SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pb9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 2pb9 PHOSPHOMETHYLPYRIMID
INE KINASE
(Pyrococcus
furiosus) 		4 / 8 ALA A 338
ALA A 315
SER A 302
ALA A 343
 None
 0.87A 2vh3B-2pb9A:
undetectable		 2vh3B-2pb9A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2pb9 PHOSPHOMETHYLPYRIMID
INE KINASE
(Pyrococcus
furiosus) 		4 / 6 ARG A 271
ILE A 272
ILE A 321
LEU A 342
 None
None
None
PO4  A 500 (-4.5A)
 0.97A 2xkwB-2pb9A:
undetectable		 2xkwB-2pb9A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2pb9 PHOSPHOMETHYLPYRIMID
INE KINASE
(Pyrococcus
furiosus) 		4 / 7 ALA A 401
ILE A 403
ARG A 351
GLY A 406
 None
 0.99A 3v4tH-2pb9A:
undetectable		 3v4tH-2pb9A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 2pb9 PHOSPHOMETHYLPYRIMID
INE KINASE
(Pyrococcus
furiosus) 		4 / 6 ILE A 292
PRO A 293
HIS A 423
ILE A 369
 None
 0.98A 4zj8A-2pb9A:
undetectable		 4zj8A-2pb9A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 2pb9 PHOSPHOMETHYLPYRIMID
INE KINASE
(Pyrococcus
furiosus) 		4 / 5 HIS A 341
VAL A 300
GLY A 337
ALA A 338
 PO4  A 500 (-4.2A)
None
None
None
 1.00A 5hwaA-2pb9A:
undetectable		 5hwaA-2pb9A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 2pb9 PHOSPHOMETHYLPYRIMID
INE KINASE
(Pyrococcus
furiosus) 		3 / 3 TYR A 301
PRO A 304
LEU A 303
 None
 0.73A 6beoA-2pb9A:
undetectable		 6beoA-2pb9A:
4.27