SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pbp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2pbp ENOYL-COA HYDRATASE
SUBUNIT I
(Geobacillus
kaustophilus) 		5 / 11 PHE A  62
LEU A 115
ALA A 126
GLY A 104
PHE A 130
 None
 1.46A 1l5rA-2pbpA:
undetectable		 1l5rA-2pbpA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2pbp ENOYL-COA HYDRATASE
SUBUNIT I
(Geobacillus
kaustophilus) 		4 / 5 ILE A  18
PHE A  44
ASP A  45
GLU A  42
 None
 1.16A 3kp6A-2pbpA:
undetectable
3kp6B-2pbpA:
undetectable		 3kp6A-2pbpA:
21.40
3kp6B-2pbpA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 2pbp ENOYL-COA HYDRATASE
SUBUNIT I
(Geobacillus
kaustophilus) 		5 / 9 ARG A 196
ARG A  51
LEU A 197
GLU A 199
GLY A  13
 None
 1.42A 3nxuB-2pbpA:
undetectable		 3nxuB-2pbpA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2pbp ENOYL-COA HYDRATASE
SUBUNIT I
(Geobacillus
kaustophilus) 		4 / 7 GLY A 140
ALA A 141
ALA A  86
ASP A  87
 None
 0.87A 3ur0B-2pbpA:
undetectable		 3ur0B-2pbpA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2pbp ENOYL-COA HYDRATASE
SUBUNIT I
(Geobacillus
kaustophilus) 		5 / 12 ALA A 126
PHE A 128
ILE A  17
MET A 187
PHE A  62
 None
 1.47A 3wemA-2pbpA:
undetectable		 3wemA-2pbpA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2pbp ENOYL-COA HYDRATASE
SUBUNIT I
(Geobacillus
kaustophilus) 		4 / 7 ALA A 122
PHE A 128
ALA A 106
ALA A 100
 None
 0.84A 4du2A-2pbpA:
undetectable		 4du2A-2pbpA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2pbp ENOYL-COA HYDRATASE
SUBUNIT I
(Geobacillus
kaustophilus) 		4 / 7 ALA A 122
PHE A 128
ALA A 106
ALA A 100
 None
 0.78A 4du2B-2pbpA:
undetectable		 4du2B-2pbpA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 2pbp ENOYL-COA HYDRATASE
SUBUNIT I
(Geobacillus
kaustophilus) 		3 / 3 ARG A 146
GLU A 112
PHE A 130
 None
 1.00A 4kszA-2pbpA:
undetectable		 4kszA-2pbpA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2pbp ENOYL-COA HYDRATASE
SUBUNIT I
(Geobacillus
kaustophilus) 		5 / 11 ALA A 126
VAL A 177
LEU A 150
LEU A 115
PHE A 111
 None
 1.17A 4zmeA-2pbpA:
undetectable		 4zmeA-2pbpA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2pbp ENOYL-COA HYDRATASE
SUBUNIT I
(Geobacillus
kaustophilus) 		5 / 10 ALA A 126
VAL A 177
LEU A 150
LEU A 115
PHE A 111
 None
 1.18A 4zmeB-2pbpA:
undetectable		 4zmeB-2pbpA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2pbp ENOYL-COA HYDRATASE
SUBUNIT I
(Geobacillus
kaustophilus) 		5 / 12 ILE A  37
LEU A 115
LEU A 105
LEU A  20
PHE A  62
 None
 1.21A 5xxiA-2pbpA:
undetectable		 5xxiA-2pbpA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 2pbp ENOYL-COA HYDRATASE
SUBUNIT I
(Geobacillus
kaustophilus) 		3 / 3 PHE A 255
ARG A  51
GLN A 200
 None
 1.06A 6g1pB-2pbpA:
undetectable		 6g1pB-2pbpA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 2pbp ENOYL-COA HYDRATASE
SUBUNIT I
(Geobacillus
kaustophilus) 		5 / 12 LEU A  20
GLY A  57
PHE A  62
ASN A 103
ALA A   8
 None
 1.16A 6r2eE-2pbpA:
undetectable		 6r2eE-2pbpA:
22.52