SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pcr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 2pcr INOSITOL-1-MONOPHOSP
HATASE
(Aquifex
aeolicus) 		5 / 12 GLY A 244
ALA A 243
ILE A 215
GLY A 218
ILE A 221
 None
 1.07A 1c6zA-2pcrA:
undetectable		 1c6zA-2pcrA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 2pcr INOSITOL-1-MONOPHOSP
HATASE
(Aquifex
aeolicus) 		5 / 11 GLY A 244
ALA A 243
ILE A 215
GLY A 218
ILE A 221
 None
 0.82A 1n49B-2pcrA:
undetectable		 1n49B-2pcrA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 2pcr INOSITOL-1-MONOPHOSP
HATASE
(Aquifex
aeolicus) 		5 / 11 GLY A 244
ALA A 243
ILE A 215
GLY A 218
ILE A 221
 None
 0.82A 1n49C-2pcrA:
undetectable		 1n49C-2pcrA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2pcr INOSITOL-1-MONOPHOSP
HATASE
(Aquifex
aeolicus) 		4 / 6 PHE A  98
ASN A  96
ASN A  93
GLY A 188
 None
 1.08A 1oniA-2pcrA:
undetectable
1oniB-2pcrA:
undetectable		 1oniA-2pcrA:
21.01
1oniB-2pcrA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2pcr INOSITOL-1-MONOPHOSP
HATASE
(Aquifex
aeolicus) 		4 / 6 PHE A  98
ASN A  96
ASN A  93
GLY A 188
 None
 1.06A 1oniD-2pcrA:
undetectable
1oniF-2pcrA:
undetectable		 1oniD-2pcrA:
21.01
1oniF-2pcrA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2pcr INOSITOL-1-MONOPHOSP
HATASE
(Aquifex
aeolicus) 		5 / 8 ASP A  89
ALA A 190
ASP A 193
ILE A 215
ILE A 241
 None
 1.22A 1sh9A-2pcrA:
undetectable		 1sh9A-2pcrA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 2pcr INOSITOL-1-MONOPHOSP
HATASE
(Aquifex
aeolicus) 		5 / 9 ARG A  82
ILE A 221
ILE A 215
PRO A 113
VAL A 108
 None
 1.11A 2avoA-2pcrA:
undetectable		 2avoA-2pcrA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 2pcr INOSITOL-1-MONOPHOSP
HATASE
(Aquifex
aeolicus) 		5 / 11 ARG A  82
ILE A 221
ILE A 215
PRO A 113
VAL A 108
 None
 0.84A 2nnpB-2pcrA:
undetectable		 2nnpB-2pcrA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 2pcr INOSITOL-1-MONOPHOSP
HATASE
(Aquifex
aeolicus) 		5 / 12 GLY A 244
ALA A 243
ILE A 215
GLY A 218
ILE A 221
 None
 0.99A 3d1xB-2pcrA:
undetectable		 3d1xB-2pcrA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 2pcr INOSITOL-1-MONOPHOSP
HATASE
(Aquifex
aeolicus) 		5 / 12 GLY A 244
ALA A 243
ILE A 215
GLY A 218
ILE A 221
 None
 1.08A 3ndxA-2pcrA:
undetectable		 3ndxA-2pcrA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2pcr INOSITOL-1-MONOPHOSP
HATASE
(Aquifex
aeolicus) 		4 / 8 VAL A 192
ASP A 193
GLY A 188
ALA A 102
 None
 0.91A 4m48A-2pcrA:
undetectable		 4m48A-2pcrA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 2pcr INOSITOL-1-MONOPHOSP
HATASE
(Aquifex
aeolicus) 		5 / 12 GLY A 244
ALA A 243
ILE A 215
GLY A 218
ILE A 221
 None
 1.13A 4njvD-2pcrA:
undetectable		 4njvD-2pcrA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2pcr INOSITOL-1-MONOPHOSP
HATASE
(Aquifex
aeolicus) 		5 / 12 TYR A 127
ALA A 102
ILE A 100
ASN A  93
GLY A  90
 None
 1.09A 4obwD-2pcrA:
undetectable		 4obwD-2pcrA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 2pcr INOSITOL-1-MONOPHOSP
HATASE
(Aquifex
aeolicus) 		5 / 9 ARG A  82
GLY A 218
ILE A 215
PRO A 113
VAL A 108
 None
 1.02A 5kr2D-2pcrA:
undetectable		 5kr2D-2pcrA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 2pcr INOSITOL-1-MONOPHOSP
HATASE
(Aquifex
aeolicus) 		5 / 9 ARG A  82
ILE A 221
ILE A 215
PRO A 113
VAL A 108
 None
 1.02A 5kr2D-2pcrA:
undetectable		 5kr2D-2pcrA:
19.70