SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pd3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		4 / 5 ARG A 216
ALA A 257
LYS A 261
GLU A 260
 None
 1.14A 1e7cA-2pd3A:
undetectable		 1e7cA-2pd3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		4 / 6 GLU A 117
ALA A 161
LEU A 165
VAL A 157
 None
 1.14A 1sn5A-2pd3A:
undetectable		 1sn5A-2pd3A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		4 / 7 LEU A 221
VAL A 224
GLY A 225
VAL A  89
 None
 0.42A 1t88A-2pd3A:
undetectable		 1t88A-2pd3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		4 / 6 LEU A  85
PHE A  87
ALA A 138
LEU A 130
 None
 0.94A 1ukbA-2pd3A:
5.8		 1ukbA-2pd3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		4 / 8 LEU A 221
VAL A 224
GLY A 225
VAL A  89
 None
 0.20A 2a1oA-2pd3A:
undetectable		 2a1oA-2pd3A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		4 / 7 ILE A 191
ALA A 188
VAL A 246
GLY A 225
 NAD  A1780 (-4.4A)
NAD  A1780 (-4.5A)
None
None
 0.76A 2xrzB-2pd3A:
2.1		 2xrzB-2pd3A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		5 / 11 GLY A  23
ALA A  25
GLY A 228
LEU A 186
ILE A  11
 None
 0.94A 3em4A-2pd3A:
undetectable		 3em4A-2pd3A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		4 / 7 LEU A 232
LEU A 186
VAL A 219
SER A 220
 None
 1.01A 3r9vA-2pd3A:
undetectable
3r9vB-2pd3A:
undetectable		 3r9vA-2pd3A:
25.16
3r9vB-2pd3A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		5 / 12 GLY A 137
ALA A 138
ASP A  86
ILE A  88
THR A 127
 None
 0.90A 3s56A-2pd3A:
undetectable		 3s56A-2pd3A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		4 / 7 ALA A 188
GLY A 225
ILE A  24
THR A 193
 NAD  A1780 (-4.5A)
None
None
NAD  A1780 (-3.2A)
 0.87A 3spkB-2pd3A:
undetectable		 3spkB-2pd3A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		5 / 11 SER A  27
ILE A 191
VAL A  89
LEU A 141
PHE A  87
 None
NAD  A1780 (-4.4A)
None
None
None
 1.07A 3w67A-2pd3A:
2.4		 3w67A-2pd3A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		4 / 6 GLY A 228
LEU A 141
ASN A 184
GLU A 242
 None
 0.83A 3zqtA-2pd3A:
undetectable		 3zqtA-2pd3A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		4 / 8 LEU A  63
VAL A  65
LEU A  85
LEU A 130
 None
NAD  A1780 (-3.6A)
None
None
 1.00A 4l1xA-2pd3A:
undetectable		 4l1xA-2pd3A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		3 / 3 HIS A  90
VAL A  78
LEU A 130
 None
 0.75A 4m2vA-2pd3A:
undetectable		 4m2vA-2pd3A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		3 / 3 LEU A  10
PHE A  87
ILE A  11
 None
 0.72A 5dzk1-2pd3A:
undetectable
5dzkF-2pd3A:
undetectable
5dzkM-2pd3A:
undetectable		 5dzk1-2pd3A:
1.90
5dzkF-2pd3A:
22.06
5dzkM-2pd3A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		5 / 12 GLY A  13
SER A  91
HIS A  70
VAL A  78
LEU A 130
 NAD  A1780 (-3.7A)
NAD  A1780 ( 3.7A)
None
None
None
 1.19A 5ergB-2pd3A:
7.4		 5ergB-2pd3A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		4 / 7 VAL A  89
LEU A 221
GLY A  23
ALA A  25
 None
 0.90A 5f1aB-2pd3A:
undetectable		 5f1aB-2pd3A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		5 / 12 THR A 193
LEU A 126
ALA A  15
GLY A  13
SER A  91
 NAD  A1780 (-3.2A)
None
NAD  A1780 (-3.4A)
NAD  A1780 (-3.7A)
NAD  A1780 ( 3.7A)
 1.21A 5jglA-2pd3A:
6.8		 5jglA-2pd3A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		5 / 12 THR A 193
LEU A 126
ALA A  15
GLY A  13
SER A  91
 NAD  A1780 (-3.2A)
None
NAD  A1780 (-3.4A)
NAD  A1780 (-3.7A)
NAD  A1780 ( 3.7A)
 1.27A 5jglB-2pd3A:
5.2		 5jglB-2pd3A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		5 / 12 SER A 148
VAL A 224
VAL A 243
ALA A 185
LEU A 186
 None
 1.11A 5kocA-2pd3A:
4.4		 5kocA-2pd3A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		4 / 7 SER A 187
VAL A 219
PRO A 190
ILE A 205
 None
None
NAD  A1780 (-4.8A)
None
 1.21A 5vkqA-2pd3A:
undetectable
5vkqB-2pd3A:
undetectable		 5vkqA-2pd3A:
10.09
5vkqB-2pd3A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Helicobacter
pylori) 		4 / 7 SER A 187
VAL A 219
PRO A 190
ILE A 205
 None
None
NAD  A1780 (-4.8A)
None
 1.20A 5vkqC-2pd3A:
undetectable
5vkqD-2pd3A:
undetectable		 5vkqC-2pd3A:
10.09
5vkqD-2pd3A:
10.09