SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pbk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 8 LEU A  34
VAL A  36
THR A  55
VAL A 135
 None
 0.91A 1dz9A-2pbkA:
undetectable		 1dz9A-2pbkA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		3 / 3 ASP A 216
LEU A 213
HIS A  46
 None
 0.71A 1qknA-2pbkA:
undetectable		 1qknA-2pbkA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 8 LEU A  34
VAL A  36
THR A  55
VAL A 135
 None
 1.09A 1uyuA-2pbkA:
undetectable		 1uyuA-2pbkA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		5 / 9 ALA A  80
LEU A 102
TYR A 150
PHE A  76
LEU A   5
 None
ACT  A 602 (-4.0A)
None
None
None
 1.36A 1y7iA-2pbkA:
undetectable		 1y7iA-2pbkA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 8 ALA A  75
PHE A  76
ALA A  80
LEU A 106
 None
 0.94A 2bxmA-2pbkA:
undetectable		 2bxmA-2pbkA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 8 LEU A  34
VAL A  36
VAL A 135
LEU A 115
 None
 0.77A 2zujA-2pbkA:
undetectable		 2zujA-2pbkA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 7 PHE A  59
GLU A 168
SER A 167
VAL A 164
 None
 1.47A 3dqtA-2pbkA:
undetectable
3dqtB-2pbkA:
undetectable		 3dqtA-2pbkA:
20.91
3dqtB-2pbkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 7 SER A 167
VAL A 164
PHE A  59
GLU A 168
 None
 1.41A 3n5tA-2pbkA:
undetectable
3n5tB-2pbkA:
undetectable		 3n5tA-2pbkA:
19.82
3n5tB-2pbkA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 7 PHE A  59
GLU A 168
SER A 167
VAL A 164
 None
 1.45A 4k5jA-2pbkA:
undetectable
4k5jB-2pbkA:
undetectable		 4k5jA-2pbkA:
19.86
4k5jB-2pbkA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 8 LEU A 110
LEU A 106
LEU A 102
ILE A  44
 None
None
ACT  A 602 (-4.0A)
None
 0.79A 4klaA-2pbkA:
undetectable		 4klaA-2pbkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 8 GLY A   8
ILE A  71
LEU A 106
LEU A 110
 None
 0.78A 4mwzB-2pbkA:
undetectable		 4mwzB-2pbkA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		6 / 12 ILE A  65
VAL A  11
LEU A 113
ILE A  42
GLY A  69
LEU A  34
 ACT  A 601 (-4.5A)
None
None
None
None
None
 1.17A 4o1zA-2pbkA:
undetectable		 4o1zA-2pbkA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 5 LEU A  56
VAL A  52
TYR A   6
ARG A 142
 None
 1.09A 4r7iA-2pbkA:
undetectable		 4r7iA-2pbkA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 7 PHE A  59
GLU A 168
SER A 167
VAL A 164
 None
 1.42A 5adlA-2pbkA:
undetectable
5adlB-2pbkA:
undetectable		 5adlA-2pbkA:
19.86
5adlB-2pbkA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 7 PHE A  59
GLU A 168
SER A 167
VAL A 164
 None
 1.44A 5fj3A-2pbkA:
undetectable
5fj3B-2pbkA:
undetectable		 5fj3A-2pbkA:
19.86
5fj3B-2pbkA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		5 / 12 ILE A  42
LEU A 137
GLY A  69
GLY A   8
TYR A 150
 None
 1.06A 5nnaB-2pbkA:
undetectable		 5nnaB-2pbkA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 7 PHE A  59
GLU A 168
SER A 167
VAL A 164
 None
 1.45A 5vv7A-2pbkA:
undetectable
5vv7B-2pbkA:
undetectable		 5vv7A-2pbkA:
19.86
5vv7B-2pbkA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 7 PHE A  59
GLU A 168
SER A 167
VAL A 164
 None
 1.42A 5vvnA-2pbkA:
undetectable
5vvnB-2pbkA:
undetectable		 5vvnA-2pbkA:
19.86
5vvnB-2pbkA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		4 / 7 SER A 167
VAL A 164
PHE A  59
GLU A 168
 None
 1.45A 6av7A-2pbkA:
undetectable
6av7B-2pbkA:
undetectable		 6av7A-2pbkA:
15.35
6av7B-2pbkA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2pbk KSHV PROTEASE
(Human
gammaherpesvirus
8) 		6 / 12 GLY A  57
GLY A   8
GLY A  69
VAL A 135
ALA A 154
PHE A 161
 None
 1.45A 6nj9K-2pbkA:
undetectable		 6nj9K-2pbkA:
20.24