SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pa1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SG9_A_SAMA301_1 (HEMK PROTEIN)	2pa1	PDZ AND LIM DOMAIN PROTEIN 2 (Homo sapiens)	4 / 4	THR A 30 GLY A 20 ASP A 22 ALA A 65	None	1.26A	1sg9A-2pa1A: undetectable	1sg9A-2pa1A: 14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QO6_A_CHDA130_0 (LIVER-BASIC FATTY ACID BINDING PROTEIN)	2pa1	PDZ AND LIM DOMAIN PROTEIN 2 (Homo sapiens)	5 / 12	ILE A 52 LEU A 78 ALA A 38 VAL A 32 HIS A 62	None	1.28A	2qo6A-2pa1A: undetectable	2qo6A-2pa1A: 20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SP9_A_IL2A901_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR DELTA)	2pa1	PDZ AND LIM DOMAIN PROTEIN 2 (Homo sapiens)	5 / 12	THR A 30 LEU A 78 VAL A 7 ILE A 69 HIS A 62	None	1.10A	3sp9A-2pa1A: undetectable	3sp9A-2pa1A: 15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KOX_A_RFPA502_1 (PENTACHLOROPHENOL 4-MONOOXYGENASE)	2pa1	PDZ AND LIM DOMAIN PROTEIN 2 (Homo sapiens)	6 / 12	GLY A 59 ARG A 70 ILE A 69 THR A 18 GLY A 19 GLY A 20	None	1.29A	5koxA-2pa1A: undetectable	5koxA-2pa1A: 12.83

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1SG9_A_SAMA301_1","HEMK PROTEIN","2pa1","PDZ AND LIM DOMAIN PROTEIN 2","Homo sapiens",4,"THR A  30;GLY A  20;ASP A  22;ALA A  65","None","1.26A","1sg9A-2pa1A:undetectable","1sg9A-2pa1A:14.91"],["2QO6_A_CHDA130_0","LIVER-BASIC FATTY ACID BINDING PROTEIN","2pa1","PDZ AND LIM DOMAIN PROTEIN 2","Homo sapiens",5,"ILE A  52;LEU A  78;ALA A  38;VAL A  32;HIS A  62","None","1.28A","2qo6A-2pa1A:undetectable","2qo6A-2pa1A:20.74"],["3SP9_A_IL2A901_1","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA","2pa1","PDZ AND LIM DOMAIN PROTEIN 2","Homo sapiens",5,"THR A  30;LEU A  78;VAL A   7;ILE A  69;HIS A  62","None","1.10A","3sp9A-2pa1A:undetectable","3sp9A-2pa1A:15.93"],["5KOX_A_RFPA502_1","PENTACHLOROPHENOL 4-MONOOXYGENASE","2pa1","PDZ AND LIM DOMAIN PROTEIN 2","Homo sapiens",6,"GLY A  59;ARG A  70;ILE A  69;THR A  18;GLY A  19;GLY A  20","None","1.29A","5koxA-2pa1A:undetectable","5koxA-2pa1A:12.83"]]