SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pae'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2pae DTDP-6-DEOXY-3,4-KET
O-HEXULOSE ISOMERASE
(Aneurinibacillus
thermoaerophilus) 		3 / 3 SER A  64
ASP A 103
ASP A  99
 None
 0.70A 3iv6A-2paeA:
undetectable		 3iv6A-2paeA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2pae DTDP-6-DEOXY-3,4-KET
O-HEXULOSE ISOMERASE
(Aneurinibacillus
thermoaerophilus) 		4 / 6 LEU A  87
TYR A  88
LYS A   4
LEU A  69
 None
 1.15A 4f3tA-2paeA:
undetectable		 4f3tA-2paeA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2pae DTDP-6-DEOXY-3,4-KET
O-HEXULOSE ISOMERASE
(Aneurinibacillus
thermoaerophilus) 		4 / 7 ASN A  49
GLY A  47
PHE A 100
ILE A  37
 None
 0.91A 4fglC-2paeA:
undetectable		 4fglC-2paeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2pae DTDP-6-DEOXY-3,4-KET
O-HEXULOSE ISOMERASE
(Aneurinibacillus
thermoaerophilus) 		3 / 3 ALA A 131
ASN A 134
LEU A 135
 None
 0.40A 5i1nB-2paeA:
undetectable		 5i1nB-2paeA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2pae DTDP-6-DEOXY-3,4-KET
O-HEXULOSE ISOMERASE
(Aneurinibacillus
thermoaerophilus) 		3 / 3 ALA A 131
ASN A 134
LEU A 135
 None
 0.46A 5i1oA-2paeA:
undetectable		 5i1oA-2paeA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2pae DTDP-6-DEOXY-3,4-KET
O-HEXULOSE ISOMERASE
(Aneurinibacillus
thermoaerophilus) 		4 / 5 LEU A  87
TYR A  88
LYS A   4
LEU A  69
 None
 1.20A 5ki6A-2paeA:
undetectable		 5ki6A-2paeA:
9.95