SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pc6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2pc6 PROBABLE
ACETOLACTATE
SYNTHASE ISOZYME III
(SMALL SUBUNIT)
(Nitrosomonas
europaea) 		3 / 3 PHE A  23
LEU A  64
LEU A   7
 None
 0.66A 1mx1E-2pc6A:
undetectable		 1mx1E-2pc6A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 2pc6 PROBABLE
ACETOLACTATE
SYNTHASE ISOZYME III
(SMALL SUBUNIT)
(Nitrosomonas
europaea) 		4 / 7 GLY A  52
THR A  50
MET A   1
SER A  77
 None
 1.07A 2o5yH-2pc6A:
undetectable
2o5yL-2pc6A:
undetectable		 2o5yH-2pc6A:
19.81
2o5yL-2pc6A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 2pc6 PROBABLE
ACETOLACTATE
SYNTHASE ISOZYME III
(SMALL SUBUNIT)
(Nitrosomonas
europaea) 		5 / 12 LEU A 144
VAL A 115
ALA A 105
LEU A 104
PHE A 134
 None
 1.09A 2oz7A-2pc6A:
undetectable		 2oz7A-2pc6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 2pc6 PROBABLE
ACETOLACTATE
SYNTHASE ISOZYME III
(SMALL SUBUNIT)
(Nitrosomonas
europaea) 		3 / 3 ARG A 156
ILE A   4
THR A 149
 None
 0.64A 3ia4D-2pc6A:
undetectable		 3ia4D-2pc6A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 2pc6 PROBABLE
ACETOLACTATE
SYNTHASE ISOZYME III
(SMALL SUBUNIT)
(Nitrosomonas
europaea) 		4 / 6 GLU A  85
ARG A 148
LEU A 124
ARG A  84
 None
 1.27A 5l6eA-2pc6A:
undetectable
5l6eB-2pc6A:
undetectable		 5l6eA-2pc6A:
22.36
5l6eB-2pc6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2pc6 PROBABLE
ACETOLACTATE
SYNTHASE ISOZYME III
(SMALL SUBUNIT)
(Nitrosomonas
europaea) 		3 / 3 LEU A  22
SER A  24
PHE A  23
 None
 0.63A 6fgcA-2pc6A:
undetectable		 6fgcA-2pc6A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2pc6 PROBABLE
ACETOLACTATE
SYNTHASE ISOZYME III
(SMALL SUBUNIT)
(Nitrosomonas
europaea) 		5 / 10 ALA A  15
LEU A  16
VAL A  19
ILE A   5
LEU A   7
 None
 0.87A 6h1lA-2pc6A:
undetectable		 6h1lA-2pc6A:
15.40