SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pcl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		6 / 11 ARG A 208
LEU A 210
VAL A 196
GLY A  51
VAL A  33
ILE A  35
 None
 1.29A 1t3rB-2pclA:
undetectable		 1t3rB-2pclA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		4 / 4 LEU A 130
ILE A 182
ILE A 151
ALA A 150
 None
EDO  A 235 ( 4.9A)
None
None
 0.85A 2i30A-2pclA:
undetectable		 2i30A-2pclA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		3 / 3 ILE A 193
ILE A 151
LEU A  63
 None
 0.57A 2prgA-2pclA:
undetectable		 2prgA-2pclA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		6 / 12 ARG A 208
LEU A 210
VAL A 196
GLY A  51
VAL A  33
ILE A  35
 None
 1.31A 2q64B-2pclA:
undetectable		 2q64B-2pclA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		6 / 12 ARG A 208
LEU A 210
VAL A 196
GLY A  51
VAL A  33
ILE A  35
 None
 1.31A 3bvbA-2pclA:
undetectable		 3bvbA-2pclA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		4 / 4 ILE A 151
GLN A 147
VAL A  87
PHE A 183
 None
 1.10A 3ieoA-2pclA:
0.0		 3ieoA-2pclA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		5 / 12 ILE A 193
ARG A 153
LEU A 155
ILE A 182
LEU A 128
 None
None
None
EDO  A 235 ( 4.9A)
None
 0.91A 3k2hB-2pclA:
undetectable		 3k2hB-2pclA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		5 / 12 LEU A 210
VAL A 196
GLY A  51
VAL A  33
ILE A  35
 None
 1.02A 3pwmA-2pclA:
undetectable		 3pwmA-2pclA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		5 / 11 ALA A 203
ILE A  35
ILE A 193
PRO A 167
THR A 168
 None
None
None
MG  A 225 ( 3.8A)
MG  A 225 ( 3.3A)
 1.14A 3spkA-2pclA:
undetectable		 3spkA-2pclA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		6 / 11 ARG A 208
LEU A 210
VAL A 196
GLY A  51
VAL A  33
ILE A  35
 None
 1.30A 4dqeA-2pclA:
undetectable		 4dqeA-2pclA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		6 / 11 ARG A 208
LEU A 210
VAL A 196
GLY A  51
VAL A  33
ILE A  35
 None
 1.25A 4dqhA-2pclA:
undetectable		 4dqhA-2pclA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		5 / 12 ILE A  23
GLY A  37
ALA A  38
SER A  41
GLY A 215
 None
None
None
SO4  A 226 ( 2.8A)
None
 1.06A 4e1gA-2pclA:
undetectable		 4e1gA-2pclA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		5 / 12 ILE A  23
GLY A  37
ALA A  38
SER A  41
GLY A 215
 None
None
None
SO4  A 226 ( 2.8A)
None
 1.07A 4e1gB-2pclA:
2.3		 4e1gB-2pclA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		4 / 7 GLY A 144
GLN A 147
ASN A 175
HIS A  91
 None
None
SO4  A 227 ( 3.4A)
SO4  A 230 ( 3.8A)
 1.12A 4ws0A-2pclA:
undetectable		 4ws0A-2pclA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		5 / 12 LEU A 210
VAL A 196
GLY A  51
VAL A  33
ILE A  35
 None
 1.00A 5kqyA-2pclA:
undetectable		 5kqyA-2pclA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		5 / 10 ASP A 165
LEU A  93
ALA A 150
GLY A 169
LEU A 171
 None
 1.24A 5m5cE-2pclA:
undetectable		 5m5cE-2pclA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		5 / 12 ASN A  72
GLU A  73
GLU A  75
LEU A  76
LEU A  79
 None
EDO  A 232 ( 4.5A)
None
EDO  A 233 ( 4.9A)
EDO  A 233 ( 4.1A)
 1.32A 5nwvA-2pclA:
undetectable		 5nwvA-2pclA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD
(Aquifex
aeolicus) 		5 / 10 LEU A  50
LEU A  63
ILE A  10
PRO A  56
GLY A  59
 None
 1.31A 6dm0B-2pclA:
2.3
6dm0C-2pclA:
undetectable		 6dm0B-2pclA:
17.59
6dm0C-2pclA:
17.59