SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pbe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		4 / 5 SER A  89
THR A 103
GLU A  75
GLY A  85
 None
 0.87A 1icrA-2pbeA:
undetectable
1icrB-2pbeA:
undetectable		 1icrA-2pbeA:
19.87
1icrB-2pbeA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		4 / 5 GLU A  75
GLY A  85
SER A  89
THR A 103
 None
 0.88A 1icrA-2pbeA:
undetectable
1icrB-2pbeA:
undetectable		 1icrA-2pbeA:
19.87
1icrB-2pbeA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		4 / 6 SER A  89
THR A 103
GLU A  75
GLY A  85
 None
 0.92A 1icuA-2pbeA:
undetectable
1icuB-2pbeA:
undetectable		 1icuA-2pbeA:
19.87
1icuB-2pbeA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		4 / 6 GLU A  75
GLY A  85
SER A  89
THR A 103
 None
 0.90A 1icuA-2pbeA:
undetectable
1icuB-2pbeA:
undetectable		 1icuA-2pbeA:
19.87
1icuB-2pbeA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		4 / 6 SER A  89
THR A 103
GLU A  75
GLY A  85
 None
 0.92A 1icuC-2pbeA:
undetectable
1icuD-2pbeA:
undetectable		 1icuC-2pbeA:
19.87
1icuD-2pbeA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		4 / 5 SER A  89
THR A 103
GLU A  75
GLY A  85
 None
 0.90A 1icvC-2pbeA:
undetectable
1icvD-2pbeA:
undetectable		 1icvC-2pbeA:
19.87
1icvD-2pbeA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		4 / 5 GLU A  75
GLY A  85
SER A  89
THR A 103
 None
 0.90A 1icvC-2pbeA:
undetectable
1icvD-2pbeA:
undetectable		 1icvC-2pbeA:
19.87
1icvD-2pbeA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		4 / 6 SER A  89
THR A 103
GLU A  75
GLY A  85
 None
 0.93A 1kqbA-2pbeA:
undetectable
1kqbB-2pbeA:
undetectable		 1kqbA-2pbeA:
19.73
1kqbB-2pbeA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		4 / 5 GLU A  75
GLY A  85
SER A  89
THR A 103
 None
 0.94A 1kqbA-2pbeA:
undetectable
1kqbB-2pbeA:
undetectable		 1kqbA-2pbeA:
19.73
1kqbB-2pbeA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		4 / 6 SER A  89
THR A 103
GLU A  75
GLY A  85
 None
 0.89A 1kqbC-2pbeA:
undetectable
1kqbD-2pbeA:
undetectable		 1kqbC-2pbeA:
19.73
1kqbD-2pbeA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		4 / 6 GLU A  75
GLY A  85
SER A  89
THR A 103
 None
 0.92A 1kqbC-2pbeA:
undetectable
1kqbD-2pbeA:
undetectable		 1kqbC-2pbeA:
19.73
1kqbD-2pbeA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		3 / 3 ASP A 139
TYR A 142
LYS A 213
 None
 1.02A 2othA-2pbeA:
undetectable		 2othA-2pbeA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		4 / 6 ARG A  68
PHE A  65
ILE A  64
PHE A  14
 None
 1.18A 2qeiA-2pbeA:
undetectable		 2qeiA-2pbeA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		3 / 3 VAL A 257
SER A 200
LEU A 261
 None
 0.75A 3n8xA-2pbeA:
undetectable		 3n8xA-2pbeA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OSH_A_OINA5811_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		5 / 9 LEU A 125
PHE A 206
ILE A 144
TRP A 143
GLY A 203
 None
 1.38A 3oshA-2pbeA:
undetectable		 3oshA-2pbeA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		5 / 12 TYR A  90
GLU A  53
GLU A  75
PHE A  88
VAL A  52
 None
 1.46A 3qwuA-2pbeA:
2.4		 3qwuA-2pbeA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		4 / 8 TYR A 212
TYR A 231
LEU A 182
MET A 239
 None
 1.40A 3uzzB-2pbeA:
undetectable		 3uzzB-2pbeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		4 / 4 LEU A 182
ILE A 279
TYR A 236
TYR A 247
 None
 1.47A 3vt7A-2pbeA:
undetectable		 3vt7A-2pbeA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		3 / 3 THR A 230
THR A 245
PHE A 250
 None
 0.63A 5cxvA-2pbeA:
undetectable		 5cxvA-2pbeA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E
(Bacillus
subtilis) 		4 / 7 PHE A  14
ASP A  18
ILE A  21
VAL A  49
 None
 0.79A 5ik1A-2pbeA:
1.7		 5ik1A-2pbeA:
20.19