SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pcq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLU A  83
ALA A  86
MET A 119
LEU A  92
GLU A  71
 None
 1.20A 1a29A-2pcqA:
undetectable		 1a29A-2pcqA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 8 ALA A 219
LEU A 208
LEU A 207
LEU A 182
 None
 0.74A 1e7cA-2pcqA:
undetectable		 1e7cA-2pcqA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A   3
GLY A  34
VAL A  67
ALA A  25
LEU A  24
 None
 1.17A 1gs4A-2pcqA:
undetectable		 1gs4A-2pcqA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 11 ALA A  94
VAL A 139
LEU A 142
ALA A 143
LEU A 121
 None
 0.99A 1jinA-2pcqA:
undetectable		 1jinA-2pcqA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 8 SER A 263
PHE A 269
LEU A 229
LEU A 248
 None
 0.99A 2bfpA-2pcqA:
1.6		 2bfpA-2pcqA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 8 SER A 263
PHE A 269
LEU A 229
LEU A 248
 None
 0.98A 2bfpB-2pcqA:
undetectable		 2bfpB-2pcqA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		3 / 3 ALA A 184
THR A 175
PHE A 211
 None
 0.61A 2c6nB-2pcqA:
undetectable		 2c6nB-2pcqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLY A 230
LEU A 199
ALA A 244
LEU A 240
LEU A 265
 None
 1.01A 2yqzA-2pcqA:
undetectable		 2yqzA-2pcqA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 PRO A   5
LEU A 241
ALA A 196
PRO A   4
 None
 1.20A 3gv1A-2pcqA:
undetectable
3gv1C-2pcqA:
undetectable		 3gv1A-2pcqA:
18.12
3gv1C-2pcqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 LEU A 241
ALA A 196
PRO A   4
PRO A   5
 None
 1.23A 3gv1A-2pcqA:
undetectable
3gv1B-2pcqA:
undetectable		 3gv1A-2pcqA:
18.12
3gv1B-2pcqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 LEU A  35
GLN A  26
LEU A  28
GLU A  29
 None
 1.05A 3h5gB-2pcqA:
undetectable
3h5gC-2pcqA:
undetectable		 3h5gB-2pcqA:
8.19
3h5gC-2pcqA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 ARG A  52
GLY A  68
PHE A 122
LEU A  66
GLU A  71
 None
 1.12A 3kkzA-2pcqA:
undetectable		 3kkzA-2pcqA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  36
ALA A  84
GLY A  68
LEU A  92
ALA A  86
 None
 1.01A 3ou6A-2pcqA:
undetectable		 3ou6A-2pcqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  36
ALA A  84
GLY A  68
LEU A  92
ALA A  86
 None
 1.03A 3ou6B-2pcqA:
undetectable		 3ou6B-2pcqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  36
GLU A  83
GLY A  68
LEU A  92
ALA A  86
 None
 1.25A 3ou6C-2pcqA:
undetectable		 3ou6C-2pcqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  36
GLU A  83
ALA A  84
GLY A  68
LEU A  92
 None
 1.34A 3ou6D-2pcqA:
undetectable		 3ou6D-2pcqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		6 / 12 GLY A  68
GLY A  39
VAL A  45
ALA A  80
LEU A  66
LEU A  69
 None
 1.36A 3p2kC-2pcqA:
undetectable		 3p2kC-2pcqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		6 / 12 GLY A  68
GLY A  39
VAL A  45
ALA A  80
LEU A  66
LEU A  69
 None
 1.35A 3p2kD-2pcqA:
undetectable		 3p2kD-2pcqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A 134
GLY A 188
LEU A 123
HIS A 125
ASP A 153
 None
 0.95A 4blvA-2pcqA:
undetectable		 4blvA-2pcqA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		6 / 12 SER A  40
GLY A  39
GLY A 192
GLY A 176
THR A 175
ILE A   2
 None
 1.30A 4ctkC-2pcqA:
undetectable		 4ctkC-2pcqA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 10 LEU A 229
LEU A 233
ASN A 198
LEU A  28
LEU A 250
 None
 1.09A 4po0A-2pcqA:
undetectable		 4po0A-2pcqA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 LEU A 245
LEU A 240
PHE A 269
VAL A 282
 None
 1.09A 4udaA-2pcqA:
undetectable		 4udaA-2pcqA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 8 GLU A  29
ASP A  33
ARG A 205
PRO A  30
 None
 1.18A 4uhxA-2pcqA:
undetectable		 4uhxA-2pcqA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 8 GLU A  29
ASP A  33
ARG A 205
PRO A  30
 None
 1.18A 4uhxA-2pcqA:
undetectable		 4uhxA-2pcqA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 8 ALA A  89
VAL A  67
PHE A  65
GLY A  88
ALA A  86
 None
 1.42A 4zjzB-2pcqA:
undetectable		 4zjzB-2pcqA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 ILE A 151
GLY A 150
TYR A 164
ASP A 133
TYR A 112
 None
 1.26A 5igvA-2pcqA:
undetectable		 5igvA-2pcqA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 LEU A  81
LEU A  92
LEU A 123
GLU A 113
 None
 0.96A 5tudD-2pcqA:
undetectable		 5tudD-2pcqA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLU A  19
PRO A   9
THR A   8
GLU A  43
THR A  48
 None
 1.35A 5xioB-2pcqA:
undetectable		 5xioB-2pcqA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
LEU A 245
ALA A 244
GLY A 230
LEU A 229
 None
 1.03A 6b0iB-2pcqA:
undetectable		 6b0iB-2pcqA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 4 LYS A  85
LEU A  81
ALA A  84
LEU A  69
 None
 1.45A 6gnrA-2pcqA:
undetectable		 6gnrA-2pcqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 4 LYS A 118
LEU A  81
ALA A 116
LEU A  92
 None
 1.45A 6gnrA-2pcqA:
undetectable		 6gnrA-2pcqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 4 LYS A  85
LEU A  81
ALA A  84
LEU A  69
 None
 1.42A 6gnrB-2pcqA:
undetectable		 6gnrB-2pcqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 4 LYS A 118
LEU A  81
ALA A 116
LEU A  92
 None
 1.44A 6gnrB-2pcqA:
undetectable		 6gnrB-2pcqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 7 GLY A  39
TYR A  38
GLU A  18
GLY A  55
 None
 0.92A 6n7fA-2pcqA:
undetectable		 6n7fA-2pcqA:
13.98