SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2paf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2paf LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		3 / 3 ILE A 123
ILE A  64
THR A  68
 None
 0.63A 1rg7A-2pafA:
undetectable		 1rg7A-2pafA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 2paf LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		3 / 3 SER A  85
ARG A  86
GLN A  89
 None
 0.88A 2xnrA-2pafA:
undetectable		 2xnrA-2pafA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2paf LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		3 / 3 SER A  85
GLU A 277
ASP A 247
 None
 0.68A 2zulA-2pafA:
4.5		 2zulA-2pafA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 2paf LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		4 / 4 THR A 229
VAL A 264
GLY A 272
THR A 288
 None
 1.07A 3cflA-2pafA:
undetectable		 3cflA-2pafA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2paf LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		3 / 3 SER A  85
GLU A 277
ASP A 247
 None
 0.73A 3dmhA-2pafA:
5.7		 3dmhA-2pafA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2paf LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		5 / 12 GLU A 217
GLY A 218
GLY A 187
ASN A 246
MET A 249
 None
None
None
NPF  A 902 (-3.7A)
None
 1.21A 3ps9A-2pafA:
4.7		 3ps9A-2pafA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2paf LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		4 / 5 LEU A 115
LEU A 114
LEU A  63
SER A 120
 None
 0.85A 3vhuA-2pafA:
undetectable		 3vhuA-2pafA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 2paf LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		4 / 7 ASP A 247
GLY A 252
SER A 279
THR A 276
 None
 0.65A 4ac9C-2pafA:
5.4		 4ac9C-2pafA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 2paf LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		3 / 3 VAL A 150
SER A 151
THR A 154
 None
 0.40A 4luhA-2pafA:
undetectable		 4luhA-2pafA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2paf LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		5 / 11 GLY A 103
ASP A 149
ASN A 125
SER A 158
ASP A 129
 None
NPF  A 902 (-3.8A)
NPF  A 902 (-2.6A)
None
None
 1.48A 4rtrA-2pafA:
4.3		 4rtrA-2pafA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2paf LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		3 / 3 VAL A 324
THR A 288
ARG A 326
 None
 0.74A 5b2sB-2pafA:
2.7		 5b2sB-2pafA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2paf LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		3 / 3 VAL A 324
THR A 288
ARG A 326
 None
 0.76A 5b2tB-2pafA:
2.8		 5b2tB-2pafA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2paf LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		5 / 9 SER A 120
GLY A  65
ALA A  87
VAL A  94
ILE A 123
 None
 1.45A 5i3cA-2pafA:
undetectable		 5i3cA-2pafA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2paf LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		5 / 9 ASP A 247
ASN A 246
SER A 279
SER A 280
THR A 329
 None
NPF  A 902 (-3.7A)
None
None
None
 1.21A 6awpA-2pafA:
undetectable		 6awpA-2pafA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 2paf LACTOSE OPERON
REPRESSOR
(Escherichia
coli) 		4 / 6 ASP A 274
ASN A 125
LEU A  71
SER A  70
 NPF  A 902 (-2.6A)
NPF  A 902 (-2.6A)
None
None
 1.11A 6ekuA-2pafA:
undetectable		 6ekuA-2pafA:
17.62