SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pby'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		6 / 12 SER A  65
LYS A  68
ASN A 116
LYS A 259
SER A 260
GLY A 261
 None
 0.41A 1ghmA-2pbyA:
13.2		 1ghmA-2pbyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		5 / 11 LEU A 205
GLY A 265
GLY A 264
LEU A 283
LEU A  63
 None
 0.99A 1mx1A-2pbyA:
undetectable		 1mx1A-2pbyA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		5 / 12 ILE A  44
GLY A 275
GLY A 209
VAL A 270
PRO A  47
 None
 1.06A 1nv8A-2pbyA:
undetectable		 1nv8A-2pbyA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		5 / 12 ILE A  44
GLY A 275
GLY A 209
VAL A 270
PRO A  47
 None
 1.02A 1nv8B-2pbyA:
undetectable		 1nv8B-2pbyA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		5 / 12 ILE A  44
GLY A 275
GLY A 209
VAL A 270
PRO A  47
 None
 1.01A 1sg9B-2pbyA:
undetectable		 1sg9B-2pbyA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		5 / 6 VAL A  51
VAL A 142
ILE A  66
ILE A 198
ASP A 204
 None
 1.44A 1uwhB-2pbyA:
undetectable		 1uwhB-2pbyA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A 242
ILE A 115
ALA A 119
ILE A  66
SER A  65
 None
 1.09A 1ve3B-2pbyA:
undetectable		 1ve3B-2pbyA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		4 / 4 LEU A 145
LEU A  63
SER A  67
LEU A 138
 None
 1.19A 1ya3A-2pbyA:
undetectable		 1ya3A-2pbyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		5 / 12 ALA A 258
GLY A 277
LEU A 296
SER A 300
LEU A 295
 None
 1.01A 1ya4A-2pbyA:
undetectable		 1ya4A-2pbyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		5 / 5 LEU A 290
ASP A 284
GLY A 261
PRO A 281
ALA A 282
 None
 1.36A 2aohA-2pbyA:
undetectable		 2aohA-2pbyA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		5 / 12 ALA A 213
GLY A 272
LEU A 212
VAL A 239
THR A 240
 None
 1.05A 2nyuB-2pbyA:
undetectable		 2nyuB-2pbyA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		3 / 3 PRO A 257
PHE A 237
LYS A 259
 None
 1.28A 3bjwG-2pbyA:
undetectable		 3bjwG-2pbyA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		5 / 11 GLU A  39
GLY A  55
ILE A  42
PHE A 279
ALA A  43
 None
 1.24A 3nmuB-2pbyA:
undetectable
3nmuJ-2pbyA:
undetectable		 3nmuB-2pbyA:
23.33
3nmuJ-2pbyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A  55
ILE A  42
PHE A 279
ALA A  43
VAL A  57
 None
 1.15A 3nvkI-2pbyA:
undetectable		 3nvkI-2pbyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		5 / 8 ALA A 158
VAL A 157
LEU A  32
LEU A  63
THR A  62
 None
 1.31A 3roxA-2pbyA:
undetectable		 3roxA-2pbyA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A 292
GLY A 280
ILE A  42
SER A  41
ALA A  16
 None
 1.12A 4qtuB-2pbyA:
undetectable		 4qtuB-2pbyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		5 / 12 ASN A 245
GLY A 242
TYR A 244
ILE A  69
ILE A  66
 None
 1.30A 4xucA-2pbyA:
undetectable		 4xucA-2pbyA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		4 / 8 GLY A 265
ILE A 256
GLY A 277
PHE A 279
 None
 0.80A 5alcL-2pbyA:
undetectable		 5alcL-2pbyA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		4 / 4 GLN A 195
THR A 193
LEU A 171
LEU A 120
 None
 1.09A 5m5kB-2pbyA:
undetectable		 5m5kB-2pbyA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2pby GLUTAMINASE
(Geobacillus
kaustophilus) 		5 / 12 GLU A  83
VAL A  84
LEU A 191
PRO A 113
GLY A 118
 None
 1.24A 5syeB-2pbyA:
undetectable		 5syeB-2pbyA:
21.09