SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pbg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 8 VAL A 331
ASN A 270
GLY A 272
LEU A 274
 None
 0.86A 1dzmA-2pbgA:
undetectable		 1dzmA-2pbgA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		5 / 10 THR A 250
ALA A 287
GLY A 213
THR A 157
ILE A 212
 None
 1.20A 1gtnB-2pbgA:
undetectable
1gtnC-2pbgA:
undetectable		 1gtnB-2pbgA:
10.65
1gtnC-2pbgA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		5 / 10 GLY A 213
THR A 157
ILE A 212
THR A 250
ALA A 287
 None
 1.18A 1gtnU-2pbgA:
undetectable
1gtnV-2pbgA:
undetectable		 1gtnU-2pbgA:
10.65
1gtnV-2pbgA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 6 LEU A 284
ASP A 280
LEU A 276
ARG A 132
 None
 0.67A 1mt1A-2pbgA:
undetectable
1mt1F-2pbgA:
undetectable		 1mt1A-2pbgA:
8.62
1mt1F-2pbgA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 6 ARG A 132
LEU A 284
ASP A 280
LEU A 276
 None
 0.61A 1mt1B-2pbgA:
undetectable
1mt1C-2pbgA:
undetectable		 1mt1B-2pbgA:
13.23
1mt1C-2pbgA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 6 LEU A 284
ASP A 280
LEU A 276
ARG A 132
 None
 0.62A 1mt1G-2pbgA:
undetectable
1mt1J-2pbgA:
undetectable		 1mt1G-2pbgA:
8.62
1mt1J-2pbgA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 7 ARG A 132
LEU A 284
ASP A 280
LEU A 276
 None
 0.60A 1mt1H-2pbgA:
undetectable
1mt1K-2pbgA:
undetectable		 1mt1H-2pbgA:
13.23
1mt1K-2pbgA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 5 ARG A 132
LEU A 284
ASP A 280
LEU A 276
 None
 0.69A 1n13B-2pbgA:
undetectable
1n13C-2pbgA:
undetectable		 1n13B-2pbgA:
13.23
1n13C-2pbgA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 7 ARG A 132
LEU A 284
ASP A 280
LEU A 276
 None
 0.66A 1n13D-2pbgA:
undetectable
1n13E-2pbgA:
undetectable		 1n13D-2pbgA:
13.23
1n13E-2pbgA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 8 LEU A 284
ASP A 280
LEU A 276
ARG A 132
 None
 0.72A 1n13A-2pbgA:
undetectable
1n13F-2pbgA:
undetectable		 1n13A-2pbgA:
8.62
1n13F-2pbgA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 6 ARG A 132
LEU A 284
ASP A 280
LEU A 276
 None
 0.70A 1n13H-2pbgA:
undetectable
1n13K-2pbgA:
undetectable		 1n13H-2pbgA:
13.23
1n13K-2pbgA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 7 LEU A 284
ASP A 280
LEU A 276
ARG A 132
 None
 0.69A 1n13G-2pbgA:
undetectable
1n13J-2pbgA:
undetectable		 1n13G-2pbgA:
8.62
1n13J-2pbgA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 7 LEU A 284
ASP A 280
LEU A 276
ARG A 132
 None
 0.72A 1n13I-2pbgA:
undetectable
1n13L-2pbgA:
undetectable		 1n13I-2pbgA:
8.62
1n13L-2pbgA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		3 / 3 ASP A  59
LEU A  60
HIS A 116
 None
 0.79A 1qknA-2pbgA:
undetectable		 1qknA-2pbgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 6 ILE A 266
VAL A 263
VAL A 194
ILE A 135
 None
 0.85A 1uwhB-2pbgA:
undetectable		 1uwhB-2pbgA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 7 TYR A 458
GLU A 375
THR A  15
VAL A  68
 None
 1.16A 2fb2B-2pbgA:
3.7		 2fb2B-2pbgA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		3 / 3 ASN A 243
LEU A 247
HIS A 216
 None
 0.86A 2q6fB-2pbgA:
undetectable		 2q6fB-2pbgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 7 ARG A 132
LEU A 284
ASP A 280
LEU A 276
 None
 0.69A 2qqcB-2pbgA:
undetectable
2qqcC-2pbgA:
undetectable		 2qqcB-2pbgA:
15.97
2qqcC-2pbgA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 7 LEU A 284
ASP A 280
LEU A 276
ARG A 132
 None
 0.68A 2qqcA-2pbgA:
undetectable
2qqcF-2pbgA:
undetectable		 2qqcA-2pbgA:
8.37
2qqcF-2pbgA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 7 ARG A 132
LEU A 284
ASP A 280
LEU A 276
 None
 0.63A 2qqcD-2pbgA:
undetectable
2qqcE-2pbgA:
undetectable		 2qqcD-2pbgA:
15.97
2qqcE-2pbgA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 7 LEU A 284
ASP A 280
LEU A 276
ARG A 132
 None
 0.65A 2qqcG-2pbgA:
undetectable
2qqcJ-2pbgA:
undetectable		 2qqcG-2pbgA:
8.37
2qqcJ-2pbgA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 7 LEU A 284
ASP A 280
LEU A 276
ARG A 132
 None
 0.67A 2qqcI-2pbgA:
undetectable
2qqcL-2pbgA:
undetectable		 2qqcI-2pbgA:
8.37
2qqcL-2pbgA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 8 ARG A 132
LEU A 284
ASP A 280
LEU A 276
 None
 0.63A 2qqcH-2pbgA:
undetectable
2qqcK-2pbgA:
undetectable		 2qqcH-2pbgA:
15.97
2qqcK-2pbgA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 7 LEU A 284
ASP A 280
LEU A 276
ARG A 132
 None
 0.65A 2qqdA-2pbgA:
undetectable
2qqdE-2pbgA:
undetectable		 2qqdA-2pbgA:
7.21
2qqdE-2pbgA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 8 ARG A 132
LEU A 284
ASP A 280
LEU A 276
 None
 0.70A 2qqdB-2pbgA:
undetectable
2qqdC-2pbgA:
undetectable		 2qqdB-2pbgA:
15.97
2qqdC-2pbgA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		5 / 11 ASN A 159
GLU A 160
TYR A 299
GLU A 375
TRP A 421
 None
 0.90A 2v3dB-2pbgA:
17.1		 2v3dB-2pbgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 5 ILE A 246
THR A 157
PHE A 138
PHE A 129
 None
 0.86A 3em0A-2pbgA:
undetectable		 3em0A-2pbgA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 4 LEU A 274
MET A 192
ILE A 328
ASP A 239
 None
 1.49A 3hecA-2pbgA:
undetectable		 3hecA-2pbgA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		6 / 10 LEU A 218
VAL A 361
ILE A 373
LEU A 354
ILE A 371
THR A 250
 None
 1.47A 3jw3A-2pbgA:
undetectable		 3jw3A-2pbgA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 6 ASN A 297
ILE A 296
GLU A 375
ASN A 376
 None
 1.38A 3kp6A-2pbgA:
0.0
3kp6B-2pbgA:
undetectable		 3kp6A-2pbgA:
16.02
3kp6B-2pbgA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 5 PHE A 149
ILE A  75
GLY A  92
HIS A  97
 None
 1.10A 3r0lD-2pbgA:
undetectable		 3r0lD-2pbgA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		5 / 9 ASN A 316
GLY A 319
ASN A 431
GLY A 322
ASP A 346
 None
None
SO4  A 469 (-4.5A)
None
None
 1.24A 3ztvA-2pbgA:
0.9		 3ztvA-2pbgA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		5 / 12 LEU A 218
SER A 430
SER A 428
PHE A 117
ASN A 159
 None
SO4  A 469 ( 4.4A)
SO4  A 469 (-2.8A)
None
None
 1.44A 4amjB-2pbgA:
undetectable		 4amjB-2pbgA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 6 GLY A  70
VAL A 108
PRO A 110
GLU A 102
 None
 0.80A 4dxuA-2pbgA:
undetectable		 4dxuA-2pbgA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 8 GLY A 295
LYS A 370
TYR A 372
GLU A 211
 None
 0.89A 4hyfB-2pbgA:
undetectable		 4hyfB-2pbgA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		3 / 3 ASP A 118
TRP A 421
SER A  74
 None
 1.01A 4lrhB-2pbgA:
undetectable		 4lrhB-2pbgA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		3 / 3 ASP A 118
TRP A 421
SER A  74
 None
 1.08A 4lrhF-2pbgA:
undetectable		 4lrhF-2pbgA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		3 / 3 ASP A 392
LYS A 452
LEU A 439
 None
 1.05A 4ptjA-2pbgA:
undetectable		 4ptjA-2pbgA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 7 ASN A 431
LYS A 435
TYR A 441
PHE A 440
 SO4  A 469 (-4.5A)
SO4  A 469 ( 3.9A)
None
None
 1.25A 4yv5A-2pbgA:
undetectable		 4yv5A-2pbgA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 7 HIS A 196
GLY A 213
ASN A 291
HIS A 216
 None
 1.16A 5a5zC-2pbgA:
undetectable		 5a5zC-2pbgA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 5 TYR A  37
GLY A 167
TYR A  42
GLY A 317
 None
 1.06A 5ayfA-2pbgA:
undetectable		 5ayfA-2pbgA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 5 TYR A  37
GLY A 172
TYR A  42
GLY A 317
 None
 1.03A 5ayfA-2pbgA:
undetectable		 5ayfA-2pbgA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		5 / 10 GLY A 213
THR A 157
ILE A 212
THR A 250
ALA A 287
 None
 1.20A 5eeuQ-2pbgA:
undetectable
5eeuR-2pbgA:
undetectable		 5eeuQ-2pbgA:
10.65
5eeuR-2pbgA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		5 / 10 GLY A 213
THR A 157
ILE A 212
THR A 250
ALA A 287
 None
 1.19A 5eevQ-2pbgA:
undetectable
5eevR-2pbgA:
undetectable		 5eevQ-2pbgA:
10.65
5eevR-2pbgA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		5 / 10 GLY A 213
THR A 157
ILE A 212
THR A 250
ALA A 287
 None
 1.19A 5eewQ-2pbgA:
undetectable
5eewR-2pbgA:
undetectable		 5eewQ-2pbgA:
10.65
5eewR-2pbgA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		3 / 3 ASP A 356
SER A 301
TYR A 222
 None
 0.91A 5glmA-2pbgA:
undetectable		 5glmA-2pbgA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		3 / 3 TYR A  53
TYR A 141
SER A  78
 None
 0.87A 5iktB-2pbgA:
0.1		 5iktB-2pbgA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		5 / 12 PHE A 186
HIS A 190
SER A 195
ILE A 135
ARG A 277
 None
 1.43A 5uacC-2pbgA:
0.0		 5uacC-2pbgA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 7 GLY A  84
TYR A  96
ASP A 118
ASP A 128
 None
 1.01A 5vlmE-2pbgA:
undetectable		 5vlmE-2pbgA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 6 GLY A 393
ASP A 391
SER A 454
ARG A 394
 None
 1.02A 6dwdA-2pbgA:
undetectable
6dwdC-2pbgA:
undetectable		 6dwdA-2pbgA:
20.45
6dwdC-2pbgA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 7 PHE A   9
GLY A  13
ALA A  14
VAL A 215
 None
 0.80A 6dwnB-2pbgA:
undetectable		 6dwnB-2pbgA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 8 ARG A 333
VAL A 185
ARG A 360
GLN A 357
 None
 1.28A 6fbvD-2pbgA:
0.0		 6fbvD-2pbgA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 6 PRO A 175
TRP A  34
TYR A  42
GLU A  39
 None
 1.08A 6gqiA-2pbgA:
undetectable		 6gqiA-2pbgA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		5 / 10 PHE A 111
TYR A  96
PHE A 100
PHE A 149
VAL A 152
 None
 1.47A 6hu9C-2pbgA:
undetectable		 6hu9C-2pbgA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE
(Lactococcus
lactis) 		4 / 8 ASP A 166
HIS A 116
HIS A 242
GLU A 160
 None
 1.14A 6mn4B-2pbgA:
undetectable		 6mn4B-2pbgA:
20.13