SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pbz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 2pbz HYPOTHETICAL PROTEIN
(Thermococcus
kodakarensis) 		4 / 5 SER A   6
ASN A  59
ALA A  84
ASP A  61
 None
 1.16A 1lqtA-2pbzA:
3.9
1lqtB-2pbzA:
undetectable		 1lqtA-2pbzA:
22.31
1lqtB-2pbzA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 2pbz HYPOTHETICAL PROTEIN
(Thermococcus
kodakarensis) 		4 / 5 SER A   6
ASN A  59
ALA A  84
ASP A  61
 None
 1.16A 1lquA-2pbzA:
3.9
1lquB-2pbzA:
undetectable		 1lquA-2pbzA:
22.31
1lquB-2pbzA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 2pbz HYPOTHETICAL PROTEIN
(Thermococcus
kodakarensis) 		4 / 6 ASN A 214
HIS A 253
TYR A 172
GLY A 271
 None
None
ATP  A 400 (-4.7A)
None
 1.24A 1mxdA-2pbzA:
undetectable		 1mxdA-2pbzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 2pbz HYPOTHETICAL PROTEIN
(Thermococcus
kodakarensis) 		4 / 7 ASN A 214
HIS A 253
TYR A 172
GLY A 271
 None
None
ATP  A 400 (-4.7A)
None
 1.21A 1mxgA-2pbzA:
undetectable		 1mxgA-2pbzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2pbz HYPOTHETICAL PROTEIN
(Thermococcus
kodakarensis) 		4 / 7 PHE A 176
GLU A 182
ARG A 293
VAL A 310
 None
 1.41A 3nlnA-2pbzA:
undetectable
3nlnB-2pbzA:
undetectable		 3nlnA-2pbzA:
22.25
3nlnB-2pbzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2pbz HYPOTHETICAL PROTEIN
(Thermococcus
kodakarensis) 		4 / 7 SER A  56
LEU A  74
VAL A  64
SER A   6
 None
 1.00A 3r9vA-2pbzA:
undetectable
3r9vB-2pbzA:
undetectable		 3r9vA-2pbzA:
21.47
3r9vB-2pbzA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 2pbz HYPOTHETICAL PROTEIN
(Thermococcus
kodakarensis) 		5 / 11 ILE A 247
ILE A 294
PHE A 176
ALA A 295
GLU A 302
 None
 1.11A 3tmzA-2pbzA:
undetectable		 3tmzA-2pbzA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2pbz HYPOTHETICAL PROTEIN
(Thermococcus
kodakarensis) 		4 / 6 ARG A 293
VAL A 310
PHE A 176
GLU A 182
 None
 1.36A 3ufrA-2pbzA:
undetectable
3ufrB-2pbzA:
undetectable		 3ufrA-2pbzA:
22.25
3ufrB-2pbzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 2pbz HYPOTHETICAL PROTEIN
(Thermococcus
kodakarensis) 		4 / 5 ASP A 190
GLY A 213
TYR A 172
ASP A 270
 None
None
ATP  A 400 (-4.7A)
None
 1.21A 3w9tD-2pbzA:
undetectable		 3w9tD-2pbzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 2pbz HYPOTHETICAL PROTEIN
(Thermococcus
kodakarensis) 		3 / 3 PRO A 179
TYR A 177
GLY A 248
 None
 0.72A 4g2zA-2pbzA:
undetectable		 4g2zA-2pbzA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 2pbz HYPOTHETICAL PROTEIN
(Thermococcus
kodakarensis) 		5 / 8 ALA A 295
GLU A 302
VAL A  65
PRO A  66
VAL A 311
 None
 1.32A 4jltA-2pbzA:
undetectable		 4jltA-2pbzA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 2pbz HYPOTHETICAL PROTEIN
(Thermococcus
kodakarensis) 		5 / 12 GLY A  19
GLN A  15
ALA A 295
LEU A 288
SER A 273
 None
 1.20A 4pd9A-2pbzA:
undetectable		 4pd9A-2pbzA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 2pbz HYPOTHETICAL PROTEIN
(Thermococcus
kodakarensis) 		4 / 5 LEU A 224
TYR A 279
ALA A 218
ILE A 217
 None
 1.06A 4y03B-2pbzA:
undetectable		 4y03B-2pbzA:
16.83