SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pd0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2pd0 HYPOTHETICAL PROTEIN
(Cryptosporidium
parvum) 		4 / 6 ARG A 142
ASN A  33
ASN A   6
LEU A  10
 None
None
MES  A 502 (-3.2A)
None
 1.25A 2nyrA-2pd0A:
undetectable		 2nyrA-2pd0A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2pd0 HYPOTHETICAL PROTEIN
(Cryptosporidium
parvum) 		5 / 12 ILE A  22
ALA A   9
LEU A  31
PHE A  30
ILE A  58
 None
 1.11A 4ej1B-2pd0A:
undetectable		 4ej1B-2pd0A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2pd0 HYPOTHETICAL PROTEIN
(Cryptosporidium
parvum) 		4 / 8 ASP A 137
CYH A 133
GLU A  89
GLU A 127
 None
None
None
MES  A 502 (-3.1A)
 1.07A 4gkhD-2pd0A:
undetectable		 4gkhD-2pd0A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2pd0 HYPOTHETICAL PROTEIN
(Cryptosporidium
parvum) 		5 / 12 ILE A  22
ALA A   9
LEU A  31
PHE A  30
ILE A  58
 None
 1.10A 4x5jA-2pd0A:
undetectable		 4x5jA-2pd0A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2pd0 HYPOTHETICAL PROTEIN
(Cryptosporidium
parvum) 		5 / 12 ILE A  22
ALA A   9
LEU A  31
PHE A  30
ILE A  58
 None
 1.33A 5z6fA-2pd0A:
undetectable		 5z6fA-2pd0A:
24.45