SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pbj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		3 / 3 ALA A 316
VAL A 318
TRP A 234
 None
 0.92A 1grmA-2pbjA:
undetectable		 1grmA-2pbjA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		3 / 3 ALA A 316
VAL A 318
TRP A 234
 None
 0.92A 1grmB-2pbjA:
undetectable		 1grmB-2pbjA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		3 / 3 ARG A 322
VAL A 315
TRP A 314
 None
 1.18A 1qw6A-2pbjA:
undetectable		 1qw6A-2pbjA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		3 / 3 ARG A 322
VAL A 315
TRP A 314
 None
 1.19A 1qwcA-2pbjA:
undetectable		 1qwcA-2pbjA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		3 / 3 ARG A 322
VAL A 315
TRP A 314
 None
 1.19A 1vagA-2pbjA:
undetectable		 1vagA-2pbjA:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		12 / 12 TYR A 107
THR A 109
CYH A 110
PRO A 111
PRO A 134
VAL A 250
TYR A 251
SER A 260
TYR A 263
ILE A 264
VAL A 343
LEU A 347
 HEM  A 476 (-4.0A)
HEM  A 476 (-4.1A)
GSH  A 477 (-3.3A)
HEM  A 476 (-4.2A)
HEM  A 476 (-4.1A)
None
None
None
None
HEM  A 476 (-4.7A)
None
None
 0.31A 1z9hA-2pbjA:
44.7		 1z9hA-2pbjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		12 / 12 TYR A 107
THR A 109
CYH A 110
PRO A 111
PRO A 134
VAL A 250
TYR A 251
SER A 260
TYR A 263
ILE A 264
VAL A 343
LEU A 347
 HEM  A 476 (-4.0A)
HEM  A 476 (-4.1A)
GSH  A 477 (-3.3A)
HEM  A 476 (-4.2A)
HEM  A 476 (-4.1A)
None
None
None
None
HEM  A 476 (-4.7A)
None
None
 0.31A 1z9hB-2pbjA:
44.7		 1z9hB-2pbjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		12 / 12 TYR A 107
THR A 109
CYH A 110
PRO A 111
PRO A 134
VAL A 250
TYR A 251
SER A 260
TYR A 263
ILE A 264
VAL A 343
LEU A 347
 HEM  A 476 (-4.0A)
HEM  A 476 (-4.1A)
GSH  A 477 (-3.3A)
HEM  A 476 (-4.2A)
HEM  A 476 (-4.1A)
None
None
None
None
HEM  A 476 (-4.7A)
None
None
 0.31A 1z9hC-2pbjA:
44.6		 1z9hC-2pbjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		12 / 12 THR A 109
CYH A 110
PRO A 111
PRO A 134
ILE A 246
VAL A 250
TYR A 251
SER A 260
TYR A 263
ILE A 264
VAL A 343
LEU A 347
 HEM  A 476 (-4.1A)
GSH  A 477 (-3.3A)
HEM  A 476 (-4.2A)
HEM  A 476 (-4.1A)
HEM  A 476 ( 3.8A)
None
None
None
None
HEM  A 476 (-4.7A)
None
None
 0.35A 1z9hD-2pbjA:
44.7		 1z9hD-2pbjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		3 / 3 ARG A 322
VAL A 315
TRP A 314
 None
 1.19A 1zviA-2pbjA:
undetectable		 1zviA-2pbjA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		5 / 12 TYR A 107
PHE A 261
PHE A 270
GLY A 282
ILE A 140
 HEM  A 476 (-4.0A)
None
None
None
None
 1.20A 3ld6A-2pbjA:
undetectable		 3ld6A-2pbjA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		4 / 6 SER A 178
LEU A 176
HIS A 123
THR A 174
 None
 1.23A 3thrB-2pbjA:
undetectable		 3thrB-2pbjA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		3 / 3 ASP A 351
GLU A 345
GLY A 346
 None
 0.64A 3w9tA-2pbjA:
undetectable		 3w9tA-2pbjA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		3 / 3 PRO A 134
TYR A 107
GLY A 268
 HEM  A 476 (-4.1A)
HEM  A 476 (-4.0A)
None
 0.71A 4g2zA-2pbjA:
undetectable		 4g2zA-2pbjA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		5 / 10 LEU A 182
LEU A 162
ALA A 153
LEU A 120
LEU A 100
 None
 1.12A 4p65A-2pbjA:
undetectable
4p65B-2pbjA:
undetectable
4p65F-2pbjA:
undetectable
4p65H-2pbjA:
undetectable		 4p65A-2pbjA:
3.79
4p65B-2pbjA:
9.02
4p65F-2pbjA:
9.02
4p65H-2pbjA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		4 / 9 ALA A 153
LEU A 125
LEU A 120
ILE A 169
 None
 0.93A 4xtaA-2pbjA:
undetectable		 4xtaA-2pbjA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		6 / 9 LEU A 100
LEU A 182
ALA A 171
LEU A 162
LEU A 151
LEU A 102
 None
 1.18A 4z91F-2pbjA:
1.2
4z91G-2pbjA:
1.7
4z91H-2pbjA:
1.5
4z91I-2pbjA:
undetectable
4z91J-2pbjA:
1.6		 4z91F-2pbjA:
22.54
4z91G-2pbjA:
22.54
4z91H-2pbjA:
22.54
4z91I-2pbjA:
22.54
4z91J-2pbjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		6 / 9 LEU A 102
LEU A 100
LEU A 182
ALA A 171
LEU A 162
LEU A 151
 None
 1.26A 4z91F-2pbjA:
1.2
4z91G-2pbjA:
1.7
4z91H-2pbjA:
1.5
4z91I-2pbjA:
undetectable
4z91J-2pbjA:
1.6		 4z91F-2pbjA:
22.54
4z91G-2pbjA:
22.54
4z91H-2pbjA:
22.54
4z91I-2pbjA:
22.54
4z91J-2pbjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		6 / 9 LEU A 162
LEU A 151
LEU A 102
LEU A 100
LEU A 182
ALA A 171
 None
 1.19A 4z91F-2pbjA:
1.2
4z91G-2pbjA:
1.7
4z91H-2pbjA:
1.5
4z91I-2pbjA:
undetectable
4z91J-2pbjA:
1.6		 4z91F-2pbjA:
22.54
4z91G-2pbjA:
22.54
4z91H-2pbjA:
22.54
4z91I-2pbjA:
22.54
4z91J-2pbjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		4 / 7 ARG A 252
TYR A 308
ASP A 348
ALA A 349
 None
 1.07A 4zz8A-2pbjA:
undetectable		 4zz8A-2pbjA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		3 / 3 ARG A 322
VAL A 315
TRP A 314
 None
 1.17A 5fvoA-2pbjA:
undetectable		 5fvoA-2pbjA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		3 / 3 ASP A 240
SER A 166
TYR A 209
 None
GSH  A 477 ( 4.6A)
None
 0.88A 5glmA-2pbjA:
undetectable		 5glmA-2pbjA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		5 / 12 LEU A 151
LEU A 172
LEU A 102
THR A 103
GLY A 156
 None
 1.00A 6b0cD-2pbjA:
undetectable		 6b0cD-2pbjA:
12.77