SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pa6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ASP A  60
LEU A  71
GLY A  69
PHE A  65
VAL A  74
 None
 1.48A 1axwB-2pa6A:
undetectable		 1axwB-2pa6A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		6 / 12 GLY A 177
ALA A 178
ILE A 181
VAL A 185
GLY A 188
ILE A 173
 None
 1.40A 1hshA-2pa6A:
undetectable		 1hshA-2pa6A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 VAL A 340
LEU A 380
SER A 386
VAL A 363
 None
 1.13A 1jtvA-2pa6A:
undetectable		 1jtvA-2pa6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A 184
TYR A 403
ILE A 173
PRO A 175
 None
 1.05A 1oniA-2pa6A:
undetectable
1oniB-2pa6A:
undetectable		 1oniA-2pa6A:
17.28
1oniB-2pa6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ALA A 184
TYR A 403
ILE A 173
PRO A 175
 None
 1.04A 1oniB-2pa6A:
undetectable
1oniC-2pa6A:
undetectable		 1oniB-2pa6A:
17.28
1oniC-2pa6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		4 / 7 TYR A 403
ILE A 173
PRO A 175
ALA A 184
 None
 0.99A 1oniD-2pa6A:
undetectable
1oniE-2pa6A:
undetectable		 1oniD-2pa6A:
17.28
1oniE-2pa6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ALA A 184
TYR A 403
ILE A 173
PRO A 175
 None
 1.05A 1oniH-2pa6A:
undetectable
1oniI-2pa6A:
undetectable		 1oniH-2pa6A:
17.28
1oniI-2pa6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  51
ASP A 104
ILE A  81
ASN A 115
ILE A 117
 None
 1.22A 1q8jB-2pa6A:
7.6		 1q8jB-2pa6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 173
ALA A 395
GLY A 215
LEU A 229
LEU A 195
 None
 0.96A 1rjdA-2pa6A:
undetectable		 1rjdA-2pa6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 173
ALA A 395
GLY A 215
LEU A 229
LEU A 195
 None
 1.00A 1rjdB-2pa6A:
undetectable		 1rjdB-2pa6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 173
ALA A 395
GLY A 215
LEU A 229
LEU A 195
 None
 0.98A 1rjdC-2pa6A:
undetectable		 1rjdC-2pa6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 177
ALA A 178
ILE A 181
GLY A 188
ILE A 173
 None
 0.92A 1sguB-2pa6A:
undetectable		 1sguB-2pa6A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 177
ALA A 178
ILE A 181
GLY A 188
ILE A 173
 None
 0.86A 2b60A-2pa6A:
undetectable		 2b60A-2pa6A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A 177
ALA A 178
ILE A 181
GLY A 188
ILE A 173
 None
 0.86A 2b60B-2pa6A:
undetectable		 2b60B-2pa6A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA A 349
LEU A 140
LEU A 380
ALA A 383
VAL A 365
 None
 0.94A 2bxgB-2pa6A:
2.1		 2bxgB-2pa6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 177
ALA A 178
ILE A 181
GLY A 188
ILE A 173
 None
 0.94A 2hs1A-2pa6A:
undetectable		 2hs1A-2pa6A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		6 / 12 GLY A 177
ALA A 178
ILE A 181
VAL A 185
GLY A 188
ILE A 173
 None
 1.39A 2rkgA-2pa6A:
undetectable		 2rkgA-2pa6A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 177
ALA A 178
ILE A 181
GLY A 188
ILE A 173
 None
 0.92A 2rkgB-2pa6A:
undetectable		 2rkgB-2pa6A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLN A 411
LEU A 140
ASP A 379
SER A 145
ALA A 383
 None
 1.13A 3d91A-2pa6A:
undetectable		 3d91A-2pa6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A 177
ALA A 178
ILE A 181
GLY A 188
ILE A 173
 None
 0.94A 3s53A-2pa6A:
undetectable		 3s53A-2pa6A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ARG A  64
SER A 110
GLU A  18
ALA A  73
ASN A  76
 None
 1.28A 3sxjA-2pa6A:
undetectable		 3sxjA-2pa6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ARG A  64
SER A 110
GLU A  18
ALA A  73
ASN A  76
 None
 1.29A 3sxjB-2pa6A:
undetectable		 3sxjB-2pa6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE A 317
PHE A 300
ALA A 301
THR A 304
 None
 1.16A 3t3sB-2pa6A:
undetectable		 3t3sB-2pa6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ILE A  99
ILE A  11
TYR A  88
GLU A  10
 None
 0.98A 4a99D-2pa6A:
undetectable		 4a99D-2pa6A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A 213
GLY A 370
TYR A 403
ASN A 154
VAL A 155
 None
 1.43A 4ffwA-2pa6A:
undetectable		 4ffwA-2pa6A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 272
LEU A 273
ILE A 309
ILE A 311
LEU A 247
 None
 1.15A 4j24A-2pa6A:
undetectable		 4j24A-2pa6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 272
LEU A 273
ILE A 309
ILE A 311
LEU A 247
 None
 1.16A 4j24C-2pa6A:
undetectable		 4j24C-2pa6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 336
LEU A 337
ILE A 377
ILE A 389
LEU A 384
 None
 1.30A 4j24C-2pa6A:
undetectable		 4j24C-2pa6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 272
LEU A 273
ILE A 309
ILE A 311
LEU A 247
 None
 1.18A 4j26B-2pa6A:
undetectable		 4j26B-2pa6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 336
LEU A 337
ILE A 377
ILE A 389
LEU A 384
 None
 1.25A 4j26B-2pa6A:
undetectable		 4j26B-2pa6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 338
GLY A 362
ALA A 335
ILE A 328
THR A 319
 None
 0.94A 4njtB-2pa6A:
undetectable		 4njtB-2pa6A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A 392
GLU A 213
GLU A 289
ALA A 246
 None
 0.84A 4rjdA-2pa6A:
undetectable
4rjdB-2pa6A:
undetectable		 4rjdA-2pa6A:
10.97
4rjdB-2pa6A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		4 / 5 GLU A 213
ALA A 393
ASN A 157
GLU A 170
 None
 1.31A 5dwkC-2pa6A:
undetectable		 5dwkC-2pa6A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		6 / 12 GLY A 177
ALA A 178
ILE A 181
VAL A 185
GLY A 188
ILE A 173
 None
 1.39A 5e5jA-2pa6A:
undetectable		 5e5jA-2pa6A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		6 / 12 GLY A 177
ALA A 178
ILE A 181
VAL A 185
GLY A 188
ILE A 173
 None
 1.40A 5e5kA-2pa6A:
undetectable		 5e5kA-2pa6A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 VAL A 364
GLU A 213
GLU A 170
 None
 0.91A 5jsdB-2pa6A:
undetectable
5jsdC-2pa6A:
undetectable		 5jsdB-2pa6A:
20.90
5jsdC-2pa6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		6 / 12 GLY A 177
ALA A 178
ILE A 181
VAL A 185
GLY A 188
ILE A 173
 None
 1.45A 5t8hB-2pa6A:
undetectable		 5t8hB-2pa6A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A 204
THR A 222
PRO A 219
 None
 0.65A 5v5zA-2pa6A:
undetectable		 5v5zA-2pa6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A 258
ARG A 269
TYR A 276
ASP A 296
 None
 1.03A 5vlmB-2pa6A:
undetectable		 5vlmB-2pa6A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 178
VAL A 191
TYR A 239
 None
 0.69A 5zmqH-2pa6A:
undetectable		 5zmqH-2pa6A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2pa6 ENOLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A 346
ASP A  89
ILE A  11
 None
 0.57A 6dh0B-2pa6A:
undetectable		 6dh0B-2pa6A:
12.75