SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pbh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2pbh PROCATHEPSIN B
(Homo
sapiens) 		5 / 10 GLY A  74
ALA A  79
HIS A 199
THR A  44
ALA A  34
 None
 1.41A 1gtnO-2pbhA:
undetectable
1gtnP-2pbhA:
undetectable		 1gtnO-2pbhA:
11.78
1gtnP-2pbhA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 2pbh PROCATHEPSIN B
(Homo
sapiens) 		4 / 8 PHE A   5
TRP A  11
GLY A 168
ASP A  40
 None
 1.00A 1rmtC-2pbhA:
undetectable		 1rmtC-2pbhA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 2pbh PROCATHEPSIN B
(Homo
sapiens) 		8 / 10 GLN A  23
GLY A  27
SER A  28
TRP A  30
PHE A  32
HIS A 199
ALA A 200
GLY A  43
 None
 0.54A 1stfE-2pbhA:
24.8
1stfI-2pbhA:
undetectable		 1stfE-2pbhA:
28.05
1stfI-2pbhA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2pbh PROCATHEPSIN B
(Homo
sapiens) 		5 / 12 GLY A  33
SER A 220
VAL A 247
ALA A  79
ALA A  34
 None
 1.37A 2avdA-2pbhA:
undetectable		 2avdA-2pbhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2pbh PROCATHEPSIN B
(Homo
sapiens) 		4 / 5 LEU A 181
VAL A 246
MET A 195
ARG A 235
 None
 1.11A 2oiqA-2pbhA:
undetectable		 2oiqA-2pbhA:
19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 2pbh PROCATHEPSIN B
(Homo
sapiens) 		4 / 7 GLN A  23
GLY A  27
HIS A 199
TRP A 221
 None
 0.43A 3ai8A-2pbhA:
39.7		 3ai8A-2pbhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 2pbh PROCATHEPSIN B
(Homo
sapiens) 		4 / 8 GLY A 205
TYR A 214
GLN A 237
GLU A 157
 None
 0.92A 3s3mA-2pbhA:
undetectable		 3s3mA-2pbhA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 2pbh PROCATHEPSIN B
(Homo
sapiens) 		4 / 8 GLY A 205
TYR A 214
GLN A 237
GLU A 157
 None
 0.96A 3s3nA-2pbhA:
undetectable		 3s3nA-2pbhA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2pbh PROCATHEPSIN B
(Homo
sapiens) 		5 / 9 SER A 220
ASN A 222
ILE A  20
GLY A 229
ASP A 224
 None
 1.24A 4fxsA-2pbhA:
undetectable		 4fxsA-2pbhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 2pbh PROCATHEPSIN B
(Homo
sapiens) 		5 / 12 GLU A  53
VAL A  54
THR A 223
TRP A 225
GLY A 229
 None
 1.05A 4olfA-2pbhA:
undetectable		 4olfA-2pbhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2pbh PROCATHEPSIN B
(Homo
sapiens) 		5 / 12 GLY A  33
ILE A  38
SER A  39
SER A  28
ALA A  31
 None
 1.17A 4qtuD-2pbhA:
undetectable		 4qtuD-2pbhA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 2pbh PROCATHEPSIN B
(Homo
sapiens) 		3 / 3 VAL A 208
GLU A 243
GLU A 157
 None
 0.78A 5jsdB-2pbhA:
undetectable
5jsdC-2pbhA:
undetectable		 5jsdB-2pbhA:
17.48
5jsdC-2pbhA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2pbh PROCATHEPSIN B
(Homo
sapiens) 		3 / 3 ASP A   6
PHE A 230
ARG A 202
 None
 1.14A 5yw0A-2pbhA:
undetectable		 5yw0A-2pbhA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 2pbh PROCATHEPSIN B
(Homo
sapiens) 		5 / 12 GLU A 171
ILE A 201
GLY A 172
ALA A  77
VAL A 217
 None
 0.91A 6iftA-2pbhA:
undetectable		 6iftA-2pbhA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 2pbh PROCATHEPSIN B
(Homo
sapiens) 		5 / 12 GLU A  53
VAL A  54
THR A 223
TRP A 225
GLY A 229
 None
 1.05A 6mn8A-2pbhA:
undetectable		 6mn8A-2pbhA:
17.86