SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pa5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		5 / 11 ARG A 409
GLY A 472
TRP A 468
GLN A 559
THR A 524
 None
None
None
CL  A 590 ( 4.8A)
None
 1.48A 1v54G-2pa5A:
0.0
1v54N-2pa5A:
0.0
1v54O-2pa5A:
0.0		 1v54G-2pa5A:
12.87
1v54N-2pa5A:
17.34
1v54O-2pa5A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		5 / 11 ARG A 409
GLY A 472
TRP A 468
GLN A 559
THR A 524
 None
None
None
CL  A 590 ( 4.8A)
None
 1.45A 1v55G-2pa5A:
0.0
1v55N-2pa5A:
0.0
1v55O-2pa5A:
0.0		 1v55G-2pa5A:
12.87
1v55N-2pa5A:
17.34
1v55O-2pa5A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		4 / 5 GLY A 518
GLN A 376
VAL A 336
SER A 516
 None
None
None
CL  A 591 (-2.9A)
 1.48A 1zzuA-2pa5A:
undetectable		 1zzuA-2pa5A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		5 / 11 ARG A 409
GLY A 472
TRP A 468
GLN A 559
THR A 524
 None
None
None
CL  A 590 ( 4.8A)
None
 1.49A 2eikG-2pa5A:
0.0
2eikN-2pa5A:
0.0
2eikO-2pa5A:
0.0		 2eikG-2pa5A:
12.87
2eikN-2pa5A:
17.34
2eikO-2pa5A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		3 / 3 ASN A 331
ASN A 359
ARG A 554
 None
 0.79A 2rlcA-2pa5A:
undetectable		 2rlcA-2pa5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		4 / 7 ILE A 511
LEU A 528
PHE A 525
PHE A 483
 None
 1.05A 2vctD-2pa5A:
undetectable		 2vctD-2pa5A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		6 / 12 ILE A 373
THR A 375
VAL A 512
GLU A 392
GLN A 393
PRO A 510
 None
 1.39A 2yzqA-2pa5A:
undetectable		 2yzqA-2pa5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		3 / 3 ARG A 343
ASP A 385
ASN A 327
 None
 0.85A 2zzmA-2pa5A:
undetectable		 2zzmA-2pa5A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		5 / 11 ARG A 409
GLY A 472
TRP A 468
GLN A 559
THR A 524
 None
None
None
CL  A 590 ( 4.8A)
None
 1.40A 3ag3G-2pa5A:
0.0
3ag3N-2pa5A:
0.0
3ag3O-2pa5A:
0.0		 3ag3G-2pa5A:
12.87
3ag3N-2pa5A:
17.34
3ag3O-2pa5A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		5 / 11 ILE A 373
ILE A 398
ILE A 358
VAL A 395
PRO A 510
 None
 0.94A 3tmzA-2pa5A:
undetectable		 3tmzA-2pa5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		5 / 12 ILE A 481
ALA A 477
LEU A 535
LEU A 541
ILE A 288
 SCN  A 601 (-3.5A)
SCN  A 601 ( 4.3A)
None
None
None
 0.97A 3uvvA-2pa5A:
undetectable		 3uvvA-2pa5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		5 / 12 ILE A 481
ALA A 575
LEU A 535
LEU A 541
ILE A 288
 SCN  A 601 (-3.5A)
None
None
None
None
 0.83A 3uvvA-2pa5A:
undetectable		 3uvvA-2pa5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		5 / 12 GLY A 377
VAL A 336
ILE A 519
GLY A 374
ILE A 373
 None
 1.03A 4jecB-2pa5A:
undetectable		 4jecB-2pa5A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		4 / 5 GLU A 305
GLU A 308
TYR A 307
GLU A 306
 None
 1.32A 4r87E-2pa5A:
undetectable		 4r87E-2pa5A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		4 / 7 ASN A 433
TYR A 415
LEU A 429
PHE A 428
 None
 1.21A 4yv5A-2pa5A:
undetectable		 4yv5A-2pa5A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		3 / 3 VAL A 512
ARG A 423
PRO A 417
 None
 0.87A 5koxA-2pa5A:
undetectable		 5koxA-2pa5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		4 / 6 ASN A 370
ALA A 371
PRO A 509
ASP A 364
 None
 1.22A 5umd2-2pa5A:
undetectable
5umdF-2pa5A:
undetectable		 5umd2-2pa5A:
13.55
5umdF-2pa5A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		4 / 6 VAL A 512
LEU A 434
ARG A 423
PRO A 417
 None
 1.33A 6brdB-2pa5A:
undetectable		 6brdB-2pa5A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		5 / 9 HIS A 450
ARG A 458
ALA A 494
VAL A 495
SER A 496
 None
 1.22A 6c2mA-2pa5A:
undetectable		 6c2mA-2pa5A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		5 / 12 GLY A 377
VAL A 336
ILE A 519
GLY A 374
ILE A 373
 None
 1.05A 6dh3B-2pa5A:
undetectable		 6dh3B-2pa5A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens) 		5 / 10 ARG A 409
GLY A 472
TRP A 468
GLN A 559
THR A 524
 None
None
None
CL  A 590 ( 4.8A)
None
 1.46A 6nmfG-2pa5A:
0.0
6nmfN-2pa5A:
0.0
6nmfO-2pa5A:
0.0		 6nmfG-2pa5A:
12.87
6nmfN-2pa5A:
17.34
6nmfO-2pa5A:
22.80