SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pcs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2pcs CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		5 / 12 TYR A  74
LEU A  26
ILE A  93
PHE A 136
ILE A  30
 UNL  A 161 (-4.3A)
UNL  A 161 (-3.9A)
None
UNL  A 161 (-4.2A)
UNL  A 161 ( 4.7A)
 1.35A 1xotA-2pcsA:
undetectable		 1xotA-2pcsA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 2pcs CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		4 / 8 VAL A 117
ILE A  50
TYR A  59
GLY A  85
 UNL  A 161 ( 4.9A)
UNL  A 161 ( 4.8A)
UNL  A 161 ( 3.9A)
None
 0.97A 3n9jA-2pcsA:
undetectable		 3n9jA-2pcsA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 2pcs CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		3 / 3 TYR A 107
MET A  31
LEU A 131
 UNL  A 161 ( 4.8A)
None
None
 1.01A 3vw1D-2pcsA:
undetectable		 3vw1D-2pcsA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2pcs CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		5 / 10 GLY A 114
ALA A 111
VAL A 113
GLU A 112
VAL A 117
 None
UNL  A 161 ( 4.9A)
None
None
UNL  A 161 ( 4.9A)
 1.15A 4da7A-2pcsA:
undetectable		 4da7A-2pcsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2pcs CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		4 / 7 GLY A   3
GLY A   5
SER A   6
LYS A 130
 None
 0.75A 5izfA-2pcsA:
undetectable		 5izfA-2pcsA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2pcs CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		5 / 12 GLY A 121
GLY A  51
ILE A  50
GLY A 127
GLY A 126
 None
None
UNL  A 161 ( 4.8A)
None
None
 0.89A 5koxA-2pcsA:
undetectable		 5koxA-2pcsA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2pcs CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		5 / 12 PHE A 136
PHE A 137
LEU A  20
LEU A  76
TYR A  74
 UNL  A 161 (-4.2A)
UNL  A 161 ( 4.9A)
UNL  A 161 (-4.7A)
UNL  A 161 (-4.8A)
UNL  A 161 (-4.3A)
 1.30A 5y2oA-2pcsA:
undetectable		 5y2oA-2pcsA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2pcs CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		3 / 3 PHE A 136
ASP A 135
LYS A 139
 UNL  A 161 (-4.2A)
None
None
 0.79A 6awtD-2pcsA:
13.4		 6awtD-2pcsA:
27.01