SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2p9r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2p9r ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 6 VAL A 182
VAL A 198
ILE A 152
ARG A 124
 None
 1.13A 1iepA-2p9rA:
undetectable		 1iepA-2p9rA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2p9r ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 5 VAL A 183
VAL A 184
ARG A 191
LYS A 103
 None
 1.43A 3rv5A-2p9rA:
undetectable
3rv5B-2p9rA:
undetectable		 3rv5A-2p9rA:
19.23
3rv5B-2p9rA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 2p9r ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 4 LEU A 164
GLY A 163
LEU A 160
GLU A 161
 None
 0.98A 3tgvB-2p9rA:
undetectable		 3tgvB-2p9rA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2p9r ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		3 / 3 THR A 192
HIS A 133
LEU A 135
 None
 0.86A 5axdC-2p9rA:
undetectable		 5axdC-2p9rA:
11.90