nC:
undetectable		 1w5uC-2p9nC:
3.52
1w5uD-2p9nC:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		4 / 7 SER C 215
ASP C 230
SER C 211
ASN C 213
 None
 1.11A 2cmlA-2p9nC:
11.4		 2cmlA-2p9nC:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		4 / 8 SER C 215
ASP C 230
SER C 211
ASN C 213
 None
 1.12A 2cmlC-2p9nC:
5.2		 2cmlC-2p9nC:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		3 / 3 TRP C 104
ALA C  76
VAL C  78
 None
 0.62A 2izqA-2p9nC:
undetectable
2izqB-2p9nC:
undetectable		 2izqA-2p9nC:
3.52
2izqB-2p9nC:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		4 / 5 PRO C 140
ILE C 141
ARG C 142
ASP C 163
 None
 1.40A 2rhmD-2p9nC:
undetectable		 2rhmD-2p9nC:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		5 / 11 LEU C 335
LEU C 362
ILE C 371
VAL C 259
ILE C 332
 None
 1.19A 2uxoB-2p9nC:
undetectable		 2uxoB-2p9nC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVO_A_PAUA314_0
(PANTOTHENATE KINASE)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		5 / 11 VAL C 113
LEU C  90
TYR C  77
HIS C  51
ILE C  95
 None
 1.46A 3avoA-2p9nC:
0.0		 3avoA-2p9nC:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		4 / 5 PRO C  10
THR C  69
VAL C  58
GLY C  57
 None
 1.13A 3elzA-2p9nC:
undetectable		 3elzA-2p9nC:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		5 / 12 LEU C 228
VAL C 220
GLY C 207
ILE C 332
ILE C 253
 None
 1.02A 3ijdB-2p9nC:
undetectable		 3ijdB-2p9nC:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		4 / 6 VAL C 359
SER C 257
LEU C 247
LEU C 285
 None
 0.90A 3kk6A-2p9nC:
undetectable		 3kk6A-2p9nC:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		4 / 6 VAL C 359
SER C 257
LEU C 247
LEU C 285
 None
 0.90A 3kk6B-2p9nC:
undetectable		 3kk6B-2p9nC:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		3 / 3 ALA C  76
VAL C  78
TRP C 104
 None
 0.62A 3l8lA-2p9nC:
undetectable
3l8lB-2p9nC:
undetectable		 3l8lA-2p9nC:
3.52
3l8lB-2p9nC:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		3 / 3 ALA C  76
VAL C  78
TRP C 104
 None
 0.62A 3l8lC-2p9nC:
undetectable
3l8lD-2p9nC:
undetectable		 3l8lC-2p9nC:
3.52
3l8lD-2p9nC:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		4 / 5 PHE C   6
ILE C  25
GLY C 352
HIS C   4
 None
 1.29A 3r0lD-2p9nC:
undetectable		 3r0lD-2p9nC:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		5 / 12 LEU C  93
VAL C 113
PHE C 111
VAL C  91
HIS C 136
 None
 1.30A 3u9fB-2p9nC:
undetectable
3u9fC-2p9nC:
undetectable		 3u9fB-2p9nC:
21.68
3u9fC-2p9nC:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		5 / 12 LEU C  93
VAL C 113
PHE C 111
VAL C  91
HIS C 136
 None
 1.25A 3u9fH-2p9nC:
undetectable
3u9fI-2p9nC:
undetectable		 3u9fH-2p9nC:
21.68
3u9fI-2p9nC:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		5 / 12 LEU C  93
VAL C 113
PHE C 111
VAL C  91
HIS C 136
 None
 1.30A 3u9fJ-2p9nC:
undetectable
3u9fK-2p9nC:
undetectable		 3u9fJ-2p9nC:
21.68
3u9fK-2p9nC:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		5 / 11 LEU C  93
VAL C 113
PHE C 111
VAL C  91
HIS C 136
 None
 1.26A 3u9fN-2p9nC:
undetectable
3u9fO-2p9nC:
undetectable		 3u9fN-2p9nC:
21.68
3u9fO-2p9nC:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		5 / 12 HIS C 136
LEU C  93
VAL C 113
PHE C 111
VAL C  91
 None
 1.30A 3u9fP-2p9nC:
undetectable
3u9fS-2p9nC:
undetectable		 3u9fP-2p9nC:
21.68
3u9fS-2p9nC:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		3 / 3 SER C  64
ASP C  59
ASP C 149
 None
 0.90A 4mwzA-2p9nC:
undetectable		 4mwzA-2p9nC:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B
(Bos
taurus) 		4 / 5 ALA C 218
GLY C 160
CYH C 166
LYS C 165
 None
 1.49A 5jliA-2p9nC:
undetectable		 5jliA-2p9nC:
16.58