SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pan'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		3 / 3 VAL A 232
VAL A 234
TRP A 348
 None
 0.99A 1bdwA-2panA:
undetectable
1bdwB-2panA:
undetectable		 1bdwA-2panA:
7.35
1bdwB-2panA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		4 / 8 ALA A 196
LEU A 200
ALA A 333
THR A 230
 None
 0.91A 1ie4B-2panA:
undetectable
1ie4D-2panA:
undetectable		 1ie4B-2panA:
11.91
1ie4D-2panA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		4 / 7 GLN A 258
PHE A 365
MET A 403
ALA A 401
 DTT  A 901 ( 3.8A)
None
None
None
 1.28A 1linA-2panA:
undetectable		 1linA-2panA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 11 GLN A 537
ILE A 531
ALA A 534
VAL A 551
LEU A 555
 None
 1.23A 1n4hA-2panA:
undetectable		 1n4hA-2panA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		4 / 8 ASP A 302
SER A  94
ARG A 154
ALA A 322
 FAD  A 701 (-2.8A)
FAD  A 701 ( 3.8A)
FAD  A 701 (-4.8A)
FAD  A 701 (-3.5A)
 1.07A 1rqpC-2panA:
undetectable		 1rqpC-2panA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		4 / 8 ASP A 302
SER A  94
ARG A 154
ALA A 322
 FAD  A 701 (-2.8A)
FAD  A 701 ( 3.8A)
FAD  A 701 (-4.8A)
FAD  A 701 (-3.5A)
 1.02A 1rqpA-2panA:
undetectable		 1rqpA-2panA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 7 PRO A 155
GLY A 156
PRO A 157
THR A  62
ILE A  97
 FAD  A 701 ( 4.8A)
None
None
None
None
 1.33A 1usqF-2panA:
undetectable		 1usqF-2panA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 1utdT-2panA:
undetectable
1utdU-2panA:
undetectable		 1utdT-2panA:
9.74
1utdU-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		4 / 6 TYR A  34
GLY A  53
PHE A  23
SER A  55
 None
 1.10A 2a3cA-2panA:
undetectable		 2a3cA-2panA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		4 / 6 TYR A  34
GLY A  53
PHE A  23
SER A  55
 None
 1.17A 2a3cB-2panA:
undetectable		 2a3cB-2panA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 7 PRO A 155
GLY A 156
PRO A 157
THR A  62
ILE A  97
 FAD  A 701 ( 4.8A)
None
None
None
None
 1.39A 2jkjE-2panA:
undetectable		 2jkjE-2panA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 7 PRO A 155
GLY A 156
PRO A 157
THR A  62
ILE A  97
 FAD  A 701 ( 4.8A)
None
None
None
None
 1.37A 2jklE-2panA:
undetectable		 2jklE-2panA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7J_A_TESA203_1
(ANDROGEN RECEPTOR)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 12 LEU A  73
LEU A  47
GLN A 461
MET A  37
THR A  21
 None
 1.30A 2q7jA-2panA:
undetectable		 2q7jA-2panA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YHD_A_TESA1920_1
(ANDROGEN RECEPTOR)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 12 LEU A  73
LEU A  47
GLN A 461
MET A  37
THR A  21
 None
 1.33A 2yhdA-2panA:
undetectable		 2yhdA-2panA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 12 ALA A  58
GLU A  59
MET A  83
LEU A  87
GLY A  74
 None
 1.21A 2yjaB-2panA:
undetectable		 2yjaB-2panA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		4 / 7 ARG A  63
ALA A  92
PRO A 420
ALA A 418
 None
 1.09A 2zgwA-2panA:
undetectable		 2zgwA-2panA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		4 / 5 HIS A  40
ASP A   8
TYR A  12
PRO A 175
 None
 1.48A 3fo7A-2panA:
undetectable		 3fo7A-2panA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		4 / 5 HIS A  40
ASP A   8
TYR A  12
PRO A 175
 None
 1.43A 3h1xA-2panA:
undetectable		 3h1xA-2panA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		3 / 3 GLY A 242
ILE A 235
VAL A 234
 None
 0.50A 3nv6A-2panA:
undetectable		 3nv6A-2panA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 11 ALA A  58
GLU A  59
MET A  83
LEU A  87
GLY A  74
 None
 1.24A 3uudA-2panA:
undetectable		 3uudA-2panA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1227_0
(THAUMATIN-LIKE
PROTEIN)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		4 / 4 THR A  62
ARG A  63
ASN A 216
ILE A  95
 None
None
FAD  A 701 (-3.9A)
None
 1.39A 3zs3A-2panA:
0.0		 3zs3A-2panA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		4 / 5 THR A  21
ILE A  43
GLU A  15
PHE A  33
 None
 1.46A 4acbC-2panA:
undetectable		 4acbC-2panA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 12 ILE A 443
ALA A 399
LEU A 555
ILE A 531
PRO A 528
 None
 1.17A 4gh8A-2panA:
undetectable		 4gh8A-2panA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 12 ILE A 443
ALA A 399
LEU A 555
ILE A 531
PRO A 528
 None
 1.17A 4gh8B-2panA:
undetectable		 4gh8B-2panA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		6 / 9 LEU A 200
LEU A 326
GLN A 225
PHE A 226
THR A 230
LEU A 342
 None
 1.32A 4ltwA-2panA:
undetectable		 4ltwA-2panA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 12 ASP A 530
ILE A 523
ALA A 538
GLN A 537
PHE A 535
 None
 1.26A 4wh5A-2panA:
undetectable		 4wh5A-2panA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		3 / 3 GLU A  52
ILE A 393
ALA A 427
 None
TDP  A 801 ( 4.1A)
None
 0.57A 4wnwB-2panA:
undetectable		 4wnwB-2panA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 12 LEU A 222
LEU A 329
VAL A 214
ALA A 219
ILE A 301
 None
 0.93A 4x20B-2panA:
undetectable		 4x20B-2panA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 276
VAL A 209
VAL A 274
HIS A 285
LEU A 268
 None
None
None
FAD  A 701 (-3.9A)
None
 1.26A 4yb6A-2panA:
undetectable
4yb6E-2panA:
undetectable		 4yb6A-2panA:
19.43
4yb6E-2panA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 276
VAL A 209
VAL A 274
HIS A 285
LEU A 268
 None
None
None
FAD  A 701 (-3.9A)
None
 1.26A 4yb6B-2panA:
1.3
4yb6C-2panA:
undetectable		 4yb6B-2panA:
19.43
4yb6C-2panA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 HIS A 285
LEU A 268
GLY A 276
VAL A 209
VAL A 274
 FAD  A 701 (-3.9A)
None
None
None
None
 1.26A 4yb6B-2panA:
1.3
4yb6F-2panA:
1.7		 4yb6B-2panA:
19.43
4yb6F-2panA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		4 / 6 VAL A 234
LEU A 326
ILE A 277
ALA A 210
 None
 0.72A 4zf8A-2panA:
undetectable		 4zf8A-2panA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		4 / 7 ALA A 227
ASP A 246
GLY A 253
THR A 259
 None
None
None
FAD  A 701 (-3.2A)
 0.89A 5btgA-2panA:
undetectable
5btgC-2panA:
undetectable
5btgD-2panA:
undetectable		 5btgA-2panA:
24.57
5btgC-2panA:
24.57
5btgD-2panA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 11 ALA A  58
GLU A  59
MET A  83
LEU A  87
GLY A  74
 None
 1.20A 5dxbB-2panA:
undetectable		 5dxbB-2panA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 11 ALA A  58
GLU A  59
MET A  83
LEU A  87
GLY A  74
 None
 1.22A 5dxgB-2panA:
undetectable		 5dxgB-2panA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.10A 5eeuF-2panA:
undetectable
5eeuG-2panA:
undetectable		 5eeuF-2panA:
9.74
5eeuG-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 12 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.10A 5eeuI-2panA:
undetectable
5eeuJ-2panA:
undetectable		 5eeuI-2panA:
9.74
5eeuJ-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.12A 5eeuO-2panA:
undetectable
5eeuP-2panA:
undetectable		 5eeuO-2panA:
9.74
5eeuP-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 5eeuQ-2panA:
undetectable
5eeuR-2panA:
undetectable		 5eeuQ-2panA:
9.74
5eeuR-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.10A 5eevF-2panA:
undetectable
5eevG-2panA:
undetectable		 5eevF-2panA:
9.74
5eevG-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 12 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.09A 5eevI-2panA:
undetectable
5eevJ-2panA:
undetectable		 5eevI-2panA:
9.74
5eevJ-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 5eevO-2panA:
undetectable
5eevP-2panA:
undetectable		 5eevO-2panA:
9.74
5eevP-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 5eevQ-2panA:
undetectable
5eevR-2panA:
undetectable		 5eevQ-2panA:
9.74
5eevR-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.10A 5eewF-2panA:
undetectable
5eewG-2panA:
undetectable		 5eewF-2panA:
9.74
5eewG-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 12 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.09A 5eewI-2panA:
undetectable
5eewJ-2panA:
undetectable		 5eewI-2panA:
9.74
5eewJ-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.12A 5eewO-2panA:
undetectable
5eewP-2panA:
undetectable		 5eewO-2panA:
9.74
5eewP-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 5eewQ-2panA:
undetectable
5eewR-2panA:
undetectable		 5eewQ-2panA:
9.74
5eewR-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.10A 5eexF-2panA:
undetectable
5eexG-2panA:
undetectable		 5eexF-2panA:
9.74
5eexG-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.12A 5eexO-2panA:
undetectable
5eexP-2panA:
undetectable		 5eexO-2panA:
9.74
5eexP-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.11A 5eeyF-2panA:
undetectable
5eeyG-2panA:
undetectable		 5eeyF-2panA:
9.74
5eeyG-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 5eeyO-2panA:
undetectable
5eeyP-2panA:
undetectable		 5eeyO-2panA:
9.74
5eeyP-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.11A 5eezF-2panA:
undetectable
5eezG-2panA:
undetectable		 5eezF-2panA:
9.74
5eezG-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 5eezO-2panA:
undetectable
5eezP-2panA:
undetectable		 5eezO-2panA:
9.74
5eezP-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.10A 5ef0F-2panA:
undetectable
5ef0G-2panA:
undetectable		 5ef0F-2panA:
9.74
5ef0G-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 5ef0O-2panA:
undetectable
5ef0P-2panA:
undetectable		 5ef0O-2panA:
9.74
5ef0P-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.11A 5ef1F-2panA:
undetectable
5ef1G-2panA:
undetectable		 5ef1F-2panA:
9.74
5ef1G-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 5ef1O-2panA:
undetectable
5ef1P-2panA:
undetectable		 5ef1O-2panA:
9.74
5ef1P-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.11A 5ef2F-2panA:
undetectable
5ef2G-2panA:
undetectable		 5ef2F-2panA:
9.74
5ef2G-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.11A 5ef3F-2panA:
undetectable
5ef3G-2panA:
undetectable		 5ef3F-2panA:
9.74
5ef3G-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		4 / 4 LEU A 456
TYR A 545
PRO A 465
ILE A 464
 None
 1.36A 5esgA-2panA:
undetectable		 5esgA-2panA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		3 / 3 THR A 132
PRO A 163
ASP A 165
 None
 0.88A 5l8dB-2panA:
undetectable		 5l8dB-2panA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		3 / 3 THR A 132
PRO A 163
ASP A 165
 None
 0.88A 5mwuB-2panA:
undetectable		 5mwuB-2panA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		4 / 8 VAL A 509
ASP A 510
GLY A 517
LEU A 518
 None
 0.93A 5w3jB-2panA:
2.4		 5w3jB-2panA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 12 GLY A 276
VAL A 299
ALA A 196
LEU A 326
ALA A 203
 None
 0.99A 5xv7A-2panA:
undetectable		 5xv7A-2panA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 12 GLY A 278
ASP A 302
ILE A 303
ASP A 321
ALA A 322
 FAD  A 701 (-4.0A)
FAD  A 701 (-2.8A)
FAD  A 701 (-3.7A)
FAD  A 701 (-4.0A)
FAD  A 701 (-3.5A)
 0.60A 6bq4A-2panA:
3.2		 6bq4A-2panA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 12 GLY A 278
ASP A 302
ILE A 303
ASP A 321
ALA A 322
 FAD  A 701 (-4.0A)
FAD  A 701 (-2.8A)
FAD  A 701 (-3.7A)
FAD  A 701 (-4.0A)
FAD  A 701 (-3.5A)
 0.57A 6bq4B-2panA:
undetectable		 6bq4B-2panA:
10.85