SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pce'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		3 / 3 LEU A 215
PRO A 216
LEU A 219
 None
 0.55A 1hrkA-2pceA:
3.4		 1hrkA-2pceA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 8 GLY A 161
TYR A 195
SER A 137
HIS A 154
 None
 1.05A 1maaD-2pceA:
undetectable		 1maaD-2pceA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 8 TYR A  28
THR A 300
TYR A  57
LEU A 326
 None
 1.41A 1uw6A-2pceA:
undetectable
1uw6B-2pceA:
undetectable		 1uw6A-2pceA:
18.95
1uw6B-2pceA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 8 TYR A  28
THR A 300
TYR A  57
LEU A 326
 None
 1.42A 1uw6D-2pceA:
undetectable
1uw6E-2pceA:
undetectable		 1uw6D-2pceA:
18.95
1uw6E-2pceA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 8 TYR A  28
THR A 300
TYR A  57
LEU A 326
 None
 1.42A 1uw6G-2pceA:
undetectable
1uw6H-2pceA:
undetectable		 1uw6G-2pceA:
18.95
1uw6H-2pceA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 8 TYR A  28
THR A 300
TYR A  57
LEU A 326
 None
 1.42A 1uw6P-2pceA:
undetectable
1uw6Q-2pceA:
undetectable		 1uw6P-2pceA:
18.95
1uw6Q-2pceA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 8 LEU A 326
TYR A  28
THR A 300
TYR A  57
 None
 1.38A 1uw6P-2pceA:
undetectable
1uw6T-2pceA:
undetectable		 1uw6P-2pceA:
18.95
1uw6T-2pceA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		5 / 9 THR A 125
LEU A 282
ALA A 309
LEU A 356
GLU A  49
 None
 1.37A 2azqA-2pceA:
undetectable		 2azqA-2pceA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 6 THR A  65
SER A 273
ASP A 100
VAL A 301
 None
 1.29A 2hdnI-2pceA:
undetectable
2hdnJ-2pceA:
2.0
2hdnL-2pceA:
2.3		 2hdnI-2pceA:
7.87
2hdnJ-2pceA:
21.67
2hdnL-2pceA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 6 VAL A 301
THR A  65
SER A 273
ASP A 100
 None
 1.20A 2hdnJ-2pceA:
2.0
2hdnK-2pceA:
undetectable
2hdnL-2pceA:
2.2		 2hdnJ-2pceA:
21.67
2hdnK-2pceA:
7.87
2hdnL-2pceA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 5 LEU A 215
PRO A 216
LEU A 219
ILE A 221
 None
 0.52A 2qd4A-2pceA:
3.4		 2qd4A-2pceA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		5 / 12 LEU A 121
ILE A 310
ALA A 314
THR A 317
ARG A 283
 None
 1.05A 2v0mC-2pceA:
undetectable		 2v0mC-2pceA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 8 ALA A 337
ILE A 339
ILE A 305
HIS A 312
 None
 0.73A 2zm8A-2pceA:
undetectable		 2zm8A-2pceA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 8 ALA A 337
ILE A 339
ILE A 305
HIS A 312
 None
 0.74A 2zmaA-2pceA:
undetectable		 2zmaA-2pceA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		5 / 12 GLN A 275
ASP A 255
ASP A 247
GLU A 248
ILE A  58
 None
 1.42A 3b7pC-2pceA:
undetectable		 3b7pC-2pceA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		5 / 12 LEU A 121
LEU A 313
ALA A 309
ILE A 112
GLY A  46
 None
 1.01A 3q95B-2pceA:
undetectable		 3q95B-2pceA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		3 / 3 ASP A  41
ARG A  82
LYS A   1
 None
 1.09A 3wipG-2pceA:
undetectable		 3wipG-2pceA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 4 LEU A 215
PRO A 216
LEU A 219
ILE A 221
 None
 0.68A 4f4dB-2pceA:
undetectable		 4f4dB-2pceA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 7 VAL A 360
SER A 303
LEU A 356
ASP A 111
 None
 1.00A 4hxyB-2pceA:
undetectable		 4hxyB-2pceA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		5 / 11 GLY A 174
GLY A 173
ALA A 176
LEU A 177
GLU A 180
 None
 0.77A 4l8fB-2pceA:
undetectable		 4l8fB-2pceA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		5 / 11 GLY A 174
GLY A 173
ALA A 176
LEU A 177
GLU A 180
 None
 0.80A 4l8fD-2pceA:
undetectable		 4l8fD-2pceA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		3 / 3 GLY A 174
PRO A 175
ALA A 208
 None
 0.55A 4qn9B-2pceA:
undetectable		 4qn9B-2pceA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		5 / 11 ASP A 100
ALA A 108
VAL A  36
SER A  50
GLY A  48
 None
 1.16A 4xnxA-2pceA:
undetectable		 4xnxA-2pceA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		5 / 10 SER A  50
LEU A 121
LEU A 313
SER A 273
LEU A 282
 None
 1.12A 4yiaA-2pceA:
undetectable		 4yiaA-2pceA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 5 ALA A 176
ARG A 210
ALA A 168
GLU A 170
 None
 1.03A 5a06C-2pceA:
undetectable
5a06D-2pceA:
2.1		 5a06C-2pceA:
24.29
5a06D-2pceA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 7 VAL A 272
SER A 273
ALA A 103
GLY A  48
 None
 0.87A 5fpdA-2pceA:
2.5		 5fpdA-2pceA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 7 VAL A 272
SER A 273
ALA A 103
GLY A  48
 None
 0.86A 5fpdB-2pceA:
undetectable		 5fpdB-2pceA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		5 / 12 PHE A  53
GLY A 277
GLY A 302
SER A 306
LEU A 356
 None
 0.87A 5gwxA-2pceA:
undetectable		 5gwxA-2pceA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		4 / 5 SER A 273
VAL A 272
GLY A 277
ALA A 103
 None
 1.09A 5k50A-2pceA:
undetectable		 5k50A-2pceA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Roseovarius
nubinhibens) 		3 / 3 SER A 138
SER A 163
PHE A  53
 None
 0.90A 5mugA-2pceA:
1.8		 5mugA-2pceA:
18.46