SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pcu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 7 PHE A 106
ALA A  61
ILE A 183
ILE A 263
 None
 0.98A 1oniD-2pcuA:
undetectable
1oniF-2pcuA:
undetectable		 1oniD-2pcuA:
17.16
1oniF-2pcuA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 7 SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
ZN  A 999 (-4.6A)
 1.21A 2c8aA-2pcuA:
undetectable		 2c8aA-2pcuA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 7 GLY A 278
SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
None
ZN  A 999 (-4.6A)
 1.30A 2c8aB-2pcuA:
undetectable		 2c8aB-2pcuA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 6 SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
ZN  A 999 (-4.6A)
 1.26A 2c8aC-2pcuA:
undetectable		 2c8aC-2pcuA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 ALA A  66
ASN A  65
ILE A 193
ASP A 194
 None
 0.99A 2h4jA-2pcuA:
undetectable		 2h4jA-2pcuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 SER A 197
LEU A 280
GLY A 278
ARG A 124
 None
GOL  A 501 (-4.4A)
None
GOL  A 501 (-4.0A)
 0.93A 2j2pA-2pcuA:
undetectable
2j2pB-2pcuA:
undetectable		 2j2pA-2pcuA:
21.32
2j2pB-2pcuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 6 ARG A 124
SER A 197
LEU A 280
GLY A 278
 GOL  A 501 (-4.0A)
None
GOL  A 501 (-4.4A)
None
 1.03A 2j2pA-2pcuA:
undetectable
2j2pC-2pcuA:
undetectable		 2j2pA-2pcuA:
21.32
2j2pC-2pcuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 6 ARG A 124
SER A 197
LEU A 280
GLY A 278
 GOL  A 501 (-4.0A)
None
GOL  A 501 (-4.4A)
None
 1.00A 2j2pD-2pcuA:
undetectable
2j2pF-2pcuA:
undetectable		 2j2pD-2pcuA:
21.32
2j2pF-2pcuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		3 / 3 GLU A 270
HIS A  69
GLU A  72
 ZN  A 999 (-4.6A)
ZN  A 999 ( 3.1A)
ZN  A 999 (-2.1A)
 0.79A 2x45B-2pcuA:
undetectable		 2x45B-2pcuA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		3 / 3 GLU A 270
HIS A  69
GLU A  72
 ZN  A 999 (-4.6A)
ZN  A 999 ( 3.1A)
ZN  A 999 (-2.1A)
 0.81A 2x45C-2pcuA:
undetectable		 2x45C-2pcuA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 8 LEU A  64
ILE A 193
LEU A 297
THR A  82
LEU A 107
 None
 1.46A 2xfhA-2pcuA:
undetectable		 2xfhA-2pcuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 12 SER A  70
ASN A 112
THR A 119
VAL A 117
SER A  41
 None
 1.37A 2xpvA-2pcuA:
0.6		 2xpvA-2pcuA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 7 VAL A 176
ILE A 183
GLN A 184
GLY A 187
 None
 0.87A 3bjwB-2pcuA:
undetectable		 3bjwB-2pcuA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 6 THR A 289
THR A 293
LEU A 195
THR A  78
 None
 0.65A 3deuB-2pcuA:
1.5		 3deuB-2pcuA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 7 ILE A 255
GLY A 252
TYR A 248
VAL A 247
ARG A 127
 None
None
None
None
ZN  A 999 (-4.5A)
 1.00A 3elzA-2pcuA:
undetectable		 3elzA-2pcuA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 10 ILE A 255
GLY A 252
TYR A 248
VAL A 247
ARG A 127
 None
None
None
None
ZN  A 999 (-4.5A)
 0.97A 3elzC-2pcuA:
undetectable		 3elzC-2pcuA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 7 LEU A 195
LEU A 107
VAL A  87
SER A  88
 None
 0.94A 3r9vA-2pcuA:
undetectable
3r9vB-2pcuA:
undetectable		 3r9vA-2pcuA:
19.69
3r9vB-2pcuA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 THR A 129
GLY A 115
PRO A 113
ASN A 112
 None
 0.86A 3u8qA-2pcuA:
undetectable		 3u8qA-2pcuA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 GLU A 237
GLY A 235
TYR A 238
GLU A 292
 None
 1.32A 3w9tA-2pcuA:
undetectable		 3w9tA-2pcuA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 GLU A 237
GLY A 235
TYR A 238
GLU A 292
 None
 1.31A 3w9tC-2pcuA:
undetectable		 3w9tC-2pcuA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 GLU A 237
GLY A 235
TYR A 238
GLU A 292
 None
 1.33A 3w9tD-2pcuA:
undetectable		 3w9tD-2pcuA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 GLU A 237
GLY A 235
TYR A 238
GLU A 292
 None
 1.32A 3w9tG-2pcuA:
undetectable		 3w9tG-2pcuA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 LEU A 195
LEU A  64
MET A 301
THR A  82
 None
 1.30A 4do3A-2pcuA:
undetectable		 4do3A-2pcuA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 6 THR A 129
GLY A 115
PRO A 113
ASN A 112
 None
 0.84A 4fjpA-2pcuA:
undetectable		 4fjpA-2pcuA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 5 ILE A  18
ASN A   8
TYR A   9
ILE A  80
 None
 0.78A 4jtpA-2pcuA:
undetectable		 4jtpA-2pcuA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 12 ILE A 105
VAL A 180
THR A  78
LEU A 195
HIS A 196
 None
None
None
None
ZN  A 999 ( 3.1A)
 1.25A 5esgA-2pcuA:
undetectable		 5esgA-2pcuA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		5 / 12 LEU A 308
ALA A 266
PHE A 192
GLY A 191
PRO A  60
 None
 1.40A 5jglA-2pcuA:
undetectable		 5jglA-2pcuA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 6 ILE A  74
ILE A  86
LEU A 107
PHE A  29
 None
 0.97A 5vkqB-2pcuA:
undetectable
5vkqC-2pcuA:
undetectable		 5vkqB-2pcuA:
11.28
5vkqC-2pcuA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens) 		4 / 6 ILE A  74
ILE A  86
LEU A 107
PHE A  29
 None
 0.95A 5vkqC-2pcuA:
undetectable
5vkqD-2pcuA:
undetectable		 5vkqC-2pcuA:
11.28
5vkqD-2pcuA:
11.28