SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pcn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2pcn S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Geobacillus
kaustophilus) 		4 / 6 VAL A  90
GLY A  89
LEU A  87
GLU A  53
 None
 0.94A 1fduD-2pcnA:
undetectable		 1fduD-2pcnA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2pcn S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Geobacillus
kaustophilus) 		4 / 8 ALA A  82
GLY A  27
ALA A  79
ILE A 102
 None
 0.72A 1gtnI-2pcnA:
undetectable
1gtnJ-2pcnA:
undetectable		 1gtnI-2pcnA:
18.90
1gtnJ-2pcnA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 2pcn S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Geobacillus
kaustophilus) 		5 / 12 ILE A 102
LEU A  52
GLY A 103
GLY A  27
LEU A  74
 None
 1.04A 1liiA-2pcnA:
undetectable		 1liiA-2pcnA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2pcn S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Geobacillus
kaustophilus) 		5 / 12 GLU A 101
TYR A  26
CYH A  83
ALA A  79
ALA A  82
 None
 1.18A 2bm9D-2pcnA:
undetectable		 2bm9D-2pcnA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 2pcn S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Geobacillus
kaustophilus) 		4 / 8 ILE A 112
PHE A  23
LEU A  21
PHE A 133
 None
 0.90A 2vdbA-2pcnA:
undetectable		 2vdbA-2pcnA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2pcn S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Geobacillus
kaustophilus) 		4 / 8 LEU A  52
LEU A  61
VAL A  90
ILE A  92
 None
 0.86A 4oj4A-2pcnA:
undetectable		 4oj4A-2pcnA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 2pcn S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Geobacillus
kaustophilus) 		5 / 12 VAL A  62
ILE A  96
ILE A 102
PHE A  32
ILE A  81
 None
 1.12A 5hw8B-2pcnA:
undetectable
5hw8F-2pcnA:
undetectable
5hw8G-2pcnA:
undetectable		 5hw8B-2pcnA:
22.70
5hw8F-2pcnA:
22.70
5hw8G-2pcnA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2pcn S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Geobacillus
kaustophilus) 		4 / 7 GLY A  75
VAL A  90
ILE A 107
VAL A 109
 ACT  A 600 ( 4.4A)
None
None
None
 0.80A 5ik1A-2pcnA:
undetectable		 5ik1A-2pcnA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2pcn S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Geobacillus
kaustophilus) 		4 / 7 ALA A 111
ASP A  76
ILE A 102
ILE A 107
 None
 0.88A 6fbnA-2pcnA:
undetectable		 6fbnA-2pcnA:
19.11