SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pbl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		4 / 6 PHE A  52
ALA A  96
ILE A 115
PRO A  98
 None
 1.19A 1oniH-2pblA:
0.9
1oniI-2pblA:
1.6		 1oniH-2pblA:
21.07
1oniI-2pblA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		4 / 7 GLU A 214
HIS A 135
TYR A  72
ILE A  13
 None
UNL  A 263 (-4.2A)
UNL  A 263 (-4.4A)
None
 1.10A 1tuvA-2pblA:
undetectable		 1tuvA-2pblA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 8 GLY A  70
GLY A  71
SER A 136
ALA A 137
HIS A 241
 UNL  A 263 ( 4.2A)
UNL  A 263 (-4.1A)
UNL  A 263 (-3.7A)
None
UNL  A 263 (-4.3A)
 0.35A 1yajC-2pblA:
16.7		 1yajC-2pblA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		6 / 8 GLY A 138
GLY A  70
GLY A  71
SER A 136
ALA A 137
HIS A 241
 None
UNL  A 263 ( 4.2A)
UNL  A 263 (-4.1A)
UNL  A 263 (-3.7A)
None
UNL  A 263 (-4.3A)
 1.21A 1yajC-2pblA:
16.7		 1yajC-2pblA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		4 / 4 GLY A 211
SER A 166
ILE A 245
HIS A 135
 None
None
None
UNL  A 263 (-4.2A)
 1.33A 1yajJ-2pblA:
9.2		 1yajJ-2pblA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 9 GLY A  70
GLY A  71
SER A 136
ALA A 137
HIS A 241
 UNL  A 263 ( 4.2A)
UNL  A 263 (-4.1A)
UNL  A 263 (-3.7A)
None
UNL  A 263 (-4.3A)
 0.78A 2aceA-2pblA:
17.8		 2aceA-2pblA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 ILE A 165
PHE A  67
SER A  26
ALA A  25
ILE A 245
 None
 1.32A 2xkwB-2pblA:
undetectable		 2xkwB-2pblA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA301_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		4 / 6 TRP A  73
ILE A 111
VAL A  68
HIS A  69
 None
 1.48A 3deuA-2pblA:
undetectable		 3deuA-2pblA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 11 ALA A 123
THR A 120
ALA A 122
ALA A 157
GLY A 156
 None
 0.96A 3mg0K-2pblA:
undetectable
3mg0L-2pblA:
undetectable		 3mg0K-2pblA:
21.64
3mg0L-2pblA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.11A 3n8xA-2pblA:
undetectable		 3n8xA-2pblA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 11 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.13A 3n8yA-2pblA:
undetectable		 3n8yA-2pblA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 7 GLY A  70
GLY A  71
SER A 136
PHE A 218
HIS A 241
 UNL  A 263 ( 4.2A)
UNL  A 263 (-4.1A)
UNL  A 263 (-3.7A)
None
UNL  A 263 (-4.3A)
 1.10A 3o9mA-2pblA:
17.5		 3o9mA-2pblA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 LEU A 219
ASP A   5
GLY A  10
ILE A  13
SER A 166
 None
 0.80A 3ogqB-2pblA:
undetectable		 3ogqB-2pblA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		4 / 5 GLU A  46
GLY A  47
TYR A  44
GLN A 114
 None
 1.49A 3w9tB-2pblA:
undetectable		 3w9tB-2pblA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		4 / 5 GLU A  46
GLY A  47
TYR A  44
GLN A 114
 None
 1.46A 3w9tD-2pblA:
undetectable		 3w9tD-2pblA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.15A 4coxA-2pblA:
undetectable		 4coxA-2pblA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.17A 4coxB-2pblA:
undetectable		 4coxB-2pblA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		3 / 3 ASP A  53
ARG A  31
ASP A  77
 None
 0.57A 4fp9D-2pblA:
undetectable		 4fp9D-2pblA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		3 / 3 ASP A  53
ARG A  31
ASP A  77
 None
 0.80A 4fzvA-2pblA:
undetectable		 4fzvA-2pblA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 LEU A 151
ILE A 130
VAL A  66
LEU A 132
ALA A 118
 None
 1.11A 4o1zB-2pblA:
undetectable		 4o1zB-2pblA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.05A 4otyA-2pblA:
undetectable		 4otyA-2pblA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.05A 4otyB-2pblA:
undetectable		 4otyB-2pblA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.07A 4rrwA-2pblA:
undetectable		 4rrwA-2pblA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.11A 4rrwB-2pblA:
undetectable		 4rrwB-2pblA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.07A 4rrwC-2pblA:
undetectable		 4rrwC-2pblA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.07A 4rrzA-2pblA:
undetectable		 4rrzA-2pblA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.11A 4rrzB-2pblA:
undetectable		 4rrzB-2pblA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.07A 4rrzC-2pblA:
undetectable		 4rrzC-2pblA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.10A 5ikqA-2pblA:
undetectable		 5ikqA-2pblA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.10A 5ikqB-2pblA:
undetectable		 5ikqB-2pblA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		5 / 12 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
 None
None
None
UNL  A 263 (-3.7A)
None
 1.17A 5ikrA-2pblA:
undetectable		 5ikrA-2pblA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		4 / 6 ILE A 245
TYR A  19
TRP A  81
SER A  80
 None
 0.97A 5jwaH-2pblA:
undetectable		 5jwaH-2pblA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE
(Ruegeria
sp.
TM1040) 		3 / 3 ASP A  53
ARG A  31
ASP A  77
 None
 0.83A 5zvgB-2pblA:
undetectable		 5zvgB-2pblA:
20.47