SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pa4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 THR A  32
THR A  30
PRO A  34
 None
 0.79A 1a7yB-2pa4A:
undetectable		 1a7yB-2pa4A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 7 ARG A  25
ASP A 142
ASP A 143
TYR A 179
 None
MG  A 325 ( 2.6A)
UPG  A 326 (-3.5A)
UPG  A 326 (-4.6A)
 1.11A 1ceaB-2pa4A:
undetectable		 1ceaB-2pa4A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 7 ARG A  25
ASP A 142
ASP A 143
TYR A 179
 None
MG  A 325 ( 2.6A)
UPG  A 326 (-3.5A)
UPG  A 326 (-4.6A)
 0.88A 1cebA-2pa4A:
undetectable		 1cebA-2pa4A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 ASP A 221
VAL A 165
HIS A 253
GLY A 162
 None
 0.68A 1ekjA-2pa4A:
undetectable
1ekjB-2pa4A:
undetectable		 1ekjA-2pa4A:
22.26
1ekjB-2pa4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 ASP A 266
GLY A 271
THR A  30
ASP A 142
 MG  A 325 ( 4.6A)
None
None
MG  A 325 ( 2.6A)
 0.86A 1m4iA-2pa4A:
undetectable		 1m4iA-2pa4A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 LEU A  61
ALA A  53
LEU A  56
ARG A 217
TYR A 218
 None
 1.26A 1mx8A-2pa4A:
undetectable		 1mx8A-2pa4A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 THR A  32
THR A  30
PRO A  34
 None
 0.74A 1qfiB-2pa4A:
undetectable		 1qfiB-2pa4A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 THR A  30
PRO A  34
THR A  32
 None
 0.82A 209dC-2pa4A:
undetectable		 209dC-2pa4A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 LEU A 248
ARG A 222
VAL A 122
GLY A 123
 None
 0.93A 2qd5B-2pa4A:
undetectable		 2qd5B-2pa4A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 5 PRO A 141
ILE A  46
GLY A  45
LYS A  35
 UPG  A 326 (-4.2A)
None
None
UPG  A 326 (-3.0A)
 0.95A 2qeuA-2pa4A:
undetectable
2qeuC-2pa4A:
undetectable		 2qeuA-2pa4A:
19.94
2qeuC-2pa4A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 SER A 210
ALA A 214
THR A 242
ILE A 245
 None
UPG  A 326 (-3.9A)
UPG  A 326 (-4.3A)
None
 0.87A 3bpxA-2pa4A:
undetectable
3bpxB-2pa4A:
undetectable		 3bpxA-2pa4A:
19.18
3bpxB-2pa4A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 GLY A 123
GLN A 112
ILE A 224
VAL A 136
VAL A 138
 None
UPG  A 326 (-3.2A)
None
None
None
 1.38A 3fi0D-2pa4A:
undetectable		 3fi0D-2pa4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 GLY A 123
GLN A 112
ILE A 224
VAL A 136
VAL A  16
 None
UPG  A 326 (-3.2A)
None
None
None
 1.24A 3fi0F-2pa4A:
undetectable		 3fi0F-2pa4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 GLY A 123
GLN A 112
ILE A 224
VAL A 136
VAL A 138
 None
UPG  A 326 (-3.2A)
None
None
None
 1.36A 3fi0F-2pa4A:
undetectable		 3fi0F-2pa4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 GLY A 123
GLN A 112
ILE A 224
VAL A 136
VAL A  16
 None
UPG  A 326 (-3.2A)
None
None
None
 1.23A 3fi0J-2pa4A:
undetectable		 3fi0J-2pa4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 GLY A 123
GLN A 112
ILE A 224
VAL A 136
VAL A 138
 None
UPG  A 326 (-3.2A)
None
None
None
 1.40A 3fi0J-2pa4A:
undetectable		 3fi0J-2pa4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 GLY A 123
GLN A 112
ILE A 224
VAL A 136
VAL A  16
 None
UPG  A 326 (-3.2A)
None
None
None
 1.18A 3fi0R-2pa4A:
undetectable		 3fi0R-2pa4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 GLY A 123
GLN A 112
ILE A 224
VAL A 136
VAL A 138
 None
UPG  A 326 (-3.2A)
None
None
None
 1.35A 3fi0R-2pa4A:
undetectable		 3fi0R-2pa4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 ALA A 121
LEU A 228
VAL A 138
ILE A 245
LEU A 166
 UPG  A 326 (-3.5A)
None
None
None
None
 1.25A 3jw3B-2pa4A:
undetectable		 3jw3B-2pa4A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 10 ALA A 121
LEU A 228
VAL A 138
ILE A 245
LEU A 166
 UPG  A 326 (-3.5A)
None
None
None
None
 1.13A 3jw5B-2pa4A:
undetectable		 3jw5B-2pa4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 ASP A 103
ARG A  78
ALA A 102
 None
 0.78A 3mbgC-2pa4A:
undetectable		 3mbgC-2pa4A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 6 ALA A 107
ILE A  63
LEU A  61
GLU A  77
ALA A 102
 None
 1.49A 3r9sA-2pa4A:
undetectable		 3r9sA-2pa4A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A 119
LEU A 116
LEU A 239
LYS A 114
ALA A 125
 None
 1.15A 4lg1B-2pa4A:
undetectable		 4lg1B-2pa4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 GLY A  21
GLN A 112
LYS A  69
 UPG  A 326 (-3.4A)
UPG  A 326 (-3.2A)
UPG  A 326 ( 4.3A)
 0.76A 5imsB-2pa4A:
undetectable		 5imsB-2pa4A:
21.26